{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"11931740"},"DateCompleted":{"Year":"2002","Month":"04","Day":"29"},"DateRevised":{"Year":"2019","Month":"12","Day":"10"},"Article":{"@attributes":{"PubModel":"Print"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Print"},"@text":"0896-6273"},"JournalIssue":{"@attributes":{"CitedMedium":"Print"},"Volume":"34","Issue":"1","PubDate":{"Year":"2002","Month":"Mar","Day":"28"}},"Title":"Neuron","ISOAbbreviation":"Neuron"},"ArticleTitle":"Interaction between GRIP and liprin-alpha\/SYD2 is required for AMPA receptor targeting.","Pagination":{"StartPage":"39","EndPage":"52","MedlinePgn":"39-52"},"Abstract":{"AbstractText":["Interaction with the multi-PDZ protein GRIP is required for the synaptic targeting of AMPA receptors, but the underlying mechanism is unknown. We show that GRIP binds to the liprin-alpha\/SYD2 family of proteins that interact with LAR receptor protein tyrosine phosphatases (LAR-RPTPs) and that are implicated in presynaptic development. In neurons, liprin-alpha and LAR-RPTP are enriched at synapses and coimmunoprecipitate with GRIP and AMPA receptors. Dominant-negative constructs that interfere with the GRIP-liprin interaction disrupt the surface expression and dendritic clustering of AMPA receptors in cultured neurons. Thus, by mediating the targeting of liprin\/GRIP-associated proteins, liprin-alpha is important for postsynaptic as well as presynaptic maturation."]},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Wyszynski","ForeName":"Michael","Initials":"M","AffiliationInfo":[{"Affiliation":"Department of Neurobiology and Howard Hughes Medical Institute, Massachusetts General Hospital and Harvard Medical School, Boston, MA 02114, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Kim","ForeName":"Eunjoon","Initials":"E"},{"@attributes":{"ValidYN":"Y"},"LastName":"Dunah","ForeName":"Anthone W","Initials":"AW"},{"@attributes":{"ValidYN":"Y"},"LastName":"Passafaro","ForeName":"Maria","Initials":"M"},{"@attributes":{"ValidYN":"Y"},"LastName":"Valtschanoff","ForeName":"Juli G","Initials":"JG"},{"@attributes":{"ValidYN":"Y"},"LastName":"Serra-Pag\u00e8s","ForeName":"Carles","Initials":"C"},{"@attributes":{"ValidYN":"Y"},"LastName":"Streuli","ForeName":"Michel","Initials":"M"},{"@attributes":{"ValidYN":"Y"},"LastName":"Weinberg","ForeName":"Richard J","Initials":"RJ"},{"@attributes":{"ValidYN":"Y"},"LastName":"Sheng","ForeName":"Morgan","Initials":"M"}]},"Language":["eng"],"GrantList":{"@attributes":{"CompleteYN":"Y"},"Grant":[{"GrantID":"CA 55547","Acronym":"CA","Agency":"NCI NIH HHS","Country":"United States"},{"GrantID":"NS35050","Acronym":"NS","Agency":"NINDS NIH HHS","Country":"United States"}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D013485"},"@text":"Research Support, Non-U.S. Gov't"},{"@attributes":{"UI":"D013487"},"@text":"Research Support, U.S. Gov't, P.H.S."}]}},"MedlineJournalInfo":{"Country":"United States","MedlineTA":"Neuron","NlmUniqueID":"8809320","ISSNLinking":"0896-6273"},"ChemicalList":{"Chemical":[{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D048868"},"@text":"Adaptor Proteins, Signal Transducing"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D002352"},"@text":"Carrier Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C491310"},"@text":"GRIP1 protein, human"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C491308"},"@text":"Grip1 protein, rat"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D047908"},"@text":"Intracellular Signaling Peptides and Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D009419"},"@text":"Nerve Tissue Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D010750"},"@text":"Phosphoproteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C490599"},"@text":"Ppfia4 protein, rat"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D018091"},"@text":"Receptors, AMPA"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D011956"},"@text":"Receptors, Cell Surface"}},{"RegistryNumber":"EC 3.1.3.48","NameOfSubstance":{"@attributes":{"UI":"C516772"},"@text":"PTPRF protein, human"}},{"RegistryNumber":"EC 3.1.3.48","NameOfSubstance":{"@attributes":{"UI":"D017027"},"@text":"Protein Tyrosine Phosphatases"}},{"RegistryNumber":"EC 3.1.3.48","NameOfSubstance":{"@attributes":{"UI":"C516774"},"@text":"Ptprf protein, rat"}},{"RegistryNumber":"EC 3.1.3.48","NameOfSubstance":{"@attributes":{"UI":"D054623"},"@text":"Receptor-Like Protein Tyrosine Phosphatases, Class 2"}}]},"CitationSubset":["IM"],"CommentsCorrectionsList":{"CommentsCorrections":[{"@attributes":{"RefType":"CommentIn"},"RefSource":"Neuron. 2002 Mar 28;34(1):1-2. doi: 10.1016\/s0896-6273(02)00649-9.","PMID":{"@attributes":{"Version":"1"},"@text":"11931733"}}]},"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D048868","MajorTopicYN":"N"},"@text":"Adaptor Proteins, Signal Transducing"}},{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D001921","MajorTopicYN":"N"},"@text":"Brain"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"N"},"@text":"cytology"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D019556","MajorTopicYN":"N"},"@text":"COS Cells"}},{"DescriptorName":{"@attributes":{"UI":"D002352","MajorTopicYN":"N"},"@text":"Carrier Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D002478","MajorTopicYN":"N"},"@text":"Cells, Cultured"}},{"DescriptorName":{"@attributes":{"UI":"D004622","MajorTopicYN":"N"},"@text":"Embryo, Mammalian"}},{"DescriptorName":{"@attributes":{"UI":"D047908","MajorTopicYN":"N"},"@text":"Intracellular Signaling Peptides and Proteins"}},{"DescriptorName":{"@attributes":{"UI":"D009419","MajorTopicYN":"N"},"@text":"Nerve Tissue Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D009474","MajorTopicYN":"N"},"@text":"Neurons"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"},{"@attributes":{"UI":"Q000648","MajorTopicYN":"N"},"@text":"ultrastructure"}]},{"DescriptorName":{"@attributes":{"UI":"D010750","MajorTopicYN":"N"},"@text":"Phosphoproteins"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D017027","MajorTopicYN":"Y"},"@text":"Protein Tyrosine Phosphatases"}},{"DescriptorName":{"@attributes":{"UI":"D051381","MajorTopicYN":"N"},"@text":"Rats"}},{"DescriptorName":{"@attributes":{"UI":"D054623","MajorTopicYN":"N"},"@text":"Receptor-Like Protein Tyrosine Phosphatases, Class 2"}},{"DescriptorName":{"@attributes":{"UI":"D018091","MajorTopicYN":"N"},"@text":"Receptors, AMPA"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D011956","MajorTopicYN":"N"},"@text":"Receptors, Cell Surface"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D013569","MajorTopicYN":"N"},"@text":"Synapses"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"},{"@attributes":{"UI":"Q000648","MajorTopicYN":"N"},"@text":"ultrastructure"}]}]}},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"pubmed"},"Year":"2002","Month":"4","Day":"5","Hour":"10","Minute":"0"},{"@attributes":{"PubStatus":"medline"},"Year":"2002","Month":"5","Day":"1","Hour":"10","Minute":"1"},{"@attributes":{"PubStatus":"entrez"},"Year":"2002","Month":"4","Day":"5","Hour":"10","Minute":"0"}]},"PublicationStatus":"ppublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"11931740"},{"@attributes":{"IdType":"doi"},"@text":"10.1016\/s0896-6273(02)00640-2"},{"@attributes":{"IdType":"pii"},"@text":"S0896627302006402"}]}}}}