{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"11972042"},"DateCompleted":{"Year":"2002","Month":"06","Day":"11"},"DateRevised":{"Year":"2022","Month":"03","Day":"09"},"Article":{"@attributes":{"PubModel":"Print-Electronic"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Print"},"@text":"0027-8424"},"JournalIssue":{"@attributes":{"CitedMedium":"Print"},"Volume":"99","Issue":"9","PubDate":{"Year":"2002","Month":"Apr","Day":"30"}},"Title":"Proceedings of the National Academy of Sciences of the United States of America","ISOAbbreviation":"Proc Natl Acad Sci U S A"},"ArticleTitle":"Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa.","Pagination":{"StartPage":"6328","EndPage":"6333","MedlinePgn":"6328-33"},"Abstract":{"AbstractText":["Rhodopsin is the G protein-coupled receptor that is activated by light and initiates the transduction cascade leading to night (rod) vision. Naturally occurring pathogenic rhodopsin (RHO) mutations have been previously identified only in humans and are a common cause of dominantly inherited blindness from retinal degeneration. We identified English Mastiff dogs with a naturally occurring dominant retinal degeneration and determined the cause to be a point mutation in the RHO gene (Thr4Arg). Dogs with this mutant allele manifest a retinal phenotype that closely mimics that in humans with RHO mutations. The phenotypic features shared by dog and man include a dramatically slowed time course of recovery of rod photoreceptor function after light exposure and a distinctive topographic pattern to the retinal degeneration. The canine disease offers opportunities to explore the basis of prolonged photoreceptor recovery after light in RHO mutations and determine whether there are links between the dysfunction and apoptotic retinal cell death. The RHO mutant dog also becomes the large animal needed for preclinical trials of therapies for a major subset of human retinopathies."]},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Kijas","ForeName":"James W","Initials":"JW","AffiliationInfo":[{"Affiliation":"James A. Baker Institute for Animal Health, Cornell University, 47 Hungerford Hill Road, Ithaca, NY 14853, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Cideciyan","ForeName":"Artur V","Initials":"AV"},{"@attributes":{"ValidYN":"Y"},"LastName":"Aleman","ForeName":"Tomas S","Initials":"TS"},{"@attributes":{"ValidYN":"Y"},"LastName":"Pianta","ForeName":"Michael J","Initials":"MJ"},{"@attributes":{"ValidYN":"Y"},"LastName":"Pearce-Kelling","ForeName":"Susan E","Initials":"SE"},{"@attributes":{"ValidYN":"Y"},"LastName":"Miller","ForeName":"Brian J","Initials":"BJ"},{"@attributes":{"ValidYN":"Y"},"LastName":"Jacobson","ForeName":"Samuel G","Initials":"SG"},{"@attributes":{"ValidYN":"Y"},"LastName":"Aguirre","ForeName":"Gustavo D","Initials":"GD"},{"@attributes":{"ValidYN":"Y"},"LastName":"Acland","ForeName":"Gregory M","Initials":"GM"}]},"Language":["eng"],"DataBankList":{"@attributes":{"CompleteYN":"Y"},"DataBank":[{"DataBankName":"GENBANK","AccessionNumberList":{"AccessionNumber":["AY092841"]}}]},"GrantList":{"@attributes":{"CompleteYN":"Y"},"Grant":[{"GrantID":"EY13203","Acronym":"EY","Agency":"NEI NIH HHS","Country":"United States"},{"GrantID":"EY05627","Acronym":"EY","Agency":"NEI NIH HHS","Country":"United States"},{"GrantID":"EY13369","Acronym":"EY","Agency":"NEI NIH HHS","Country":"United States"},{"GrantID":"R01 EY006855","Acronym":"EY","Agency":"NEI NIH HHS","Country":"United States"},{"GrantID":"EY06855","Acronym":"EY","Agency":"NEI NIH HHS","Country":"United States"},{"GrantID":"R01 EY013132","Acronym":"EY","Agency":"NEI NIH HHS","Country":"United States"},{"GrantID":"R01 EY013203","Acronym":"EY","Agency":"NEI NIH HHS","Country":"United States"},{"GrantID":"EY13132","Acronym":"EY","Agency":"NEI NIH HHS","Country":"United States"}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D013485"},"@text":"Research Support, Non-U.S. Gov't"},{"@attributes":{"UI":"D013487"},"@text":"Research Support, U.S. Gov't, P.H.S."}]},"ArticleDate":[{"@attributes":{"DateType":"Electronic"},"Year":"2002","Month":"04","Day":"23"}]},"MedlineJournalInfo":{"Country":"United States","MedlineTA":"Proc Natl Acad Sci U S A","NlmUniqueID":"7505876","ISSNLinking":"0027-8424"},"ChemicalList":{"Chemical":[{"RegistryNumber":"9009-81-8","NameOfSubstance":{"@attributes":{"UI":"D012243"},"@text":"Rhodopsin"}}]},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D002462","MajorTopicYN":"N"},"@text":"Cell Membrane"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D004252","MajorTopicYN":"N"},"@text":"DNA Mutational Analysis"}},{"DescriptorName":{"@attributes":{"UI":"D004285","MajorTopicYN":"N"},"@text":"Dogs"}},{"DescriptorName":{"@attributes":{"UI":"D004596","MajorTopicYN":"N"},"@text":"Electroretinography"}},{"DescriptorName":{"@attributes":{"UI":"D005799","MajorTopicYN":"N"},"@text":"Genes, Dominant"}},{"DescriptorName":{"@attributes":{"UI":"D008040","MajorTopicYN":"N"},"@text":"Genetic Linkage"}},{"DescriptorName":{"@attributes":{"UI":"D006801","MajorTopicYN":"N"},"@text":"Humans"}},{"DescriptorName":{"@attributes":{"UI":"D007150","MajorTopicYN":"N"},"@text":"Immunohistochemistry"}},{"DescriptorName":{"@attributes":{"UI":"D008969","MajorTopicYN":"N"},"@text":"Molecular Sequence Data"}},{"DescriptorName":{"@attributes":{"UI":"D009154","MajorTopicYN":"Y"},"@text":"Mutation"}},{"DescriptorName":{"@attributes":{"UI":"D010641","MajorTopicYN":"N"},"@text":"Phenotype"}},{"DescriptorName":{"@attributes":{"UI":"D010786","MajorTopicYN":"N"},"@text":"Photoreceptor Cells"}},{"DescriptorName":{"@attributes":{"UI":"D017354","MajorTopicYN":"N"},"@text":"Point Mutation"}},{"DescriptorName":{"@attributes":{"UI":"D017433","MajorTopicYN":"N"},"@text":"Protein Structure, Secondary"}},{"DescriptorName":{"@attributes":{"UI":"D012174","MajorTopicYN":"N"},"@text":"Retinitis Pigmentosa"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D012243","MajorTopicYN":"N"},"@text":"Rhodopsin"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D013997","MajorTopicYN":"N"},"@text":"Time Factors"}},{"DescriptorName":{"@attributes":{"UI":"D014054","MajorTopicYN":"N"},"@text":"Tomography"}},{"DescriptorName":{"@attributes":{"UI":"D014960","MajorTopicYN":"N"},"@text":"X Chromosome"}}]}},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"pubmed"},"Year":"2002","Month":"4","Day":"25","Hour":"10","Minute":"0"},{"@attributes":{"PubStatus":"medline"},"Year":"2002","Month":"6","Day":"12","Hour":"10","Minute":"1"},{"@attributes":{"PubStatus":"entrez"},"Year":"2002","Month":"4","Day":"25","Hour":"10","Minute":"0"},{"@attributes":{"PubStatus":"pmc-release"},"Year":"2002","Month":"10","Day":"30"}]},"PublicationStatus":"ppublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"11972042"},{"@attributes":{"IdType":"pmc"},"@text":"PMC122948"},{"@attributes":{"IdType":"doi"},"@text":"10.1073\/pnas.082714499"},{"@attributes":{"IdType":"pii"},"@text":"082714499"}]},"ReferenceList":[{"Reference":[{"Citation":"Spiegel A M. Annu Rev Physiol. 1995;58:143\u2013170.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"8815789"}]}},{"Citation":"Rattner A, Sun H, Nathans J. Annu Rev Genet. 1999;33:89\u2013131.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"10690405"}]}},{"Citation":"Palczewski K, Kumasaka T, Hori T, Behnke C A, Motoshima H, Fox B A, Le Trong I, Teller D C, Okada T, Stenkamp R E, et al. Science. 2000;289:739\u2013745.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"10926528"}]}},{"Citation":"Gal A, Apfelstedt-Sylla E, Janecke A R, Zrenner E. Prog Ret Eye Res. 1997;16:51\u201379."},{"Citation":"Cideciyan A V, Hood D C, Huang Y, Banin E, Li Z-Y, Stone E M, Milam A H, Jacobson S G. Proc Natl Acad Sci USA. 1998;95:7103\u20137108.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC22754"},{"@attributes":{"IdType":"pubmed"},"@text":"9618546"}]}},{"Citation":"Heckenlively J R, Rodriguez J A, Daiger S P. Arch Ophthalmol. 1991;109:84\u201391.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"1987955"}]}},{"Citation":"Li Z-Y, Jacobson S G, Milam A H. Exp Eye Res. 1994;58:397\u2013408.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"7925677"}]}},{"Citation":"Menon S T, Han M, Sakmar T P. Physiol Rev. 2001;81:1659\u20131688.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"11581499"}]}},{"Citation":"Acland G M, Ray K, Mellersh C S, Gu W, Langston A A, Rine J, Ostrander E A, Aguirre G D. Proc Natl Acad Sci USA. 1998;95:3048\u20133053.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC19692"},{"@attributes":{"IdType":"pubmed"},"@text":"9501213"}]}},{"Citation":"Acland G, Ray K, Mellersh C, Langston A, Rine J, Ostrander E, Aguirre G. Genomics. 1999;59:134\u2013142.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"10409424"}]}},{"Citation":"Aguirre G, Baldwin V, Pearce-Kelling S, Narfstrom S, Ray K, Acland G. Mol Vis. 1998;4:23\u201329.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"9808841"}]}},{"Citation":"Aguirre G, Baldwin V, Weeks K, Acland G, Ray K. J Hered. 1999;90:143\u2013147.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"9987922"}]}},{"Citation":"Zhang Q, Acland G M, Zangerl B, Johnson J L, Mao Z, Zeiss C J, Ostrander E A, Aguirre G D. Invest Ophthalmol Visual Sci. 2001;42:2466\u20132471.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"11581184"}]}},{"Citation":"Gould D J, Peterson-Jones S M, Sohal A, Barnett K C, Sargan D R. Anim Genet. 1995;26:261\u2013267.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"7661398"}]}},{"Citation":"Acland G M, Aguirre G D. Exp Eye Res. 1987;44:491\u2013521.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"3496233"}]}},{"Citation":"Acland G M, Aguirre G D, Ray J, Zhang Q, Aleman T S, Cideciyan A V, Pearce-Kelling S E, Anand V, Zeng Y, Maguire A M, et al. Nat Genet. 2001;28:92\u201395.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"11326284"}]}},{"Citation":"Cideciyan A V. Methods Enzymol. 2000;316:611\u2013626.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"10800705"}]}},{"Citation":"Cideciyan A V, Jacobson S G. Vision Res. 1996;36:2609\u20132621.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"8917821"}]}},{"Citation":"Pugh E N, Jr, Lamb T D. Biochim Biophys Acta. 1993;1141:111\u2013149.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"8382952"}]}},{"Citation":"Murphy C J, Howland H C. Vision Res. 1987;27:599\u2013607.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"3660621"}]}},{"Citation":"Huang D, Swanson E A, Lin C P, Schuman J S, Stinson W G, Chang W, Hee M R, Flotte T, Gregory K, Puliafito C A, et al. Science. 1991;254:1178\u20131181.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC4638169"},{"@attributes":{"IdType":"pubmed"},"@text":"1957169"}]}},{"Citation":"Huang Y, Cideciyan A V, Papastergiou G I, Banin E, Semple-Rowland S L, Milam A H, Jacobson S G. Invest Ophthalmol Visual Sci. 1998;39:2405\u20132416.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"9804149"}]}},{"Citation":"Huang Y, Cideciyan A V, Aleman T S, Banin E, Huang J, Syed N A, Petters R M, Wong F, Milam A H, Jacobson S G. Exp Eye Res. 2000;70:247\u2013251.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"10655151"}]}},{"Citation":"Huang J, Mieziewska K, Philp N, van Veen T, Aguirre G. J Neurosci Methods. 1993;47:227\u2013234.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"8271821"}]}},{"Citation":"Aguirre G D, Acland G M. Exp Eye Res. 1988;46:663\u2013687.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"3164273"}]}},{"Citation":"Adamus G, Zam Z S, Arendt A, Palczewski K, McDowell J H, Hargrave P A. Vision Res. 1991;31:17\u201331.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"2006550"}]}},{"Citation":"Jacobson S G, Kemp C M, Sung C-H, Nathans J. Am J Ophthalmol. 1991;112:256\u2013271.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"1882937"}]}},{"Citation":"Kemp C M, Jacobson S G, Roman A J, Sung C-H, Nathans J. Am J Ophthalmol. 1992;113:165\u2013174.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"1550184"}]}},{"Citation":"Cideciyan A V, Haeseleer F, Fariss R N, Aleman T S, Jang G F, Verlinde C L, Marmor M F, Jacobson S G, Palczewski K. Visual Neurosci. 2000;17:667\u2013678.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC1410813"},{"@attributes":{"IdType":"pubmed"},"@text":"11153648"}]}},{"Citation":"Jacobson S G, Cideciyan A V, Iannaccone A, Weleber R G, Fishman G A, Maguire A M, Affatigato L M, Bennett J, Pierce E A, Danciger M, et al. Invest Ophthalmol Visual Sci. 2000;41:1898\u20131908.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"10845615"}]}},{"Citation":"Bunge S, Wedemann H, David D, Terwilliger D J, van den Born L I, Aulehla-Scholz C, Samanns C, Horn M, Ott J, Schwinger E, et al. Genomics. 1993;17:230\u2013233.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"8406457"}]}},{"Citation":"Thomas M M, Lamb T D. J Physiol. 1999;518:479\u2013496.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC2269441"},{"@attributes":{"IdType":"pubmed"},"@text":"10381594"}]}},{"Citation":"Stone E M, Kimura A E, Nichols B E, Khadivi P, Fishman G A, Sheffield V C. Ophthalmology. 1991;98:1806\u20131813.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"1775314"}]}},{"Citation":"Cha K, Reeves P J, Khorana H G. Proc Natl Acad Sci USA. 2000;97:3016\u20133021.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC16184"},{"@attributes":{"IdType":"pubmed"},"@text":"10737783"}]}},{"Citation":"Ferretti L, Karnik S S, Khorana H G, Nassal M, Oprian D D. Proc Natl Acad Sci USA. 1986;83:599\u2013603.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC322911"},{"@attributes":{"IdType":"pubmed"},"@text":"3456156"}]}},{"Citation":"Sung C-H, Schneider B G, Agarwal N, Papermaster D S, Nathans J. Proc Natl Acad Sci USA. 1991;88:8840\u20138844.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC52606"},{"@attributes":{"IdType":"pubmed"},"@text":"1924344"}]}},{"Citation":"Garriga P, Liu X, Khorana H G. Proc Natl Acad Sci USA. 1996;93:4560\u20134564.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC39316"},{"@attributes":{"IdType":"pubmed"},"@text":"8643443"}]}},{"Citation":"Stiles W S, Crawford B H Phys. Soc. London, editors. Report of a Joint Discussion on Vision. Cambridge, U.K.: Cambridge Univ. Press; 1932. pp. 194\u2013211."},{"Citation":"Dowling J. Nature (London) 1960;188:114\u2013118.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"13724150"}]}},{"Citation":"Barlow H B. Vision Res. 1964;4:47\u201358.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"5888595"}]}},{"Citation":"Lamb T D. Vision Res. 1981;21:1773\u20131782.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"7336615"}]}},{"Citation":"Leibrock C S, Reuter T, Lamb T D. Eye. 1998;12:511\u2013520.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"9775211"}]}},{"Citation":"Kennedy M J, Lee K A, Niemi G A, Craven K B, Garwin G G, Saari J C, Hurley J B. Neuron. 2001;31:87\u2013101.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"11498053"}]}},{"Citation":"Fain G L, Matthews H R, Cornwall M C, Koutalos Y. Physiol Rev. 2001;81:117\u2013151.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"11152756"}]}},{"Citation":"Rando R R. Chem Rev. 2001;101:1881\u20131896.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"11710234"}]}},{"Citation":"Grimm C, Reme C E, Rol P O, Williams T P. Invest Ophthalmol Visual Sci. 2000;41:3984\u20133990.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"11053303"}]}},{"Citation":"Naash M I, Peachey N S, Li Z-Y, Gryczan C C, Goto Y, Blanks J, Milam A H, Ripps H. Invest Ophthalmol Visual Sci. 1996;37:775\u2013782.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"8603862"}]}},{"Citation":"Chen C-K, Burns M E, Spencer M, Niemi G A, Chen J, Hurley J B, Baylor D A, Simon M I. Proc Natl Acad Sci USA. 1999;96:3718\u20133722.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC22360"},{"@attributes":{"IdType":"pubmed"},"@text":"10097103"}]}},{"Citation":"Choi S, Hao W, Chen C-K, Simon M I. Proc Natl Acad Sci USA. 2001;98:13096\u201313101.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC60830"},{"@attributes":{"IdType":"pubmed"},"@text":"11687607"}]}},{"Citation":"Timmers A M, Wintjes E T, Hauswirth W W. Invest Ophthalmol Visual Sci. 1995;36:2008\u20132019.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"7544781"}]}},{"Citation":"van Ginkel P R, Timmers A M, Szel A, Hauswirth W W. Dev Brain Res. 1995;89:146\u2013149.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"8575088"}]}},{"Citation":"Sakuta H, Suzuki R, Takahashi H, Kato A, Shintani T, Iemura S, Yamamoto T S, Ueno N, Noda M. Science. 2001;293:111\u2013115.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"11441185"}]}},{"Citation":"Kumaramanickavel G, Maw M, Denton M J, John S, Srikumari C R S, Orth U, Oehlmann R, Gal A. Nat Genet. 1994;8:10\u201311.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"7987385"}]}},{"Citation":"Ayuso C, Trujillo M J, Robledo M, Ramos C, Benitez J, Martin-Oses F, del Rio T, Garcia-Sandoval B. Hum Genet. 1996;98:51\u201354.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"8682506"}]}},{"Citation":"Reig C, Trujillo M J, Martinez-Gimeno M, Garcia-Sandoval B, Calvo M T, Ayuso C, Carballo M. Ophthalmic Genet. 2000;21:79\u201387.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"10916182"}]}},{"Citation":"Li T, Sandberg M A, Pawlyk B S, Rosner B, Hayes K C, Dryja T P, Berson E L. Proc Natl Acad Sci USA. 1998;95:11933\u201311938.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC21743"},{"@attributes":{"IdType":"pubmed"},"@text":"9751768"}]}},{"Citation":"Lewin A S, Drenser K A, Hauswirth W W, Nishikawa S, Yasumura D, Flannery J G, LaVail M M. Nat Med. 1998;8:967\u2013971.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"9701253"}]}}]}]}}}