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0012-160618421997Apr15Developmental biologyDev BiolXnr4: a Xenopus nodal-related gene expressed in the Spemann organizer.367372367-72We have isolated a novel TGF beta-like gene from Xenopus which is highly related to mouse nodal The gene, Xnr4, is expressed at the gastrula stage in the Spemann organizer and at later stages in the notochord and neural tube. Ectopic expression of Xnr4 can induce and dorsalize mesoderm. These studies suggest that Xnr4, along with other nodal-related genes (Xnr1-3), may participate in mesodermal patterning and possibly neural development.JosephE MEMDepartment of Molecular and Cellular Biology, Harvard University, Cambridge, Massachusetts 02138, USA.MeltonD ADAengGENBANKU79162Journal ArticleResearch Support, Non-U.S. Gov'tResearch Support, U.S. Gov't, P.H.S.
United StatesDev Biol03727620012-16060DNA Primers0DNA, Antisense0Intercellular Signaling Peptides and Proteins0NODAL protein, Xenopus0Nodal Protein0Nodal protein, mouse0Proteins0RNA, Messenger0Transforming Growth Factor beta0Xenopus Proteins0cer1 protein, XenopusIMAmino Acid SequenceAnimalsCloning, MolecularDNA PrimersDNA, AntisensegeneticsmetabolismEmbryo, NonmammalianmetabolismEmbryonic InductionGastrulametabolismIn Situ HybridizationIntercellular Signaling Peptides and ProteinsMesodermcytologyMicroinjectionsMolecular Sequence DataNodal ProteinOocytesProteinschemistrygeneticsmetabolismRNA, MessengermetabolismSequence Homology, Amino AcidTransforming Growth Factor betaXenopusembryologyXenopus Proteins1997415199741501199741500ppublish913344210.1006/dbio.1997.8510S0012-1606(97)98510-9