{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"10896157"},"DateCompleted":{"Year":"2000","Month":"08","Day":"07"},"DateRevised":{"Year":"2021","Month":"01","Day":"08"},"Article":{"@attributes":{"PubModel":"Print"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Print"},"@text":"0896-6273"},"JournalIssue":{"@attributes":{"CitedMedium":"Print"},"Volume":"26","Issue":"3","PubDate":{"Year":"2000","Month":"Jun"}},"Title":"Neuron","ISOAbbreviation":"Neuron"},"ArticleTitle":"GRASP-1: a neuronal RasGEF associated with the AMPA receptor\/GRIP complex.","Pagination":{"StartPage":"603","EndPage":"617","MedlinePgn":"603-17"},"Abstract":{"AbstractText":["The PDZ domain-containing proteins, such as PSD-95 and GRIP, have been suggested to be involved in the targeting of glutamate receptors, a process that plays a critical role in the efficiency of synaptic transmission and plasticity. To address the molecular mechanisms underlying AMPA receptor synaptic localization, we have identified several GRIP-associated proteins (GRASPs) that bind to distinct PDZ domains within GRIP. GRASP-1 is a neuronal rasGEF associated with GRIP and AMPA receptors in vivo. Overexpression of GRASP-1 in cultured neurons specifically reduced the synaptic targeting of AMPA receptors. In addition, the subcellular distribution of both AMPA receptors and GRASP-1 was rapidly regulated by the activation of NMDA receptors. These results suggest that GRASP-1 may regulate neuronal ras signaling and contribute to the regulation of AMPA receptor distribution by NMDA receptor activity."]},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Ye","ForeName":"B","Initials":"B","AffiliationInfo":[{"Affiliation":"Howard Hughes Medical Institute, Department of Neuroscience, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Liao","ForeName":"D","Initials":"D"},{"@attributes":{"ValidYN":"Y"},"LastName":"Zhang","ForeName":"X","Initials":"X"},{"@attributes":{"ValidYN":"Y"},"LastName":"Zhang","ForeName":"P","Initials":"P"},{"@attributes":{"ValidYN":"Y"},"LastName":"Dong","ForeName":"H","Initials":"H"},{"@attributes":{"ValidYN":"Y"},"LastName":"Huganir","ForeName":"R L","Initials":"RL"}]},"Language":["eng"],"DataBankList":{"@attributes":{"CompleteYN":"Y"},"DataBank":[{"DataBankName":"GENBANK","AccessionNumberList":{"AccessionNumber":["AF040944","AF274057"]}}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D013485"},"@text":"Research Support, Non-U.S. Gov't"},{"@attributes":{"UI":"D013487"},"@text":"Research Support, U.S. Gov't, P.H.S."}]}},"MedlineJournalInfo":{"Country":"United States","MedlineTA":"Neuron","NlmUniqueID":"8809320","ISSNLinking":"0896-6273"},"ChemicalList":{"Chemical":[{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D002352"},"@text":"Carrier Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C485827"},"@text":"GRIPAP1 protein, human"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C491308"},"@text":"Grip1 protein, rat"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D047908"},"@text":"Intracellular Signaling Peptides and Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D008565"},"@text":"Membrane Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D009419"},"@text":"Nerve Tissue Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D020033"},"@text":"Protein Isoforms"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D018091"},"@text":"Receptors, AMPA"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D016194"},"@text":"Receptors, N-Methyl-D-Aspartate"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D020663"},"@text":"ras Guanine Nucleotide Exchange Factors"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C410230"},"@text":"tamalin protein, human"}},{"RegistryNumber":"EC 3.4.22.-","NameOfSubstance":{"@attributes":{"UI":"C505407"},"@text":"CASP3 protein, human"}},{"RegistryNumber":"EC 3.4.22.-","NameOfSubstance":{"@attributes":{"UI":"C505410"},"@text":"Casp3 protein, rat"}},{"RegistryNumber":"EC 3.4.22.-","NameOfSubstance":{"@attributes":{"UI":"D053148"},"@text":"Caspase 3"}},{"RegistryNumber":"EC 3.4.22.-","NameOfSubstance":{"@attributes":{"UI":"D020169"},"@text":"Caspases"}}]},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D000595","MajorTopicYN":"N"},"@text":"Amino Acid Sequence"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D002352","MajorTopicYN":"N"},"@text":"Carrier Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000302","MajorTopicYN":"N"},"@text":"isolation & 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Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D009474","MajorTopicYN":"N"},"@text":"Neurons"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D020033","MajorTopicYN":"N"},"@text":"Protein Isoforms"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D051381","MajorTopicYN":"N"},"@text":"Rats"}},{"DescriptorName":{"@attributes":{"UI":"D017207","MajorTopicYN":"N"},"@text":"Rats, Sprague-Dawley"}},{"DescriptorName":{"@attributes":{"UI":"D018091","MajorTopicYN":"N"},"@text":"Receptors, AMPA"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D016194","MajorTopicYN":"N"},"@text":"Receptors, N-Methyl-D-Aspartate"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"N"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D013379","MajorTopicYN":"N"},"@text":"Substrate Specificity"}},{"DescriptorName":{"@attributes":{"UI":"D013569","MajorTopicYN":"N"},"@text":"Synapses"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D014018","MajorTopicYN":"N"},"@text":"Tissue Distribution"}},{"DescriptorName":{"@attributes":{"UI":"D020663","MajorTopicYN":"N"},"@text":"ras Guanine Nucleotide Exchange Factors"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]}]}},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"pubmed"},"Year":"2000","Month":"7","Day":"15","Hour":"11","Minute":"0"},{"@attributes":{"PubStatus":"medline"},"Year":"2000","Month":"8","Day":"12","Hour":"11","Minute":"0"},{"@attributes":{"PubStatus":"entrez"},"Year":"2000","Month":"7","Day":"15","Hour":"11","Minute":"0"}]},"PublicationStatus":"ppublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"10896157"},{"@attributes":{"IdType":"doi"},"@text":"10.1016\/s0896-6273(00)81198-8"},{"@attributes":{"IdType":"pii"},"@text":"S0896-6273(00)81198-8"}]}}}}