0959-437X1242002AugCurr Opin Genet DevThe Otx family.409415409-15Otx1 and Otx2, the murine homologs of the Drosophila orthodenticle gene, play a remarkable role in specification and regionalization of forebrain and midbrain. Recently, genetic approaches have indicated that OTD, OTX1 and OTX2 have retained reciprocal functional equivalence in evolution, whereas their regulatory control has been remarkably modified. This suggests that during the evolution of the vertebrate brain, regulatory changes modulating the transcriptional and translational control of pre-existing gene functions might have favored the establishment of new morphogenetic pathways.SimeoneAntonioAMRC Centre for Developmental Neurobiology, New Hunt's House, 4th Floor, King's College London, Guy's campus, London Bridge, UK. antonio.simeone@kcl.ac.ukPuellesEduardoEAcamporaDarioDengJournal ArticleResearch Support, Non-U.S. Gov'tReview