{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"16415889"},"DateCompleted":{"Year":"2006","Month":"04","Day":"04"},"DateRevised":{"Year":"2025","Month":"05","Day":"29"},"Article":{"@attributes":{"PubModel":"Print-Electronic"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Print"},"@text":"1061-4036"},"JournalIssue":{"@attributes":{"CitedMedium":"Print"},"Volume":"38","Issue":"2","PubDate":{"Year":"2006","Month":"Feb"}},"Title":"Nature genetics","ISOAbbreviation":"Nat Genet"},"ArticleTitle":"Physiogenomic resources for rat models of heart, lung and blood disorders.","Pagination":{"StartPage":"234","EndPage":"239","MedlinePgn":"234-9"},"Abstract":{"AbstractText":["Cardiovascular disorders are influenced by genetic and environmental factors. The TIGR rodent expression web-based resource (TREX) contains over 2,200 microarray hybridizations, involving over 800 animals from 18 different rat strains. These strains comprise genetically diverse parental animals and a panel of chromosomal substitution strains derived by introgressing individual chromosomes from normotensive Brown Norway (BN\/NHsdMcwi) rats into the background of Dahl salt sensitive (SS\/JrHsdMcwi) rats. The profiles document gene-expression changes in both genders, four tissues (heart, lung, liver, kidney) and two environmental conditions (normoxia, hypoxia). This translates into almost 400 high-quality direct comparisons (not including replicates) and over 100,000 pairwise comparisons. As each individual chromosomal substitution strain represents on average less than a 5% change from the parental genome, consomic strains provide a useful mechanism to dissect complex traits and identify causative genes. We performed a variety of data-mining manipulations on the profiles and used complementary physiological data from the PhysGen resource to demonstrate how TREX can be used by the cardiovascular community for hypothesis generation."]},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Malek","ForeName":"Renae L","Initials":"RL","AffiliationInfo":[{"Affiliation":"TREX, The Institute for Genomic Research, 9712 Medical Center Drive, Rockville, Maryland 20850, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Wang","ForeName":"Hong-ying","Initials":"HY"},{"@attributes":{"ValidYN":"Y"},"LastName":"Kwitek","ForeName":"Anne E","Initials":"AE"},{"@attributes":{"ValidYN":"Y"},"LastName":"Greene","ForeName":"Andrew 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H","Initials":"NH"}]},"Language":["eng"],"GrantList":{"@attributes":{"CompleteYN":"Y"},"Grant":[{"GrantID":"R01 LM006845","Acronym":"LM","Agency":"NLM NIH HHS","Country":"United States"},{"GrantID":"U01 HL066619","Acronym":"HL","Agency":"NHLBI NIH HHS","Country":"United States"}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D052061"},"@text":"Research Support, N.I.H., Extramural"}]},"ArticleDate":[{"@attributes":{"DateType":"Electronic"},"Year":"2006","Month":"01","Day":"15"}]},"MedlineJournalInfo":{"Country":"United States","MedlineTA":"Nat Genet","NlmUniqueID":"9216904","ISSNLinking":"1061-4036"},"CitationSubset":["IM"],"CommentsCorrectionsList":{"CommentsCorrections":[{"@attributes":{"RefType":"CommentIn"},"RefSource":"Nat Genet. 2006 Feb;38(2):140-1. doi: 10.1038\/ng0206-140.","PMID":{"@attributes":{"Version":"1"},"@text":"16444251"}}]},"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D030541","MajorTopicYN":"Y"},"@text":"Databases, Genetic"}},{"DescriptorName":{"@attributes":{"UI":"D004195","MajorTopicYN":"Y"},"@text":"Disease Models, Animal"}},{"DescriptorName":{"@attributes":{"UI":"D020869","MajorTopicYN":"N"},"@text":"Gene Expression Profiling"}},{"DescriptorName":{"@attributes":{"UI":"D014644","MajorTopicYN":"N"},"@text":"Genetic Variation"}},{"DescriptorName":{"@attributes":{"UI":"D023281","MajorTopicYN":"Y"},"@text":"Genomics"},"QualifierName":[{"@attributes":{"UI":"Q000379","MajorTopicYN":"N"},"@text":"methods"}]},{"DescriptorName":{"@attributes":{"UI":"D006331","MajorTopicYN":"N"},"@text":"Heart 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