{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"20953195"},"DateCompleted":{"Year":"2010","Month":"11","Day":"12"},"DateRevised":{"Year":"2021","Month":"10","Day":"20"},"Article":{"@attributes":{"PubModel":"Print-Electronic"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Electronic"},"@text":"1546-1726"},"JournalIssue":{"@attributes":{"CitedMedium":"Internet"},"Volume":"13","Issue":"11","PubDate":{"Year":"2010","Month":"Nov"}},"Title":"Nature neuroscience","ISOAbbreviation":"Nat Neurosci"},"ArticleTitle":"Fezf2 directs the differentiation of corticofugal neurons from striatal progenitors in vivo.","Pagination":{"StartPage":"1345","EndPage":"1347","MedlinePgn":"1345-7"},"ELocationID":[{"@attributes":{"EIdType":"doi","ValidYN":"Y"},"@text":"10.1038\/nn.2658"}],"Abstract":{"AbstractText":["In the developing cerebral cortex, cell-extrinsic and cell-intrinsic signals govern the establishment of neuron subtype-specific identity. Here we show that, within the niche of the striatum, the expression of a single transcription factor, Fezf2, is sufficient to generate corticofugal neurons from progenitors fated to become medium spiny neurons. This demonstrates that a specific population of cortical projection neurons can be directed to differentiate outside of the cortex by cell-autonomous signaling."]},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Rouaux","ForeName":"Caroline","Initials":"C","AffiliationInfo":[{"Affiliation":"Center for Regenerative Medicine, Massachusetts General Hospital, Harvard Medical School, Boston, Massachusetts, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Arlotta","ForeName":"Paola","Initials":"P"}]},"Language":["eng"],"GrantList":{"@attributes":{"CompleteYN":"Y"},"Grant":[{"GrantID":"R01 NS062849","Acronym":"NS","Agency":"NINDS NIH HHS","Country":"United States"},{"GrantID":"NS062849","Acronym":"NS","Agency":"NINDS NIH HHS","Country":"United States"}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D052061"},"@text":"Research Support, N.I.H., Extramural"},{"@attributes":{"UI":"D013485"},"@text":"Research Support, Non-U.S. Gov't"}]},"ArticleDate":[{"@attributes":{"DateType":"Electronic"},"Year":"2010","Month":"10","Day":"17"}]},"MedlineJournalInfo":{"Country":"United States","MedlineTA":"Nat Neurosci","NlmUniqueID":"9809671","ISSNLinking":"1097-6256"},"ChemicalList":{"Chemical":[{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D004268"},"@text":"DNA-Binding Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D009419"},"@text":"Nerve Tissue Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D014157"},"@text":"Transcription Factors"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C412364"},"@text":"Zfp312 protein, mouse"}},{"RegistryNumber":"147336-22-9","NameOfSubstance":{"@attributes":{"UI":"D049452"},"@text":"Green Fluorescent Proteins"}}]},"CitationSubset":["IM"],"CommentsCorrectionsList":{"CommentsCorrections":[{"@attributes":{"RefType":"CommentIn"},"RefSource":"Nat Neurosci. 2010 Nov;13(11):1308-9. doi: 10.1038\/nn1110-1308.","PMID":{"@attributes":{"Version":"1"},"@text":"20975751"}}]},"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D002454","MajorTopicYN":"N"},"@text":"Cell Differentiation"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000502","MajorTopicYN":"Y"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D002540","MajorTopicYN":"N"},"@text":"Cerebral Cortex"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"Y"},"@text":"cytology"}]},{"DescriptorName":{"@attributes":{"UI":"D003342","MajorTopicYN":"N"},"@text":"Corpus Striatum"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"Y"},"@text":"cytology"}]},{"DescriptorName":{"@attributes":{"UI":"D004268","MajorTopicYN":"N"},"@text":"DNA-Binding Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D004622","MajorTopicYN":"N"},"@text":"Embryo, Mammalian"}},{"DescriptorName":{"@attributes":{"UI":"D053595","MajorTopicYN":"N"},"@text":"Embryonic Stem Cells"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"Y"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D018507","MajorTopicYN":"N"},"@text":"Gene Expression Regulation, Developmental"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000502","MajorTopicYN":"Y"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D049452","MajorTopicYN":"N"},"@text":"Green Fluorescent Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D051379","MajorTopicYN":"N"},"@text":"Mice"}},{"DescriptorName":{"@attributes":{"UI":"D008822","MajorTopicYN":"N"},"@text":"Mice, Transgenic"}},{"DescriptorName":{"@attributes":{"UI":"D009419","MajorTopicYN":"N"},"@text":"Nerve Tissue Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D009474","MajorTopicYN":"N"},"@text":"Neurons"},"QualifierName":[{"@attributes":{"UI":"Q000145","MajorTopicYN":"N"},"@text":"classification"},{"@attributes":{"UI":"Q000502","MajorTopicYN":"Y"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D014157","MajorTopicYN":"N"},"@text":"Transcription Factors"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]}]},"CoiStatement":"<b>COMPETING FINANCIAL INTERESTS<\/b>. The authors declare no competing financial interests."},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"received"},"Year":"2010","Month":"7","Day":"9"},{"@attributes":{"PubStatus":"accepted"},"Year":"2010","Month":"8","Day":"23"},{"@attributes":{"PubStatus":"entrez"},"Year":"2010","Month":"10","Day":"19","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"pubmed"},"Year":"2010","Month":"10","Day":"19","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"medline"},"Year":"2010","Month":"11","Day":"13","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"pmc-release"},"Year":"2014","Month":"10","Day":"23"}]},"PublicationStatus":"ppublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"20953195"},{"@attributes":{"IdType":"mid"},"@text":"NIHMS634541"},{"@attributes":{"IdType":"pmc"},"@text":"PMC4207442"},{"@attributes":{"IdType":"doi"},"@text":"10.1038\/nn.2658"},{"@attributes":{"IdType":"pii"},"@text":"nn.2658"}]},"ReferenceList":[{"Reference":[{"Citation":"Molyneaux BJ, Arlotta P, Menezes JR, Macklis JD. 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