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<PubmedArticle><MedlineCitation Status="MEDLINE" Owner="NLM" IndexingMethod="Automated"><PMID Version="1">40411614</PMID><DateCompleted><Year>2025</Year><Month>05</Month><Day>24</Day></DateCompleted><DateRevised><Year>2025</Year><Month>12</Month><Day>31</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1434-3916</ISSN><JournalIssue CitedMedium="Internet"><Volume>145</Volume><Issue>1</Issue><PubDate><Year>2025</Year><Month>May</Month><Day>24</Day></PubDate></JournalIssue><Title>Archives of orthopaedic and trauma surgery</Title><ISOAbbreviation>Arch Orthop Trauma Surg</ISOAbbreviation></Journal><ArticleTitle>No difference in reoperation rates or aseptic loosening following cemented total knee arthroplasty with or without a tourniquet.</ArticleTitle><Pagination><StartPage>313</StartPage><MedlinePgn>313</MedlinePgn></Pagination><ELocationID EIdType="doi" ValidYN="Y">10.1007/s00402-025-05933-6</ELocationID><Abstract><AbstractText Label="INTRODUCTION" NlmCategory="BACKGROUND">The objective of the current study was to evaluate the reoperation rate among patients undergoing cemented total knee arthroplasty (TKA) with or without an intraoperative tourniquet.</AbstractText><AbstractText Label="MATERIALS AND METHODS" NlmCategory="METHODS">A retrospective cohort study of consecutive patients who received a primary, cemented TKA at a high volume academic orthopaedic center. Eligible patients underwent primary, cemented TKA either with or without the use of a tourniquet throughout the entirety of the care. The causes and timing of reoperations were recorded. Survivorship analysis was conducted using Kaplan-Meier curves. Cox proportional hazards models were utilized to evaluate independent predictors of reoperation.</AbstractText><AbstractText Label="RESULTS" NlmCategory="RESULTS">There were 2276 (58%) cases in which a tourniquet was used and 1663 (42%) cases with no tourniquet use. Mean time from the primary TKA was 14.7 years. The cumulative survival at final follow-up for the no tourniquet group and tourniquet group were 92.2% and 96.5%, respectively. Only younger age was an independent predictor of both all cause revision and aseptic loosening.</AbstractText><AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Adjusting for confounders, the presence of a tourniquet did not affect the rates of long-term all-cause revision rates or aseptic loosening. Younger patients have a higher risk of all-cause reoperation and reoperation due to aseptic loosening.</AbstractText><AbstractText Label="LEVEL OF EVIDENCE" NlmCategory="METHODS">Level III.</AbstractText><CopyrightInformation>&#xa9; 2025. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Gazendam</LastName><ForeName>Aaron</ForeName><Initials>A</Initials><AffiliationInfo><Affiliation>McMaster University Division of Orthopaedics, Hamilton, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hamilton Arthroplasty Group, Hamilton Health Sciences, Hamilton, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Abdel Khalik</LastName><ForeName>Hassaan</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>McMaster University Division of Orthopaedics, Hamilton, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Patel</LastName><ForeName>Mansi</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>McMaster University, Hamilton, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Ekhtiari</LastName><ForeName>Seper</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>McMaster University Division of Orthopaedics, Hamilton, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hamilton Arthroplasty Group, Hamilton Health Sciences, Hamilton, Canada.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Tate</LastName><ForeName>Isabelle</ForeName><Initials>I</Initials><AffiliationInfo><Affiliation>Hamilton Arthroplasty Group, Hamilton Health Sciences, Hamilton, Canada. tate@hhsc.ca.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wood</LastName><ForeName>Thomas J</ForeName><Initials>TJ</Initials><AffiliationInfo><Affiliation>McMaster University Division of Orthopaedics, Hamilton, Canada.</Affiliation></AffiliationInfo><AffiliationInfo><Affiliation>Hamilton Arthroplasty Group, Hamilton Health Sciences, Hamilton, Canada.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2025</Year><Month>05</Month><Day>24</Day></ArticleDate></Article><MedlineJournalInfo><Country>Germany</Country><MedlineTA>Arch Orthop Trauma Surg</MedlineTA><NlmUniqueID>9011043</NlmUniqueID><ISSNLinking>0936-8051</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D001843">Bone Cements</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D019645" MajorTopicYN="Y">Arthroplasty, Replacement, Knee</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D012086" MajorTopicYN="N">Reoperation</DescriptorName><QualifierName UI="Q000706" MajorTopicYN="N">statistics &amp; numerical data</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014111" MajorTopicYN="Y">Tourniquets</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D012189" MajorTopicYN="N">Retrospective Studies</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008297" MajorTopicYN="N">Male</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000368" MajorTopicYN="N">Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005260" MajorTopicYN="N">Female</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011475" MajorTopicYN="Y">Prosthesis Failure</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D008875" MajorTopicYN="N">Middle Aged</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000369" MajorTopicYN="N">Aged, 80 and over</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D001843" MajorTopicYN="N">Bone Cements</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Cemented</Keyword><Keyword MajorTopicYN="N">Reoperation</Keyword><Keyword MajorTopicYN="N">Revision</Keyword><Keyword MajorTopicYN="N">Total knee arthroplasty</Keyword><Keyword MajorTopicYN="N">Tourniquet</Keyword></KeywordList><CoiStatement>Declarations. 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