{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"18509036"},"DateCompleted":{"Year":"2008","Month":"07","Day":"01"},"DateRevised":{"Year":"2025","Month":"05","Day":"29"},"Article":{"@attributes":{"PubModel":"Print"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Electronic"},"@text":"1529-2401"},"JournalIssue":{"@attributes":{"CitedMedium":"Internet"},"Volume":"28","Issue":"22","PubDate":{"Year":"2008","Month":"May","Day":"28"}},"Title":"The Journal of neuroscience : the official journal of the Society for Neuroscience","ISOAbbreviation":"J Neurosci"},"ArticleTitle":"The glutamate receptor-interacting protein family of GluR2-binding proteins is required for long-term synaptic depression expression in cerebellar Purkinje cells.","Pagination":{"StartPage":"5752","EndPage":"5755","MedlinePgn":"5752-5"},"ELocationID":[{"@attributes":{"EIdType":"doi","ValidYN":"Y"},"@text":"10.1523\/JNEUROSCI.0654-08.2008"}],"Abstract":{"AbstractText":["Glutamate receptor-interacting protein 1 (GRIP1) and GRIP2 are closely related proteins that bind GluR2-containing AMPA receptors and couple them to structural and signaling complexes in neurons. Cerebellar long-term synaptic depression (LTD) is a model system of synaptic plasticity that is expressed by persistent internalization of GluR2-containing AMPA receptors. Here, we show that genetic deletion of both GRIP1 and GRIP2 blocks LTD expression in primary cultures of mouse cerebellar neurons but that single deletion of either isoform allows LTD to occur. In GRIP1\/2 double knock-out Purkinje cells, LTD can be fully rescued by a plasmid-driving expression of GRIP1 and partially rescued by a GRIP2 plasmid. These results indicate that the GRIP family comprises an essential molecular component for cerebellar LTD."]},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Takamiya","ForeName":"Kogo","Initials":"K","AffiliationInfo":[{"Affiliation":"Department of Neurosurgery, The Johns Hopkins University School of Medicine, Baltimore, Maryland 21205, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Mao","ForeName":"Lifang","Initials":"L"},{"@attributes":{"ValidYN":"Y"},"LastName":"Huganir","ForeName":"Richard L","Initials":"RL"},{"@attributes":{"ValidYN":"Y"},"LastName":"Linden","ForeName":"David J","Initials":"DJ"}]},"Language":["eng"],"GrantList":{"@attributes":{"CompleteYN":"Y"},"Grant":[{"GrantID":"R01 NS036715","Acronym":"NS","Agency":"NINDS NIH HHS","Country":"United States"},{"GrantID":"R37 MH051106","Acronym":"MH","Agency":"NIMH NIH HHS","Country":"United States"},{"GrantID":"P50 MH068830","Acronym":"MH","Agency":"NIMH NIH HHS","Country":"United States"},{"Acronym":"HHMI","Agency":"Howard Hughes Medical Institute","Country":"United States"},{"GrantID":"R37 MH51106","Acronym":"MH","Agency":"NIMH NIH HHS","Country":"United States"}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D052061"},"@text":"Research Support, N.I.H., Extramural"},{"@attributes":{"UI":"D013485"},"@text":"Research Support, Non-U.S. Gov't"}]}},"MedlineJournalInfo":{"Country":"United States","MedlineTA":"J Neurosci","NlmUniqueID":"8102140","ISSNLinking":"0270-6474"},"ChemicalList":{"Chemical":[{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D048868"},"@text":"Adaptor Proteins, Signal Transducing"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D002352"},"@text":"Carrier Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D018690"},"@text":"Excitatory Amino Acid Agonists"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C491309"},"@text":"Grip1 protein, mouse"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C485567"},"@text":"Grip2 protein, mouse"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D047908"},"@text":"Intracellular Signaling Peptides and Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D009419"},"@text":"Nerve Tissue Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C485184"},"@text":"enhanced green fluorescent protein"}},{"RegistryNumber":"147336-22-9","NameOfSubstance":{"@attributes":{"UI":"D049452"},"@text":"Green Fluorescent Proteins"}},{"RegistryNumber":"3KX376GY7L","NameOfSubstance":{"@attributes":{"UI":"D018698"},"@text":"Glutamic Acid"}},{"RegistryNumber":"534-82-7","NameOfSubstance":{"@attributes":{"UI":"D008734"},"@text":"Methoxyhydroxyphenylglycol"}},{"RegistryNumber":"UEH9K539KJ","NameOfSubstance":{"@attributes":{"UI":"C010117"},"@text":"3,4-dihydroxyphenylglycol"}}]},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D048868","MajorTopicYN":"N"},"@text":"Adaptor Proteins, Signal Transducing"},"QualifierName":[{"@attributes":{"UI":"Q000172","MajorTopicYN":"N"},"@text":"deficiency"},{"@attributes":{"UI":"Q000502","MajorTopicYN":"Y"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D002352","MajorTopicYN":"N"},"@text":"Carrier Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"Y"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D002478","MajorTopicYN":"N"},"@text":"Cells, Cultured"}},{"DescriptorName":{"@attributes":{"UI":"D002531","MajorTopicYN":"N"},"@text":"Cerebellum"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"Y"},"@text":"cytology"}]},{"DescriptorName":{"@attributes":{"UI":"D004558","MajorTopicYN":"N"},"@text":"Electric Stimulation"},"QualifierName":[{"@attributes":{"UI":"Q000379","MajorTopicYN":"N"},"@text":"methods"}]},{"DescriptorName":{"@attributes":{"UI":"D004622","MajorTopicYN":"N"},"@text":"Embryo, Mammalian"}},{"DescriptorName":{"@attributes":{"UI":"D018690","MajorTopicYN":"N"},"@text":"Excitatory Amino Acid Agonists"},"QualifierName":[{"@attributes":{"UI":"Q000494","MajorTopicYN":"N"},"@text":"pharmacology"}]},{"DescriptorName":{"@attributes":{"UI":"D018698","MajorTopicYN":"N"},"@text":"Glutamic Acid"},"QualifierName":[{"@attributes":{"UI":"Q000494","MajorTopicYN":"N"},"@text":"pharmacology"}]},{"DescriptorName":{"@attributes":{"UI":"D049452","MajorTopicYN":"N"},"@text":"Green Fluorescent 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Domains"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"N"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D018408","MajorTopicYN":"N"},"@text":"Patch-Clamp Techniques"},"QualifierName":[{"@attributes":{"UI":"Q000379","MajorTopicYN":"N"},"@text":"methods"}]},{"DescriptorName":{"@attributes":{"UI":"D011689","MajorTopicYN":"N"},"@text":"Purkinje Cells"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"Y"},"@text":"physiology"}]}]}},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"pubmed"},"Year":"2008","Month":"5","Day":"30","Hour":"9","Minute":"0"},{"@attributes":{"PubStatus":"medline"},"Year":"2008","Month":"7","Day":"2","Hour":"9","Minute":"0"},{"@attributes":{"PubStatus":"entrez"},"Year":"2008","Month":"5","Day":"30","Hour":"9","Minute":"0"},{"@attributes":{"PubStatus":"pmc-release"},"Year":"2008","Month":"11","Day":"28"}]},"PublicationStatus":"ppublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"18509036"},{"@attributes":{"IdType":"mid"},"@text":"NIHMS56925"},{"@attributes":{"IdType":"pmc"},"@text":"PMC2587083"},{"@attributes":{"IdType":"doi"},"@text":"10.1523\/JNEUROSCI.0654-08.2008"},{"@attributes":{"IdType":"pii"},"@text":"28\/22\/5752"}]},"ReferenceList":[{"Reference":[{"Citation":"Bladt F, Tafuri A, Gelkop S, Langille L, Pawson T. 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