{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"16314561"},"DateCompleted":{"Year":"2006","Month":"01","Day":"18"},"DateRevised":{"Year":"2018","Month":"11","Day":"13"},"Article":{"@attributes":{"PubModel":"Print-Electronic"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Print"},"@text":"0027-8424"},"JournalIssue":{"@attributes":{"CitedMedium":"Print"},"Volume":"102","Issue":"49","PubDate":{"Year":"2005","Month":"Dec","Day":"06"}},"Title":"Proceedings of the National Academy of Sciences of the United States of America","ISOAbbreviation":"Proc Natl Acad Sci U S A"},"ArticleTitle":"Zfp312 is required for subcortical axonal projections and dendritic morphology of deep-layer pyramidal neurons of the cerebral cortex.","Pagination":{"StartPage":"17792","EndPage":"17797","MedlinePgn":"17792-7"},"Abstract":{"AbstractText":["Pyramidal neurons of the cerebral cortex display marked layer- and subtype-specific differences in their axonal projections and dendritic morphologies. Here we show that transcription factor Zfp312 is selectively expressed by layer V and VI subcortical projection pyramidal neurons and their progenitor cells. Knocking down Zfp312 with small interfering RNAs dramatically reduced the number of subcortical axonal projections from deep-layer pyramidal neurons and altered their dendritic morphology. In contrast, misexpression of Zfp312 in cortically projecting pyramidal neurons of layers II and III induced the expression of Tbr1, a transcription factor enriched in deep-layer neurons, and the formation of ectopic subcortical axonal projections. Thus, our results indicate that transcription factor Zfp312 plays a critical role in layer- and neuronal subtype-specific patterning of cortical axonal projections and dendritic morphologies."]},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Chen","ForeName":"Jie-Guang","Initials":"JG","AffiliationInfo":[{"Affiliation":"Department of Neurobiology and Kavli Institute for Neuroscience, Yale University School of Medicine, New Haven, CT 06510, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Rasin","ForeName":"Mladen-Roko","Initials":"MR"},{"@attributes":{"ValidYN":"Y"},"LastName":"Kwan","ForeName":"Kenneth Y","Initials":"KY"},{"@attributes":{"ValidYN":"Y"},"LastName":"Sestan","ForeName":"Nenad","Initials":"N"}]},"Language":["eng"],"GrantList":{"@attributes":{"CompleteYN":"Y"},"Grant":[{"GrantID":"R01 HD045481","Acronym":"HD","Agency":"NICHD NIH HHS","Country":"United States"},{"GrantID":"R01 NS054273","Acronym":"NS","Agency":"NINDS NIH HHS","Country":"United States"},{"GrantID":"HD045481","Acronym":"HD","Agency":"NICHD NIH HHS","Country":"United States"},{"GrantID":"NS054273","Acronym":"NS","Agency":"NINDS NIH HHS","Country":"United States"}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D052061"},"@text":"Research Support, N.I.H., Extramural"},{"@attributes":{"UI":"D013485"},"@text":"Research Support, Non-U.S. Gov't"}]},"ArticleDate":[{"@attributes":{"DateType":"Electronic"},"Year":"2005","Month":"11","Day":"28"}]},"MedlineJournalInfo":{"Country":"United States","MedlineTA":"Proc Natl Acad Sci U S A","NlmUniqueID":"7505876","ISSNLinking":"0027-8424"},"ChemicalList":{"Chemical":[{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D004268"},"@text":"DNA-Binding Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D009419"},"@text":"Nerve Tissue Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D034741"},"@text":"RNA, Small Interfering"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C412364"},"@text":"Zfp312 protein, mouse"}}]},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D001369","MajorTopicYN":"N"},"@text":"Axons"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D002460","MajorTopicYN":"N"},"@text":"Cell Line"}},{"DescriptorName":{"@attributes":{"UI":"D002540","MajorTopicYN":"N"},"@text":"Cerebral Cortex"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"Y"},"@text":"cytology"},{"@attributes":{"UI":"Q000196","MajorTopicYN":"N"},"@text":"embryology"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D004268","MajorTopicYN":"N"},"@text":"DNA-Binding Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D003712","MajorTopicYN":"N"},"@text":"Dendrites"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D004622","MajorTopicYN":"N"},"@text":"Embryo, Mammalian"},"QualifierName":[{"@attributes":{"UI":"Q000196","MajorTopicYN":"N"},"@text":"embryology"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D018507","MajorTopicYN":"N"},"@text":"Gene Expression Regulation, Developmental"}},{"DescriptorName":{"@attributes":{"UI":"D051379","MajorTopicYN":"N"},"@text":"Mice"}},{"DescriptorName":{"@attributes":{"UI":"D009419","MajorTopicYN":"N"},"@text":"Nerve Tissue Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D017966","MajorTopicYN":"N"},"@text":"Pyramidal Cells"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"Y"},"@text":"cytology"},{"@attributes":{"UI":"Q000196","MajorTopicYN":"N"},"@text":"embryology"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D034741","MajorTopicYN":"N"},"@text":"RNA, Small Interfering"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D051381","MajorTopicYN":"N"},"@text":"Rats"}}]}},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"pubmed"},"Year":"2005","Month":"11","Day":"30","Hour":"9","Minute":"0"},{"@attributes":{"PubStatus":"medline"},"Year":"2006","Month":"1","Day":"19","Hour":"9","Minute":"0"},{"@attributes":{"PubStatus":"entrez"},"Year":"2005","Month":"11","Day":"30","Hour":"9","Minute":"0"},{"@attributes":{"PubStatus":"pmc-release"},"Year":"2006","Month":"6","Day":"6"}]},"PublicationStatus":"ppublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"16314561"},{"@attributes":{"IdType":"pmc"},"@text":"PMC1308928"},{"@attributes":{"IdType":"doi"},"@text":"10.1073\/pnas.0509032102"},{"@attributes":{"IdType":"pii"},"@text":"0509032102"}]},"ReferenceList":[{"Reference":[{"Citation":"DeFelipe, J. &amp; Farinas, I. (1992) Prog. Neurobiol. 39<b>,<\/b> 563-607.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"1410442"}]}},{"Citation":"O'Leary, D. D. &amp; Koester, S. E. (1993) Neuron 10<b>,<\/b> 991-1006.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"8318235"}]}},{"Citation":"Hevner, R. F., Daza, R. A., Rubenstein, J. L., Stunnenberg, H., Olavarria, J. F. &amp; Englund, C. (2003) Dev. Neurosci. 25<b>,<\/b> 139-151.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"12966212"}]}},{"Citation":"Whitford, K. L., Dijkhuizen, P., Polleux, F. &amp; Ghosh, A. (2002) Annu. Rev. Neurosci. 25<b>,<\/b> 127-149.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"12052906"}]}},{"Citation":"Koester, S. E. &amp; O'Leary, D. D. (1993) J. Neurosci. 12<b>,<\/b> 1382-1393.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC6575798"},{"@attributes":{"IdType":"pubmed"},"@text":"1556599"}]}},{"Citation":"Caviness, V. S., Jr. (1982) Brain Res. 256<b>,<\/b> 293-302.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"7104762"}]}},{"Citation":"Jensen, K. F. &amp; Killackey, H. P. (1984) Proc. Natl. Acad. Sci. USA 81<b>,<\/b> 964-968.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC344960"},{"@attributes":{"IdType":"pubmed"},"@text":"6583692"}]}},{"Citation":"Frantz, G. D. &amp; McConnell, S. K. (1996) Neuron 17<b>,<\/b> 55-61.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"8755478"}]}},{"Citation":"McEvilly, R. J., de Diaz, M. O., Schonemann, M. D., Hooshmand, F. &amp; Rosenfeld, M. G. (2002) Science 295<b>,<\/b> 1528-1532.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"11859196"}]}},{"Citation":"Weimann, J. M., Zhang, Y. A., Levin, M. E., Devine, W. P., Brulet, P. &amp; McConnell, S. K. (1999) Neuron 24<b>,<\/b> 819-831.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"10624946"}]}},{"Citation":"Gray, P. A., Fu, H., Luo, P., Zhao, Q., Yu, J., Ferrari, A., Tenzen, T., Yuk, D. I., Tsung, E. F., Cai, Z., <i>et al.<\/i> (2004) Science 306<b>,<\/b> 2255-2257.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"15618518"}]}},{"Citation":"Arlotta, P., Molyneaux, B. J., Chen, J., Inoue, J., Kominami, R. &amp; Macklis, J. D. (2005) Neuron 45<b>,<\/b> 207-221.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"15664173"}]}},{"Citation":"Roncarati, R., Sestan, N., Scheinfeld, M. H., Berechid, B. E., Lopez, P. A., Meucci, O., McGlade, J. C., Rakic, P. &amp; D'Adamio, L. (2002) Proc. Natl. Acad. Sci. USA 99<b>,<\/b> 7102-7107.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC124535"},{"@attributes":{"IdType":"pubmed"},"@text":"12011466"}]}},{"Citation":"Saito, T. &amp; Nakatsuji, N. (2001) Dev. Biol. 240<b>,<\/b> 237-246.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"11784059"}]}},{"Citation":"Sestan, N., Artavanis-Tsakonas, S. &amp; Rakic, P. (1999) Science 286<b>,<\/b> 741-746.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"10531053"}]}},{"Citation":"Hirata, T., Suda, Y., Nakao, K., Narimatsu, M., Hirano, T. &amp; Hibi, M. (2004) Dev. Dyn. 230<b>,<\/b> 546-556.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"15188439"}]}},{"Citation":"Inoue, K., Terashima, T., Nishikawa, T. &amp; Takumi, T. (2004) Eur. J. Neurosci. 20<b>,<\/b> 2909-2916.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"15579145"}]}},{"Citation":"Matsuo-Takasaki, M., Lim, J. H., Beanan, M. J., Sato, S. M. &amp; Sargent, T. D. (2000) Mech. Dev. 93<b>,<\/b> 201-204.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"10781957"}]}},{"Citation":"Hashimoto, H., Yabe, T., Hirata, T., Shimizu, T., Bae, Y., Yamanaka, Y., Hirano, T. &amp; Hibi, M. (2000) Mech. Dev. 97<b>,<\/b> 191-195.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"11025224"}]}},{"Citation":"Yang, Z., Liu, N. &amp; Lin, S. (2001) Dev. Biol. 231<b>,<\/b> 138-148.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"11180958"}]}},{"Citation":"Levkowitz, G., Zeller, J., Sirotkin, H. I., French, D., Schilbach, S., Hashimoto, H., Hibi, M., Talbot, W. S. &amp; Rosenthal, A. (2003) Nat. Neurosci. 6<b>,<\/b> 28-33.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"12469125"}]}},{"Citation":"Sansom, S. N., Hebert, J. M., Thammongkol, U., Smith, J., Nisbet, G., Surani, M. A., McConnell, S. K. &amp; Livesey, F. J. (2005) Development (Cambridge, U.K.) 132<b>,<\/b> 3947-3961.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC4729368"},{"@attributes":{"IdType":"pubmed"},"@text":"16079153"}]}},{"Citation":"Polleux, F., Dehay, C. &amp; Kennedy, H. (1998) J. Neurosci. 18<b>,<\/b> 9910-9923.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC6793302"},{"@attributes":{"IdType":"pubmed"},"@text":"9822747"}]}},{"Citation":"Hevner, R. F., Shi, L., Justice, N., Hsueh, Y., Sheng, M., Smiga, S., Bulfone, A., Goffinet, A. M., Campagnoni, A. T. &amp; Rubenstein, J. L. (2001) Neuron 29<b>,<\/b> 353-366.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"11239428"}]}},{"Citation":"Lopez-Bendito, G. &amp; Molnar, Z. (2003) Nat. Rev. Neurosci. 4<b>,<\/b> 276-289.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"12671644"}]}},{"Citation":"Rouiller, E. M. &amp; Welker, E. (2000) Brain Res. Bull. 53<b>,<\/b> 727-741.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"11179837"}]}},{"Citation":"Molyneaux, B. J., Arlotta, P., Hirata, T., Hibi, M. &amp; Macklis, J. D. (2005) Neuron 47<b>,<\/b> 817-831.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"16157277"}]}}]}]}}}