{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"12469125"},"DateCompleted":{"Year":"2003","Month":"03","Day":"07"},"DateRevised":{"Year":"2019","Month":"12","Day":"10"},"Article":{"@attributes":{"PubModel":"Print"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Print"},"@text":"1097-6256"},"JournalIssue":{"@attributes":{"CitedMedium":"Print"},"Volume":"6","Issue":"1","PubDate":{"Year":"2003","Month":"Jan"}},"Title":"Nature neuroscience","ISOAbbreviation":"Nat Neurosci"},"ArticleTitle":"Zinc finger protein too few controls the development of monoaminergic neurons.","Pagination":{"StartPage":"28","EndPage":"33","MedlinePgn":"28-33"},"Abstract":{"AbstractText":["The mechanism controlling the development of dopaminergic (DA) and serotonergic (5HT) neurons in vertebrates is not well understood. Here we characterized a zebrafish mutant--too few (tof)--that develops hindbrain 5HT and noradrenergic neurons, but does not develop hypothalamic DA and 5HT neurons. tof encodes a forebrain-specific zinc finger transcription repressor that is homologous to the mammalian Fezl (forebrain embryonic zinc finger-like protein). Mosaic and co-staining analyses showed that fezl was not expressed in DA or 5HT neurons and instead controlled development of these neurons non-cell-autonomously. Both the eh1-related repressor motif and the second zinc finger domain were necessary for tof function. Our results indicate that tof\/fezl is a key component in regulating the development of monoaminergic neurons in the vertebrate brain."]},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Levkowitz","ForeName":"Gil","Initials":"G","AffiliationInfo":[{"Affiliation":"Rinat Neuroscience Corporation, 3155 Porter Drive, Palo Alto, California 94304, USA. gillev@rinatneuro.com"}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Zeller","ForeName":"J\u00f6rg","Initials":"J"},{"@attributes":{"ValidYN":"Y"},"LastName":"Sirotkin","ForeName":"Howard I","Initials":"HI"},{"@attributes":{"ValidYN":"Y"},"LastName":"French","ForeName":"Dorothy","Initials":"D"},{"@attributes":{"ValidYN":"Y"},"LastName":"Schilbach","ForeName":"Sarah","Initials":"S"},{"@attributes":{"ValidYN":"Y"},"LastName":"Hashimoto","ForeName":"Hisashi","Initials":"H"},{"@attributes":{"ValidYN":"Y"},"LastName":"Hibi","ForeName":"Masahiko","Initials":"M"},{"@attributes":{"ValidYN":"Y"},"LastName":"Talbot","ForeName":"William S","Initials":"WS"},{"@attributes":{"ValidYN":"Y"},"LastName":"Rosenthal","ForeName":"Arnon","Initials":"A"}]},"Language":["eng"],"GrantList":{"@attributes":{"CompleteYN":"Y"},"Grant":[{"GrantID":"RR12349","Acronym":"RR","Agency":"NCRR NIH HHS","Country":"United States"}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D013485"},"@text":"Research Support, Non-U.S. Gov't"},{"@attributes":{"UI":"D013487"},"@text":"Research Support, U.S. Gov't, P.H.S."}]}},"MedlineJournalInfo":{"Country":"United States","MedlineTA":"Nat Neurosci","NlmUniqueID":"9809671","ISSNLinking":"1097-6256"},"ChemicalList":{"Chemical":[{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D000900"},"@text":"Anti-Bacterial Agents"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D015306"},"@text":"Biogenic Monoamines"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D002352"},"@text":"Carrier Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D054848"},"@text":"Peptaibols"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D010455"},"@text":"Peptides"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D012097"},"@text":"Repressor Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D029961"},"@text":"Zebrafish Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C471725"},"@text":"efrapeptin C"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C418489"},"@text":"fezf2 protein, zebrafish"}},{"RegistryNumber":"333DO1RDJY","NameOfSubstance":{"@attributes":{"UI":"D012701"},"@text":"Serotonin"}},{"RegistryNumber":"VTD58H1Z2X","NameOfSubstance":{"@attributes":{"UI":"D004298"},"@text":"Dopamine"}}]},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D000900","MajorTopicYN":"N"},"@text":"Anti-Bacterial Agents"},"QualifierName":[{"@attributes":{"UI":"Q000138","MajorTopicYN":"Y"},"@text":"chemical synthesis"}]},{"DescriptorName":{"@attributes":{"UI":"D017209","MajorTopicYN":"N"},"@text":"Apoptosis"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D015306","MajorTopicYN":"N"},"@text":"Biogenic Monoamines"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D001921","MajorTopicYN":"N"},"@text":"Brain"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"N"},"@text":"cytology"},{"@attributes":{"UI":"Q000196","MajorTopicYN":"Y"},"@text":"embryology"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D016380","MajorTopicYN":"N"},"@text":"Brain Tissue Transplantation"}},{"DescriptorName":{"@attributes":{"UI":"D002352","MajorTopicYN":"N"},"@text":"Carrier Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000302","MajorTopicYN":"Y"},"@text":"isolation & purification"}]},{"DescriptorName":{"@attributes":{"UI":"D002454","MajorTopicYN":"N"},"@text":"Cell Differentiation"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D002874","MajorTopicYN":"N"},"@text":"Chromosome Mapping"}},{"DescriptorName":{"@attributes":{"UI":"D004298","MajorTopicYN":"N"},"@text":"Dopamine"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D004625","MajorTopicYN":"N"},"@text":"Embryo, Nonmammalian"}},{"DescriptorName":{"@attributes":{"UI":"D005260","MajorTopicYN":"N"},"@text":"Female"}},{"DescriptorName":{"@attributes":{"UI":"D018507","MajorTopicYN":"N"},"@text":"Gene Expression Regulation, Developmental"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D008297","MajorTopicYN":"N"},"@text":"Male"}},{"DescriptorName":{"@attributes":{"UI":"D009474","MajorTopicYN":"N"},"@text":"Neurons"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"N"},"@text":"cytology"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D054848","MajorTopicYN":"N"},"@text":"Peptaibols"}},{"DescriptorName":{"@attributes":{"UI":"D010455","MajorTopicYN":"Y"},"@text":"Peptides"}},{"DescriptorName":{"@attributes":{"UI":"D012097","MajorTopicYN":"N"},"@text":"Repressor Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000302","MajorTopicYN":"N"},"@text":"isolation & purification"}]},{"DescriptorName":{"@attributes":{"UI":"D012701","MajorTopicYN":"N"},"@text":"Serotonin"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D015398","MajorTopicYN":"N"},"@text":"Signal Transduction"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D013234","MajorTopicYN":"N"},"@text":"Stem Cells"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"N"},"@text":"cytology"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D015027","MajorTopicYN":"N"},"@text":"Zebrafish"}},{"DescriptorName":{"@attributes":{"UI":"D029961","MajorTopicYN":"Y"},"@text":"Zebrafish Proteins"}},{"DescriptorName":{"@attributes":{"UI":"D016335","MajorTopicYN":"N"},"@text":"Zinc Fingers"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]}]}},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"received"},"Year":"2002","Month":"9","Day":"23"},{"@attributes":{"PubStatus":"accepted"},"Year":"2002","Month":"10","Day":"24"},{"@attributes":{"PubStatus":"pubmed"},"Year":"2002","Month":"12","Day":"7","Hour":"4","Minute":"0"},{"@attributes":{"PubStatus":"medline"},"Year":"2003","Month":"3","Day":"8","Hour":"4","Minute":"0"},{"@attributes":{"PubStatus":"entrez"},"Year":"2002","Month":"12","Day":"7","Hour":"4","Minute":"0"}]},"PublicationStatus":"ppublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"12469125"},{"@attributes":{"IdType":"doi"},"@text":"10.1038\/nn979"},{"@attributes":{"IdType":"pii"},"@text":"nn979"}]}}}}