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1098-660X4862010JunJournal of clinical microbiologyJ Clin MicrobiolCagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.223722392237-910.1128/JCM.00662-10Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one CagA EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of the vacA i1 allele is a risk factor for increased activity (OR, 5.310; 95% CI, 2.295 to 12.287) and severity of gastritis (OR, 3.862; 95% CI, 1.728 to 8.632).PanayotopoulouEffrosini GEGLaboratory of Medical Microbiology, Hellenic Pasteur Institute, Athens, Greece.SgourasDionyssios NDNPapadakosKonstantinos SKSPetrakiKalliopiKBreurecSébastienSMichopoulosSpyrosSMantzarisGerassimosGPapatheodoridisGeorgeGMentisAndreasAArchimandritisAthanasiosAengGENBANKFN561978FN561979FN561980FN561981FN561982FN561983FN561984FN561985FN561986FN561987FN561988FN561989FN561990FN561991FN561992FN561993FN561994FN561995FN561996FN561997FN561998FN561999FN562000FN562001FN562002FN562003FN562004FN562005FN562006FN562007FN562008FN562009FN562010FN562011FN562012FN562013FN562014FN562015FN562016FN562017FN562018FN562019FN562020FN562021FN562022FN562023FN562024FN562025Journal ArticleResearch Support, Non-U.S. Gov't20100414
United StatesJ Clin Microbiol75055640095-11370Antigens, Bacterial0Bacterial Proteins0DNA, Bacterial0VacA protein, Helicobacter pylori0Virulence Factors0cagA protein, Helicobacter pyloriIMAdultAgedAntigens, BacterialgeneticsBacterial ProteinsgeneticsDNA, BacterialchemistrygeneticsFemaleHelicobacter InfectionsmicrobiologypathologyHelicobacter pylorigeneticsisolation & purificationpathogenicityHumansMaleMiddle AgedMolecular Sequence DataPeptic UlcermicrobiologyPolymorphism, GeneticSequence Analysis, DNASeverity of Illness IndexVirulence Factorsgenetics2010416602010416602010915602010121ppublish20392907PMC288451810.1128/JCM.00662-10JCM.00662-10Argent, R. H., M. Kidd, R. J. Owen, R. J. Thomas, M. C. Limb, and J. C. Atherton. 2004. Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori. Gastroenterology 127:514-523.15300584Atherton, J. C. 2006. The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases. Annu. Rev. 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Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA. Gastroenterology 130:1181-1190.16618412Nogueira, C., C. Figueiredo, F. Carneiro, A. T. Gomes, R. Barreira, P. Figueira, C. Salgado, L. Belo, A. Peixoto, J. C. Bravo, L. E. Bravo, J. L. Realpe, A. P. Plaisier, W. G. Quint, B. Ruiz, P. Correa, and L. J. van Doorn. 2001. Helicobacter pylori genotypes may determine gastric histopathology. Am. J. Pathol. 158:647-654.PMC185029911159201Nomura, A. M., G. I. Perez-Perez, J. Lee, G. Stemmermann, and M. J. Blaser. 2002. Relation between Helicobacter pylori cagA status and risk of peptic ulcer disease. Am. J. Epidemiol. 155:1054-1059.12034584Panayotopoulou, E. G., D. N. Sgouras, K. Papadakos, A. Kalliaropoulos, G. Papatheodoridis, A. F. Mentis, and A. J. Archimandritis. 2007. Strategy to characterize the number and type of repeating EPIYA phosphorylation motifs in the carboxyl terminus of CagA protein in Helicobacter pylori clinical isolates. J. Clin. Microbiol. 45:488-495.PMC182900817151214Rhead, J. L., D. P. Letley, M. Mohammadi, N. Hussein, M. A. Mohagheghi, M. Eshagh Hosseini, and J. C. Atherton. 2007. A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer. Gastroenterology 133:926-936.17854597Sgouras, D. N., E. G. Panayotopoulou, K. Papadakos, B. Martinez-Gonzalez, A. Roumbani, J. Panayiotou, C. vanVliet-Constantinidou, A. F. Mentis, and E. Roma-Giannikou. 2009. CagA and VacA polymorphisms do not correlate with severity of histopathological lesions in Helicobacter pylori-infected Greek children. J. Clin. Microbiol. 47:2426-2434.PMC272567619535517Soltermann, A., S. Koetzer, F. Eigenmann, and P. Komminoth. 2007. 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