{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"10436162"},"DateCompleted":{"Year":"1999","Month":"08","Day":"19"},"DateRevised":{"Year":"2019","Month":"06","Day":"19"},"Article":{"@attributes":{"PubModel":"Print"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Print"},"@text":"0036-8075"},"JournalIssue":{"@attributes":{"CitedMedium":"Print"},"Volume":"285","Issue":"5429","PubDate":{"Year":"1999","Month":"Aug","Day":"06"}},"Title":"Science (New York, N.Y.)","ISOAbbreviation":"Science"},"ArticleTitle":"Early neocortical regionalization in the absence of thalamic innervation.","Pagination":{"StartPage":"906","EndPage":"909","MedlinePgn":"906-9"},"Abstract":{"AbstractText":["There is a long-standing controversy regarding the mechanisms that generate the functional subdivisions of the cerebral neocortex. One model proposes that thalamic axonal input specifies these subdivisions; the competing model postulates that patterning mechanisms intrinsic to the dorsal telencephalon generate neocortical regions. Gbx-2 mutant mice, whose thalamic differentiation is disrupted, were investigated. Despite the lack of cortical innervation by thalamic axons, neocortical region-specific gene expression (Cadherin-6, EphA-7, Id-2, and RZR-beta) developed normally. This provides evidence that patterning mechanisms intrinsic to the neocortex specify the basic organization of its functional subdivisions."]},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Miyashita-Lin","ForeName":"E M","Initials":"EM","AffiliationInfo":[{"Affiliation":"Nina Ireland Laboratory of Developmental Neurobiology, Department of Psychiatry, School of Medicine, University of California San Francisco, San Francisco, CA 94143-0984, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Hevner","ForeName":"R","Initials":"R"},{"@attributes":{"ValidYN":"Y"},"LastName":"Wassarman","ForeName":"K M","Initials":"KM"},{"@attributes":{"ValidYN":"Y"},"LastName":"Martinez","ForeName":"S","Initials":"S"},{"@attributes":{"ValidYN":"Y"},"LastName":"Rubenstein","ForeName":"J L","Initials":"JL"}]},"Language":["eng"],"GrantList":{"@attributes":{"CompleteYN":"N"},"Grant":[{"GrantID":"NS34661-01A1","Acronym":"NS","Agency":"NINDS NIH HHS","Country":"United States"},{"GrantID":"R01 MH49428-01","Acronym":"MH","Agency":"NIMH NIH HHS","Country":"United States"},{"GrantID":"R01 MH51561-01A1","Acronym":"MH","Agency":"NIMH NIH HHS","Country":"United States"}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D013485"},"@text":"Research Support, Non-U.S. Gov't"},{"@attributes":{"UI":"D013487"},"@text":"Research Support, U.S. Gov't, P.H.S."}]}},"MedlineJournalInfo":{"Country":"United States","MedlineTA":"Science","NlmUniqueID":"0404511","ISSNLinking":"0036-8075"},"ChemicalList":{"Chemical":[{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D015820"},"@text":"Cadherins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D064032"},"@text":"Calbindin 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Surface"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D018160"},"@text":"Receptors, Cytoplasmic and Nuclear"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D044094"},"@text":"Receptors, Melatonin"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D064030"},"@text":"S100 Calcium Binding Protein G"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D014157"},"@text":"Transcription Factors"}},{"RegistryNumber":"40957-95-7","NameOfSubstance":{"@attributes":{"UI":"C024286"},"@text":"3,3'-dioctadecylindocarbocyanine"}},{"RegistryNumber":"EC 1.14.14.19","NameOfSubstance":{"@attributes":{"UI":"D013254"},"@text":"Steroid 17-alpha-Hydroxylase"}},{"RegistryNumber":"U9G6UFV40X","NameOfSubstance":{"@attributes":{"UI":"C087310"},"@text":"K cadherin"}}]},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D001369","MajorTopicYN":"N"},"@text":"Axons"},"QualifierName":[{"@attributes":{"UI":"Q000737","MajorTopicYN":"N"},"@text":"chemistry"},{"@attributes":{"UI":"Q000502","MajorTopicYN":"Y"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D015820","MajorTopicYN":"N"},"@text":"Cadherins"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D064032","MajorTopicYN":"N"},"@text":"Calbindin 2"}},{"DescriptorName":{"@attributes":{"UI":"D002232","MajorTopicYN":"N"},"@text":"Carbocyanines"}},{"DescriptorName":{"@attributes":{"UI":"D004268","MajorTopicYN":"N"},"@text":"DNA-Binding 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