{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"16540508"},"DateCompleted":{"Year":"2006","Month":"06","Day":"13"},"DateRevised":{"Year":"2006","Month":"11","Day":"15"},"Article":{"@attributes":{"PubModel":"Print-Electronic"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Print"},"@text":"0950-1991"},"JournalIssue":{"@attributes":{"CitedMedium":"Print"},"Volume":"133","Issue":"8","PubDate":{"Year":"2006","Month":"Apr"}},"Title":"Development (Cambridge, England)","ISOAbbreviation":"Development"},"ArticleTitle":"Zinc-finger gene Fez in the olfactory sensory neurons regulates development of the olfactory bulb non-cell-autonomously.","Pagination":{"StartPage":"1433","EndPage":"1443","MedlinePgn":"1433-43"},"Abstract":{"AbstractText":["Fez is a zinc-finger gene encoding a transcriptional repressor that is expressed in the olfactory epithelium, hypothalamus, ventrolateral pallium and prethalamus at mid-gestation. To reveal its function, we generated Fez-deficient mice. The Fez-deficient mice showed several abnormalities in the olfactory system: (1) impaired axonal projection of the olfactory sensory neurons; (2) reduced size of the olfactory bulb; (3) abnormal layer formation in the olfactory bulb; and (4) aberrant rostral migration of the interneuron progenitors. Fez was not expressed in the projection neurons, interneurons or interneuron progenitors. Transgene-mediated expression of Fez in olfactory sensory neurons significantly rescued the abnormalities in olfactory axon projection and in the morphogenesis of the olfactory bulb in Fez-knockout mice. Thus, Fez is cell-autonomously required for the axon termination of olfactory sensory neurons, and Fez non-cell-autonomously controls layer formation and interneuron development in the olfactory bulb. These findings suggest that signals from olfactory sensory neurons contribute to the proper formation of the olfactory bulb."]},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Hirata","ForeName":"Tsutomu","Initials":"T","AffiliationInfo":[{"Affiliation":"Laboratory for Vertebrate Axis Formation, Center for Developmental Biology, RIKEN, Kobe 650-0047, Japan."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Nakazawa","ForeName":"Masato","Initials":"M"},{"@attributes":{"ValidYN":"Y"},"LastName":"Yoshihara","ForeName":"Sei-ichi","Initials":"S"},{"@attributes":{"ValidYN":"Y"},"LastName":"Miyachi","ForeName":"Hitoshi","Initials":"H"},{"@attributes":{"ValidYN":"Y"},"LastName":"Kitamura","ForeName":"Kunio","Initials":"K"},{"@attributes":{"ValidYN":"Y"},"LastName":"Yoshihara","ForeName":"Yoshihiro","Initials":"Y"},{"@attributes":{"ValidYN":"Y"},"LastName":"Hibi","ForeName":"Masahiko","Initials":"M"}]},"Language":["eng"],"DataBankList":{"@attributes":{"CompleteYN":"Y"},"DataBank":[{"DataBankName":"GENBANK","AccessionNumberList":{"AccessionNumber":["AB207804","AK014242"]}}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D013485"},"@text":"Research Support, Non-U.S. Gov't"}]},"ArticleDate":[{"@attributes":{"DateType":"Electronic"},"Year":"2006","Month":"03","Day":"15"}]},"MedlineJournalInfo":{"Country":"England","MedlineTA":"Development","NlmUniqueID":"8701744","ISSNLinking":"0950-1991"},"ChemicalList":{"Chemical":[{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D004268"},"@text":"DNA-Binding Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D009419"},"@text":"Nerve Tissue Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C412364"},"@text":"Zfp312 protein, mouse"}}]},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D001370","MajorTopicYN":"N"},"@text":"Axonal Transport"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D002454","MajorTopicYN":"N"},"@text":"Cell Differentiation"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D002465","MajorTopicYN":"N"},"@text":"Cell Movement"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D003433","MajorTopicYN":"N"},"@text":"Crosses, Genetic"}},{"DescriptorName":{"@attributes":{"UI":"D004268","MajorTopicYN":"N"},"@text":"DNA-Binding Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000096","MajorTopicYN":"N"},"@text":"biosynthesis"},{"@attributes":{"UI":"Q000172","MajorTopicYN":"N"},"@text":"deficiency"},{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"},{"@attributes":{"UI":"Q000502","MajorTopicYN":"N"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D005260","MajorTopicYN":"N"},"@text":"Female"}},{"DescriptorName":{"@attributes":{"UI":"D007395","MajorTopicYN":"N"},"@text":"Interneurons"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"N"},"@text":"cytology"}]},{"DescriptorName":{"@attributes":{"UI":"D008297","MajorTopicYN":"N"},"@text":"Male"}},{"DescriptorName":{"@attributes":{"UI":"D051379","MajorTopicYN":"N"},"@text":"Mice"}},{"DescriptorName":{"@attributes":{"UI":"D008810","MajorTopicYN":"N"},"@text":"Mice, Inbred C57BL"}},{"DescriptorName":{"@attributes":{"UI":"D018345","MajorTopicYN":"N"},"@text":"Mice, Knockout"}},{"DescriptorName":{"@attributes":{"UI":"D008822","MajorTopicYN":"N"},"@text":"Mice, Transgenic"}},{"DescriptorName":{"@attributes":{"UI":"D008969","MajorTopicYN":"N"},"@text":"Molecular Sequence Data"}},{"DescriptorName":{"@attributes":{"UI":"D009419","MajorTopicYN":"N"},"@text":"Nerve Tissue Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000096","MajorTopicYN":"N"},"@text":"biosynthesis"},{"@attributes":{"UI":"Q000172","MajorTopicYN":"N"},"@text":"deficiency"},{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"},{"@attributes":{"UI":"Q000502","MajorTopicYN":"N"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D009475","MajorTopicYN":"N"},"@text":"Neurons, Afferent"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"N"},"@text":"cytology"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"},{"@attributes":{"UI":"Q000502","MajorTopicYN":"Y"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D009830","MajorTopicYN":"N"},"@text":"Olfactory Bulb"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"N"},"@text":"cytology"},{"@attributes":{"UI":"Q000196","MajorTopicYN":"Y"},"@text":"embryology"}]},{"DescriptorName":{"@attributes":{"UI":"D015398","MajorTopicYN":"N"},"@text":"Signal Transduction"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D013234","MajorTopicYN":"N"},"@text":"Stem Cells"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D016335","MajorTopicYN":"N"},"@text":"Zinc Fingers"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"}]}]}},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"pubmed"},"Year":"2006","Month":"3","Day":"17","Hour":"9","Minute":"0"},{"@attributes":{"PubStatus":"medline"},"Year":"2006","Month":"6","Day":"14","Hour":"9","Minute":"0"},{"@attributes":{"PubStatus":"entrez"},"Year":"2006","Month":"3","Day":"17","Hour":"9","Minute":"0"}]},"PublicationStatus":"ppublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"16540508"},{"@attributes":{"IdType":"doi"},"@text":"10.1242\/dev.02329"},{"@attributes":{"IdType":"pii"},"@text":"dev.02329"}]}}}}