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1573-49785082023AugMolecular biology reportsMol Biol RepThe role of GLUT2 in glucose metabolism in multiple organs and tissues.696369746963-697410.1007/s11033-023-08535-wThe glucose transporter family has an important role in the initial stage of glucose metabolism; Glucose transporters 2 (GLUTs, encoded by the solute carrier family 2, SLC2A genes) is the major glucose transporter in β-cells of pancreatic islets and hepatocytes but is also expressed in the small intestine, kidneys, and central nervous system; GLUT2 has a relatively low affinity to glucose. Under physiological conditions, GLUT2 transports glucose into cells and allows the glucose concentration to reach balance on the bilateral sides of the cellular membrane; Variation of GLUT2 is associated with various endocrine and metabolic disorders; In this study, we discussed the role of GLUT2 in participating in glucose metabolism and regulation in multiple organs and tissues and its effects on maintaining glucose homeostasis.© 2023. The Author(s).SunBoBEndorcrine and Metabolism Department, Lanzhou University Second Hospital, Lanzhou, 730000, China.Department of Infantile Endocrine Genetic Metabolism, Gansu Maternal and child Health Care Hospital, Lanzhou, 730000, China.ChenHuiH0000-0001-5717-1503Endorcrine and Metabolism Department, Lanzhou University Second Hospital, Lanzhou, 730000, China. chenhui@lzu.edu.com.XueJisuJEndEnorcrine and Metabolism Department, Shenzhen Bao 'an People's Hospital (Group), Shenzhen, 518100, China.LiPeiwuPKey Laboratory of Emergency Medicine, Lanzhou University Second Hospital, Lanzhou, 730000, China.FuXuXKey Laboratory of Emergency Medicine, Lanzhou University Second Hospital, Lanzhou, 730000, China.engJournal ArticleReview20230626
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