{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"11978826"},"DateCompleted":{"Year":"2002","Month":"05","Day":"20"},"DateRevised":{"Year":"2019","Month":"12","Day":"10"},"Article":{"@attributes":{"PubModel":"Print"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Electronic"},"@text":"1529-2401"},"JournalIssue":{"@attributes":{"CitedMedium":"Internet"},"Volume":"22","Issue":"9","PubDate":{"Year":"2002","Month":"May","Day":"01"}},"Title":"The Journal of neuroscience : the official journal of the Society for Neuroscience","ISOAbbreviation":"J Neurosci"},"ArticleTitle":"Differential palmitoylation directs the AMPA receptor-binding protein ABP to spines or to intracellular clusters.","Pagination":{"StartPage":"3493","EndPage":"3503","MedlinePgn":"3493-503"},"Abstract":{"AbstractText":["Long-term changes in excitatory synapse strength are thought to reflect changes in synaptic abundance of AMPA receptors mediated by receptor trafficking. AMPA receptor-binding protein (ABP) and glutamate receptor-interacting protein (GRIP) are two similar PDZ (postsynaptic density 95\/Discs large\/zona occludens 1) proteins that interact with glutamate receptors 2 and 3 (GluR2 and GluR3) subunits. Both proteins have proposed roles during long-term potentiation and long-term depression in the delivery and anchorage of AMPA receptors at synapses. Here we report a variant of ABP-L (seven PDZ form of ABP) called pABP-L that is palmitoylated at a cysteine residue at position 11 within a novel 18 amino acid N-terminal leader sequence encoded through differential splicing. In cultured hippocampal neurons, nonpalmitoylated ABP-L localizes with internal GluR2 pools expressed from a Sindbis virus vector, whereas pABP-L is membrane targeted and associates with surface-localized GluR2 receptors at the plasma membrane in spines. Mutation of Cys-11 to alanine blocks the palmitoylation of pABP-L and targets the protein to intracellular clusters, confirming that targeting the protein to spines is dependent on palmitoylation. Non-palmitoylated GRIP is primarily intracellular, but a chimera with the pABP-L N-terminal palmitoylation sequence linked to the body of the GRIP protein is targeted to spines. We suggest that pABP-L and ABP-L provide, respectively, synaptic and intracellular sites for the anchorage of AMPA receptors during receptor trafficking to and from the synapse."]},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"DeSouza","ForeName":"Sunita","Initials":"S","AffiliationInfo":[{"Affiliation":"Howard Hughes Medical Institute, Department of Biochemistry, New York University School of Medicine, New York, New York 10016, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Fu","ForeName":"Jie","Initials":"J"},{"@attributes":{"ValidYN":"Y"},"LastName":"States","ForeName":"Bradley A","Initials":"BA"},{"@attributes":{"ValidYN":"Y"},"LastName":"Ziff","ForeName":"Edward B","Initials":"EB"}]},"Language":["eng"],"GrantList":{"@attributes":{"CompleteYN":"Y"},"Grant":[{"GrantID":"R01 AG013620","Acronym":"AG","Agency":"NIA NIH HHS","Country":"United States"},{"GrantID":"R37 AG013620","Acronym":"AG","Agency":"NIA NIH HHS","Country":"United States"},{"GrantID":"AG13620","Acronym":"AG","Agency":"NIA NIH HHS","Country":"United States"}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D013485"},"@text":"Research Support, Non-U.S. Gov't"},{"@attributes":{"UI":"D013487"},"@text":"Research Support, U.S. Gov't, P.H.S."}]}},"MedlineJournalInfo":{"Country":"United States","MedlineTA":"J Neurosci","NlmUniqueID":"8102140","ISSNLinking":"0270-6474"},"ChemicalList":{"Chemical":[{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D048868"},"@text":"Adaptor Proteins, Signal Transducing"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D002352"},"@text":"Carrier Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C485566"},"@text":"GRIP2 protein, human"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C118486"},"@text":"Grip2 protein, rat"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D036341"},"@text":"Intercellular Signaling Peptides and Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D046911"},"@text":"Macromolecular Substances"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D009419"},"@text":"Nerve Tissue Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D051958"},"@text":"Nuclear Receptor Coactivator 2"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D010169"},"@text":"Palmitic Acids"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D020033"},"@text":"Protein Isoforms"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D012333"},"@text":"RNA, Messenger"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D018091"},"@text":"Receptors, AMPA"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D011993"},"@text":"Recombinant Fusion Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D014157"},"@text":"Transcription Factors"}},{"RegistryNumber":"P6W5IXV8V9","NameOfSubstance":{"@attributes":{"UI":"C104722"},"@text":"glutamate receptor ionotropic, AMPA 2"}}]},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D048868","MajorTopicYN":"N"},"@text":"Adaptor Proteins, Signal Transducing"}},{"DescriptorName":{"@attributes":{"UI":"D017398","MajorTopicYN":"N"},"@text":"Alternative Splicing"}},{"DescriptorName":{"@attributes":{"UI":"D000595","MajorTopicYN":"N"},"@text":"Amino Acid Sequence"}},{"DescriptorName":{"@attributes":{"UI":"D019943","MajorTopicYN":"N"},"@text":"Amino Acid Substitution"}},{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D002352","MajorTopicYN":"N"},"@text":"Carrier 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Reporter"}},{"DescriptorName":{"@attributes":{"UI":"D006801","MajorTopicYN":"N"},"@text":"Humans"}},{"DescriptorName":{"@attributes":{"UI":"D036341","MajorTopicYN":"N"},"@text":"Intercellular Signaling Peptides and Proteins"}},{"DescriptorName":{"@attributes":{"UI":"D007424","MajorTopicYN":"N"},"@text":"Intracellular Fluid"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D007668","MajorTopicYN":"N"},"@text":"Kidney"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"N"},"@text":"cytology"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D046911","MajorTopicYN":"N"},"@text":"Macromolecular Substances"}},{"DescriptorName":{"@attributes":{"UI":"D008297","MajorTopicYN":"N"},"@text":"Male"}},{"DescriptorName":{"@attributes":{"UI":"D008969","MajorTopicYN":"N"},"@text":"Molecular Sequence 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Acids"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D020033","MajorTopicYN":"N"},"@text":"Protein Isoforms"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D021381","MajorTopicYN":"N"},"@text":"Protein Transport"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"N"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D012333","MajorTopicYN":"N"},"@text":"RNA, Messenger"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D051381","MajorTopicYN":"N"},"@text":"Rats"}},{"DescriptorName":{"@attributes":{"UI":"D017207","MajorTopicYN":"N"},"@text":"Rats, Sprague-Dawley"}},{"DescriptorName":{"@attributes":{"UI":"D018091","MajorTopicYN":"N"},"@text":"Receptors, AMPA"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D011993","MajorTopicYN":"N"},"@text":"Recombinant Fusion Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D014157","MajorTopicYN":"N"},"@text":"Transcription Factors"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D014162","MajorTopicYN":"N"},"@text":"Transfection"}}]}},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"pubmed"},"Year":"2002","Month":"4","Day":"30","Hour":"10","Minute":"0"},{"@attributes":{"PubStatus":"medline"},"Year":"2002","Month":"5","Day":"22","Hour":"10","Minute":"1"},{"@attributes":{"PubStatus":"entrez"},"Year":"2002","Month":"4","Day":"30","Hour":"10","Minute":"0"},{"@attributes":{"PubStatus":"pmc-release"},"Year":"2002","Month":"11","Day":"1"}]},"PublicationStatus":"ppublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"11978826"},{"@attributes":{"IdType":"pmc"},"@text":"PMC6758378"},{"@attributes":{"IdType":"pii"},"@text":"22\/9\/3493"},{"@attributes":{"IdType":"doi"},"@text":"10.1523\/JNEUROSCI.22-09-03493.2002"}]},"ReferenceList":[{"Reference":[{"Citation":"Alland 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