1532-85113412025JanJ Stroke Cerebrovasc DisAssociation between leisure-time physical activity and stroke in patients with chronic obstructive pulmonary disease: A population-based study.10816210816210.1016/j.jstrokecerebrovasdis.2024.108162S1052-3057(24)00605-0Stroke is the second leading cause of death worldwide. It remains unclear whether chronic obstructive pulmonary disease (COPD) increases the risk of stroke. The purpose of this study was to evaluate the association between COPD and stroke. As physical activity may prevent strokes, we examined whether leisure-time physical activity (LTPA) moderates stroke risk in COPD patients.13,524 participants from the 2009-2018 National Health and Nutrition Examination Survey (NHANES). We used the Global Physical Activity Questionnaire (GPAQ) questionnaire to obtain self-reported data from LTPA. We used a binary logistic regression model to analyze the association between LTPA, COPD, and stroke risk.The prevalence of COPD in the present study was 5.54%. The risk of stroke in COPD patients is 1.84 times higher than that in those without COPD, with a 95% confidence interval (95%CI) of 1.32,2.56 and P < 0.001. A lower stroke risk was observed in COPD patients who adhered to LTPA than those who did not (OR, 0.50; 95%CI, 0.26, 0.95; P = 0.03). As shown by the restricted cubic spline (RCS), the duration of LTPA in COPD patients was inversely related to the risk of stroke, which decreased as the duration of weekly LTPA increased.COPD is positively associated with stroke risk. LTPA reduces the risk of stroke in patients with COPD, suggesting that it may be a promising measure for preventing stroke in this population.Copyright © 2024 The Author(s). Published by Elsevier Inc. All rights reserved.WangHongpingHDepartment of Neurosurgery, Zigong Fourth People's Hospital, 19 Tanmulin Street, Zigong, Sichuan 643000, China. Electronic address: whp1071@163.com.TianMaoliangMDepartment of Pulmonary and Critical Care Medicine, Zigong First People's Hospital, 42 Shangyihao Yizhi Street, Zigong, Sichuan 643000, China. Electronic address: tml666tml123@163.com.LaiQunQDepartment of Hematology and Rheumatology, Zigong Fourth People's Hospital, 19 Tanmulin Street, Zigong, Sichuan 643000, China. Electronic address: laiqun1071@163.com.LiWenqiangWDepartment of Pulmonary and Critical Care Medicine, Zigong First People's Hospital, 42 Shangyihao Yizhi Street, Zigong, Sichuan 643000, China. Electronic address: lwq1858320@163.com.DingHaoHDepartment of Neurosurgery, Zigong Fourth People's Hospital, 19 Tanmulin Street, Zigong, Sichuan 643000, China. Electronic address: dinghaowws@126.com.DengZhipingZDepartment of Pulmonary and Critical Care Medicine, Zigong First People's Hospital, 42 Shangyihao Yizhi Street, Zigong, Sichuan 643000, China. Electronic address: dengzp1016@163.com.engJournal Article20241127