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1872-9452342-32013Apr-JunMolecular aspects of medicineMol Aspects MedThe SLC2 (GLUT) family of membrane transporters.121138121-3810.1016/j.mam.2012.07.001S0098-2997(12)00084-2GLUT proteins are encoded by the SLC2 genes and are members of the major facilitator superfamily of membrane transporters. Fourteen GLUT proteins are expressed in the human and they are categorized into three classes based on sequence similarity. All GLUTs appear to transport hexoses or polyols when expressed ectopically, but the primary physiological substrates for several of the GLUTs remain uncertain. GLUTs 1-5 are the most thoroughly studied and all have well established roles as glucose and/or fructose transporters in various tissues and cell types. The GLUT proteins are comprised of ∼500 amino acid residues, possess a single N-linked oligosaccharide, and have 12 membrane-spanning domains. In this review we briefly describe the major characteristics of the 14 GLUT family members.Copyright © 2012 Elsevier Ltd. All rights reserved.MuecklerMikeMDepartment of Cell Biology, Washington University School of Medicine, St. Louis, MO 63110, USA. mmueckler@wustl.eduThorensBernardBengP30 DK020579DKNIDDK NIH HHSUnited StatesR01 DK043695DKNIDDK NIH HHSUnited StatesR01 DK085110DKNIDDK NIH HHSUnited StatesR0143695PHS HHSUnited StatesJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov'tReview
EnglandMol Aspects Med76031280098-29970Glucose Transport Proteins, Facilitative0Hexoses0Polymers0polyolIMAmino Acid SequenceBiological TransportphysiologyGlucose Transport Proteins, FacilitativeclassificationgeneticsmetabolismphysiologyHexosesmetabolismHumansModels, BiologicalModels, MolecularMolecular Sequence DataMolecular StructureMultigene FamilygeneticsPolymersmetabolismProtein ConformationProtein Structure, Tertiary2012362012732013320602013320602013910602014721ppublish23506862NIHMS394095PMC410497810.1016/j.mam.2012.07.001S0098-2997(12)00084-2Abel ED, Peroni O, Kim JK, Kim YB, Boss O, Hadro E, Minnemann T, Shulman GI, Kahn BB. Adipose-selective targeting of the GLUT4 gene impairs insulin action in muscle and liver. [see comments] Nature. 2001;409(6821):729–733.11217863Abramson J, Smirnova I, Kasho V, Verner G, Kaback HR, Iwata S. 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