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1546-172613112010NovNature neuroscienceNat NeurosciFezf2 directs the differentiation of corticofugal neurons from striatal progenitors in vivo.134513471345-710.1038/nn.2658In the developing cerebral cortex, cell-extrinsic and cell-intrinsic signals govern the establishment of neuron subtype-specific identity. Here we show that, within the niche of the striatum, the expression of a single transcription factor, Fezf2, is sufficient to generate corticofugal neurons from progenitors fated to become medium spiny neurons. This demonstrates that a specific population of cortical projection neurons can be directed to differentiate outside of the cortex by cell-autonomous signaling.RouauxCarolineCCenter for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA.ArlottaPaolaPengR01 NS062849NSNINDS NIH HHSUnited StatesNS062849NSNINDS NIH HHSUnited StatesJournal ArticleResearch Support, N.I.H., ExtramuralResearch Support, Non-U.S. Gov't20101017
United StatesNat Neurosci98096711097-62560DNA-Binding Proteins0Nerve Tissue Proteins0Transcription Factors0Zfp312 protein, mouse147336-22-9Green Fluorescent ProteinsIMNat Neurosci. 2010 Nov;13(11):1308-9. doi: 10.1038/nn1110-1308.20975751AnimalsCell DifferentiationgeneticsphysiologyCerebral CortexcytologyCorpus StriatumcytologyDNA-Binding ProteinsgeneticsmetabolismEmbryo, MammalianEmbryonic Stem CellsphysiologyGene Expression Regulation, DevelopmentalgeneticsphysiologyGreen Fluorescent ProteinsgeneticsMiceMice, TransgenicNerve Tissue ProteinsgeneticsmetabolismNeuronsclassificationphysiologyTranscription FactorsgeneticsmetabolismCOMPETING FINANCIAL INTERESTS. The authors declare no competing financial interests.201079201082320101019602010101960201011136020141023ppublish20953195NIHMS634541PMC420744210.1038/nn.2658nn.2658Molyneaux BJ, Arlotta P, Menezes JR, Macklis JD. Nat Rev Neurosci. 2007;8:427–437.17514196Rallu M, Corbin JG, Fishell G. Nat Rev Neurosci. 2002;3:943–951.12461551Schuurmans C, Guillemot F. Curr Opin Neurobiol. 2002;12:26–34.11861161Schuurmans C, et al. EMBO J. 2004;23:2892–2902.PMC51494215229646Arlotta P, et al. Neuron. 2005;45:207–221.15664173Molyneaux BJ, et al. J Neurosci. 2009;29:12343–12354.PMC277607519793993Chen B, Schaevitz LR, McConnell SK. Proc Natl Acad Sci USA. 2005;102:17184–17189.PMC128256916284245Chen JG, Rasin MR, Kwan KY, Sestan N. Proc Natl Acad Sci USA. 2005;102:17792–17797.PMC130892816314561Molyneaux BJ, Arlotta P, Hirata T, Hibi M, Macklis JD. Neuron. 2005;47:817–831.16157277Wichterle H, Turnbull DH, Nery S, Fishell G, Alvarez-Buylla A. Development. 2001;128:3759–3771.11585802Mattar P, et al. Mol Cell Biol. 2008;28:1456–1469.PMC225879018160702Campbell K, Olsson M, Bjorklund A. Neuron. 1995;15:1259–1273.8845151Fishell G. Development. 1995;121:803–812.7720584Magrassi L, et al. Development. 1998;125:2847–2855.9655807