{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"20392907"},"DateCompleted":{"Year":"2010","Month":"09","Day":"14"},"DateRevised":{"Year":"2021","Month":"10","Day":"20"},"Article":{"@attributes":{"PubModel":"Print-Electronic"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Electronic"},"@text":"1098-660X"},"JournalIssue":{"@attributes":{"CitedMedium":"Internet"},"Volume":"48","Issue":"6","PubDate":{"Year":"2010","Month":"Jun"}},"Title":"Journal of clinical microbiology","ISOAbbreviation":"J Clin Microbiol"},"ArticleTitle":"CagA and VacA polymorphisms are associated with distinct pathological features in Helicobacter pylori-infected adults with peptic ulcer and non-peptic ulcer disease.","Pagination":{"StartPage":"2237","EndPage":"2239","MedlinePgn":"2237-9"},"ELocationID":[{"@attributes":{"EIdType":"doi","ValidYN":"Y"},"@text":"10.1128\/JCM.00662-10"}],"Abstract":{"AbstractText":["Polymorphic variability in Helicobacter pylori factors CagA and VacA contributes to bacterial virulence. The presence of one CagA EPIYA-C site is an independent risk factor for gastroduodenal ulceration (odds ratio [OR], 4.647; 95% confidence interval [CI], 2.037 to 10.602), while the presence of the vacA i1 allele is a risk factor for increased activity (OR, 5.310; 95% CI, 2.295 to 12.287) and severity of gastritis (OR, 3.862; 95% CI, 1.728 to 8.632)."]},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Panayotopoulou","ForeName":"Effrosini G","Initials":"EG","AffiliationInfo":[{"Affiliation":"Laboratory of Medical Microbiology, Hellenic Pasteur Institute, Athens, Greece."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Sgouras","ForeName":"Dionyssios N","Initials":"DN"},{"@attributes":{"ValidYN":"Y"},"LastName":"Papadakos","ForeName":"Konstantinos S","Initials":"KS"},{"@attributes":{"ValidYN":"Y"},"LastName":"Petraki","ForeName":"Kalliopi","Initials":"K"},{"@attributes":{"ValidYN":"Y"},"LastName":"Breurec","ForeName":"S\u00e9bastien","Initials":"S"},{"@attributes":{"ValidYN":"Y"},"LastName":"Michopoulos","ForeName":"Spyros","Initials":"S"},{"@attributes":{"ValidYN":"Y"},"LastName":"Mantzaris","ForeName":"Gerassimos","Initials":"G"},{"@attributes":{"ValidYN":"Y"},"LastName":"Papatheodoridis","ForeName":"George","Initials":"G"},{"@attributes":{"ValidYN":"Y"},"LastName":"Mentis","ForeName":"Andreas","Initials":"A"},{"@attributes":{"ValidYN":"Y"},"LastName":"Archimandritis","ForeName":"Athanasios","Initials":"A"}]},"Language":["eng"],"DataBankList":{"@attributes":{"CompleteYN":"Y"},"DataBank":[{"DataBankName":"GENBANK","AccessionNumberList":{"AccessionNumber":["FN561978","FN561979","FN561980","FN561981","FN561982","FN561983","FN561984","FN561985","FN561986","FN561987","FN561988","FN561989","FN561990","FN561991","FN561992","FN561993","FN561994","FN561995","FN561996","FN561997","FN561998","FN561999","FN562000","FN562001","FN562002","FN562003","FN562004","FN562005","FN562006","FN562007","FN562008","FN562009","FN562010","FN562011","FN562012","FN562013","FN562014","FN562015","FN562016","FN562017","FN562018","FN562019","FN562020","FN562021","FN562022","FN562023","FN562024","FN562025"]}}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal 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pylori"}}]},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D000328","MajorTopicYN":"N"},"@text":"Adult"}},{"DescriptorName":{"@attributes":{"UI":"D000368","MajorTopicYN":"N"},"@text":"Aged"}},{"DescriptorName":{"@attributes":{"UI":"D000942","MajorTopicYN":"N"},"@text":"Antigens, Bacterial"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D001426","MajorTopicYN":"N"},"@text":"Bacterial Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D004269","MajorTopicYN":"N"},"@text":"DNA, Bacterial"},"QualifierName":[{"@attributes":{"UI":"Q000737","MajorTopicYN":"N"},"@text":"chemistry"},{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D005260","MajorTopicYN":"N"},"@text":"Female"}},{"DescriptorName":{"@attributes":{"UI":"D016481","MajorTopicYN":"N"},"@text":"Helicobacter Infections"},"QualifierName":[{"@attributes":{"UI":"Q000382","MajorTopicYN":"N"},"@text":"microbiology"},{"@attributes":{"UI":"Q000473","MajorTopicYN":"Y"},"@text":"pathology"}]},{"DescriptorName":{"@attributes":{"UI":"D016480","MajorTopicYN":"N"},"@text":"Helicobacter pylori"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"},{"@attributes":{"UI":"Q000302","MajorTopicYN":"N"},"@text":"isolation & purification"},{"@attributes":{"UI":"Q000472","MajorTopicYN":"N"},"@text":"pathogenicity"}]},{"DescriptorName":{"@attributes":{"UI":"D006801","MajorTopicYN":"N"},"@text":"Humans"}},{"DescriptorName":{"@attributes":{"UI":"D008297","MajorTopicYN":"N"},"@text":"Male"}},{"DescriptorName":{"@attributes":{"UI":"D008875","MajorTopicYN":"N"},"@text":"Middle Aged"}},{"DescriptorName":{"@attributes":{"UI":"D008969","MajorTopicYN":"N"},"@text":"Molecular Sequence Data"}},{"DescriptorName":{"@attributes":{"UI":"D010437","MajorTopicYN":"N"},"@text":"Peptic Ulcer"},"QualifierName":[{"@attributes":{"UI":"Q000382","MajorTopicYN":"N"},"@text":"microbiology"}]},{"DescriptorName":{"@attributes":{"UI":"D011110","MajorTopicYN":"Y"},"@text":"Polymorphism, Genetic"}},{"DescriptorName":{"@attributes":{"UI":"D017422","MajorTopicYN":"N"},"@text":"Sequence Analysis, DNA"}},{"DescriptorName":{"@attributes":{"UI":"D012720","MajorTopicYN":"N"},"@text":"Severity of Illness Index"}},{"DescriptorName":{"@attributes":{"UI":"D037521","MajorTopicYN":"N"},"@text":"Virulence Factors"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"}]}]}},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"entrez"},"Year":"2010","Month":"4","Day":"16","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"pubmed"},"Year":"2010","Month":"4","Day":"16","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"medline"},"Year":"2010","Month":"9","Day":"15","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"pmc-release"},"Year":"2010","Month":"12","Day":"1"}]},"PublicationStatus":"ppublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"20392907"},{"@attributes":{"IdType":"pmc"},"@text":"PMC2884518"},{"@attributes":{"IdType":"doi"},"@text":"10.1128\/JCM.00662-10"},{"@attributes":{"IdType":"pii"},"@text":"JCM.00662-10"}]},"ReferenceList":[{"Reference":[{"Citation":"<b>Argent, R. H., M. Kidd, R. J. Owen, R. J. Thomas, M. C. Limb, and J. C. Atherton.<\/b> 2004. Determinants and consequences of different levels of CagA phosphorylation for clinical isolates of Helicobacter pylori. Gastroenterology 127<b>:<\/b>514-523.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"15300584"}]}},{"Citation":"<b>Atherton, J. C.<\/b> 2006. The pathogenesis of Helicobacter pylori-induced gastro-duodenal diseases. Annu. Rev. Pathol. 1<b>:<\/b>63-96.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"18039108"}]}},{"Citation":"<b>Atherton, J. C., P. Cao, R. M. Peek, Jr., M. K. Tummuru, M. J. Blaser, and T. L. Cover.<\/b> 1995. Mosaicism in vacuolating cytotoxin alleles of Helicobacter pylori. Association of specific vacA types with cytotoxin production and peptic ulceration. J. Biol. Chem. 270<b>:<\/b>17771-17777.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"7629077"}]}},{"Citation":"<b>Azuma, T., S. Yamazaki, A. Yamakawa, M. Ohtani, A. Muramatsu, H. Suto, Y. Ito, M. Dojo, Y. Yamazaki, M. Kuriyama, Y. Keida, H. Higashi, and M. Hatakeyama.<\/b> 2004. Association between diversity in the Src homology 2 domain-containing tyrosine phosphatase binding site of Helicobacter pylori CagA protein and gastric atrophy and cancer. J. Infect. Dis. 189<b>:<\/b>820-827.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"14976598"}]}},{"Citation":"<b>Basso, D., C. F. Zambon, D. P. Letley, A. Stranges, A. Marchet, J. L. Rhead, S. Schiavon, G. Guariso, M. Ceroti, D. Nitti, M. Rugge, M. Plebani, and J. C. Atherton.<\/b> 2008. Clinical relevance of Helicobacter pylori cagA and vacA gene polymorphisms. Gastroenterology 135<b>:<\/b>91-99.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"18474244"}]}},{"Citation":"<b>Blaser, M. J., and J. C. Atherton.<\/b> 2004. Helicobacter pylori persistence: biology and disease. J. Clin. Invest. 113<b>:<\/b>321-333.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC324548"},{"@attributes":{"IdType":"pubmed"},"@text":"14755326"}]}},{"Citation":"<b>Cover, T. L., and S. R. Blanke.<\/b> 2005. Helicobacter pylori VacA, a paradigm for toxin multifunctionality. Nat. Rev. Microbiol. 3<b>:<\/b>320-332.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"15759043"}]}},{"Citation":"<b>Higashi, H., R. Tsutsumi, A. Fujita, S. Yamazaki, M. Asaka, T. Azuma, and M. Hatakeyama.<\/b> 2002. Biological activity of the Helicobacter pylori virulence factor CagA is determined by variation in the tyrosine phosphorylation sites. Proc. Natl. Acad. Sci. U. S. A. 99<b>:<\/b>14428-14433.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC137900"},{"@attributes":{"IdType":"pubmed"},"@text":"12391297"}]}},{"Citation":"<b>Jones, K. R., Y. M. Joo, S. Jang, Y. J. Yoo, H. S. Lee, I. S. Chung, C. H. Olsen, J. M. Whitmire, D. S. Merrell, and J. H. Cha.<\/b> 2009. Polymorphism in the CagA EPIYA motif impacts development of gastric cancer. J. Clin. Microbiol. 47<b>:<\/b>959-968.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC2668329"},{"@attributes":{"IdType":"pubmed"},"@text":"19158258"}]}},{"Citation":"<b>Naito, M., T. Yamazaki, R. Tsutsumi, H. Higashi, K. Onoe, S. Yamazaki, T. Azuma, and M. Hatakeyama.<\/b> 2006. Influence of EPIYA-repeat polymorphism on the phosphorylation-dependent biological activity of Helicobacter pylori CagA. Gastroenterology 130<b>:<\/b>1181-1190.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"16618412"}]}},{"Citation":"<b>Nogueira, C., C. Figueiredo, F. Carneiro, A. T. Gomes, R. Barreira, P. Figueira, C. Salgado, L. Belo, A. Peixoto, J. C. Bravo, L. E. Bravo, J. L. Realpe, A. P. Plaisier, W. G. Quint, B. Ruiz, P. Correa, and L. J. van Doorn.<\/b> 2001. Helicobacter pylori genotypes may determine gastric histopathology. Am. J. Pathol. 158<b>:<\/b>647-654.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC1850299"},{"@attributes":{"IdType":"pubmed"},"@text":"11159201"}]}},{"Citation":"<b>Nomura, A. M., G. I. Perez-Perez, J. Lee, G. Stemmermann, and M. J. Blaser.<\/b> 2002. Relation between Helicobacter pylori cagA status and risk of peptic ulcer disease. Am. J. Epidemiol. 155<b>:<\/b>1054-1059.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"12034584"}]}},{"Citation":"<b>Panayotopoulou, E. G., D. N. Sgouras, K. Papadakos, A. Kalliaropoulos, G. Papatheodoridis, A. F. Mentis, and A. J. Archimandritis.<\/b> 2007. Strategy to characterize the number and type of repeating EPIYA phosphorylation motifs in the carboxyl terminus of CagA protein in Helicobacter pylori clinical isolates. J. Clin. Microbiol. 45<b>:<\/b>488-495.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC1829008"},{"@attributes":{"IdType":"pubmed"},"@text":"17151214"}]}},{"Citation":"<b>Rhead, J. L., D. P. Letley, M. Mohammadi, N. Hussein, M. A. Mohagheghi, M. Eshagh Hosseini, and J. C. Atherton.<\/b> 2007. A new Helicobacter pylori vacuolating cytotoxin determinant, the intermediate region, is associated with gastric cancer. Gastroenterology 133<b>:<\/b>926-936.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"17854597"}]}},{"Citation":"<b>Sgouras, D. N., E. G. Panayotopoulou, K. Papadakos, B. Martinez-Gonzalez, A. Roumbani, J. Panayiotou, C. vanVliet-Constantinidou, A. F. Mentis, and E. Roma-Giannikou.<\/b> 2009. CagA and VacA polymorphisms do not correlate with severity of histopathological lesions in Helicobacter pylori-infected Greek children. J. Clin. Microbiol. 47<b>:<\/b>2426-2434.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC2725676"},{"@attributes":{"IdType":"pubmed"},"@text":"19535517"}]}},{"Citation":"<b>Soltermann, A., S. Koetzer, F. Eigenmann, and P. Komminoth.<\/b> 2007. Correlation of Helicobacter pylori virulence genotypes vacA and cagA with histological parameters of gastritis and patient's age. Mod. Pathol. 20<b>:<\/b>878-883.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"17541440"}]}},{"Citation":"<b>Van Doorn, L. J., C. Figueiredo, F. Megraud, S. Pena, P. Midolo, D. M. Queiroz, F. Carneiro, B. Vanderborght, M. D. Pegado, R. Sanna, W. De Boer, P. M. Schneeberger, P. Correa, E. K. Ng, J. Atherton, M. J. Blaser, and W. G. Quint.<\/b> 1999. Geographic distribution of vacA allelic types of Helicobacter pylori. Gastroenterology 116<b>:<\/b>823-830.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"10092304"}]}},{"Citation":"<b>van Doorn, L.-J., C. Figueiredo, R. Sanna, M. J. Blaser, and W. G. Quint.<\/b> 1999. Distinct variants of Helicobacter pylori cagA are associated with vacA subtypes. J. Clin. Microbiol. 37<b>:<\/b>2306-2311.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC85143"},{"@attributes":{"IdType":"pubmed"},"@text":"10364602"}]}},{"Citation":"<b>Yamaoka, Y., T. Kodama, O. Gutierrez, J. G. Kim, K. Kashima, and D. Y. Graham.<\/b> 1999. Relationship between Helicobacter pylori iceA, cagA, and vacA status and clinical outcome: studies in four different countries. J. Clin. Microbiol. 37<b>:<\/b>2274-2279.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC85136"},{"@attributes":{"IdType":"pubmed"},"@text":"10364597"}]}},{"Citation":"<b>Yamaoka, Y., T. Kodama, K. Kashima, D. Y. Graham, and A. R. Sepulveda.<\/b> 1998. Variants of the 3\u2032 region of the cagA gene in Helicobacter pylori isolates from patients with different H. pylori-associated diseases. J. Clin. Microbiol. 36<b>:<\/b>2258-2263.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC105028"},{"@attributes":{"IdType":"pubmed"},"@text":"9666002"}]}}]}]}}}