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1096-9861519102011Jul01The Journal of comparative neurologyJ Comp NeurolFezf1 and Fezf2 are required for olfactory development and sensory neuron identity.182918461829-4610.1002/cne.22596The murine olfactory system consists of main and accessory systems that perform distinct and overlapping functions. The main olfactory epithelium (MOE) is primarily involved in the detection of volatile odorants, while neurons in the vomeronasal organ (VNO), part of the accessory olfactory system, are important for pheromone detection. During development, the MOE and VNO both originate from the olfactory pit; however, the mechanisms regulating development of these anatomically distinct organs from a common olfactory primordium are unknown. Here we report that two closely related zinc-finger transcription factors, FEZF1 and FEZF2, regulate the identity of MOE sensory neurons and are essential for the survival of VNO neurons respectively. Fezf1 is predominantly expressed in the MOE while Fezf2 expression is restricted to the VNO. In Fezf1-deficient mice, olfactory neurons fail to mature and also express markers of functional VNO neurons. In Fezf2-deficient mice, VNO neurons degenerate prior to birth. These results identify Fezf1 and Fezf2 as important regulators of olfactory system development and sensory neuron identity.Copyright © 2011 Wiley-Liss, Inc.EcklerMatthew JMJDepartment of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, California 95064, USA.McKennaWilliam LWLTaghvaeiSaharSMcConnellSusan KSKChenBinBengR01 EY008411EYNEI NIH HHSUnited States5-FY07-643PHS HHSUnited StatesEY08411EYNEI NIH HHSUnited StatesJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov't
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