{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"PubMed-not-MEDLINE","Owner":"NLM"},"PMID":{"@attributes":{"Version":"1"},"@text":"24010020"},"DateCompleted":{"Year":"2013","Month":"09","Day":"06"},"DateRevised":{"Year":"2021","Month":"10","Day":"21"},"Article":{"@attributes":{"PubModel":"Electronic-eCollection"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Print"},"@text":"2167-8359"},"JournalIssue":{"@attributes":{"CitedMedium":"Print"},"Volume":"1","PubDate":{"Year":"2013"}},"Title":"PeerJ","ISOAbbreviation":"PeerJ"},"ArticleTitle":"The homeodomain factor Gbx1 is required for locomotion and cell specification in the dorsal spinal cord.","Pagination":{"StartPage":"e142","MedlinePgn":"e142"},"ELocationID":[{"@attributes":{"EIdType":"pii","ValidYN":"Y"},"@text":"e142"},{"@attributes":{"EIdType":"doi","ValidYN":"Y"},"@text":"10.7717\/peerj.142"}],"Abstract":{"AbstractText":["Dorsal horn neurons in the spinal cord integrate and relay sensory information to higher brain centers. These neurons are organized in specific laminae and different transcription factors are involved in their specification. The murine homeodomain Gbx1 protein is expressed in the mantle zone of the spinal cord at E12.5-13.5, correlating with the appearance of a discernable dorsal horn around E14 and eventually defining a narrow layer in the dorsal horn around perinatal stages. At postnatal stages, Gbx1 identifies a specific subpopulation of GABAergic neurons in the dorsal spinal cord. We have generated a loss of function mutation for Gbx1 and analyzed its consequences during spinal cord development. Gbx1 (-\/-) mice are viable and can reproduce as homozygous null mutants. However, the adult mutant mice display an altered gait during forward movement that specifically affects the hindlimbs. This abnormal gait was evaluated by a series of behavioral tests, indicating that locomotion is impaired, but not muscle strength or motor coordination. Molecular analysis showed that the development of the dorsal horn is not profoundly affected in Gbx1 (-\/-) mutant mice. However, analysis of terminal neuronal differentiation revealed that the proportion of GABAergic inhibitory interneurons in the superficial dorsal horn is diminished. Our study unveiled a role for Gbx1 in specifying a subset of GABAergic neurons in the dorsal horn of the spinal cord involved in the control of posterior limb movement."]},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y","EqualContrib":"Y"},"LastName":"Meziane","ForeName":"Hamid","Initials":"H","AffiliationInfo":[{"Affiliation":"Mouse Clinical Institute \/ Institut Clinique de la Souris, PHENOMIN, GIE CERBM, Illkirch Cedex, France."}]},{"@attributes":{"ValidYN":"Y","EqualContrib":"Y"},"LastName":"Fraulob","ForeName":"Val\u00e9rie","Initials":"V","AffiliationInfo":[{"Affiliation":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Universit\u00e9 de Strasbourg, Illkirch Cedex, France."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Riet","ForeName":"Fabrice","Initials":"F","AffiliationInfo":[{"Affiliation":"Mouse Clinical Institute \/ Institut Clinique de la Souris, PHENOMIN, GIE CERBM, Illkirch Cedex, France."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Krezel","ForeName":"Wojciech","Initials":"W","AffiliationInfo":[{"Affiliation":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Universit\u00e9 de Strasbourg, Illkirch Cedex, France."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Selloum","ForeName":"Mohammed","Initials":"M","AffiliationInfo":[{"Affiliation":"Mouse Clinical Institute \/ Institut Clinique de la Souris, PHENOMIN, GIE CERBM, Illkirch Cedex, France."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Geffarth","ForeName":"Michaela","Initials":"M","AffiliationInfo":[{"Affiliation":"DFG-Center for Regenerative Therapies \/ Cluster of Excellence, and Biotechnology Center, Technische Universit\u00e4t Dresden, Dresden, Germany."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Acampora","ForeName":"Dario","Initials":"D","AffiliationInfo":[{"Affiliation":"Institute of Genetics and Biophysics \"Adriano Buzzati-Traverso\", Naples, Italy."},{"Affiliation":"IRCCS Neuromed, Pozzilli, Italy."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"H\u00e9rault","ForeName":"Yann","Initials":"Y","AffiliationInfo":[{"Affiliation":"Mouse Clinical Institute \/ Institut Clinique de la Souris, PHENOMIN, GIE CERBM, Illkirch Cedex, France."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Simeone","ForeName":"Antonio","Initials":"A","AffiliationInfo":[{"Affiliation":"Institute of Genetics and Biophysics \"Adriano Buzzati-Traverso\", Naples, Italy."},{"Affiliation":"IRCCS Neuromed, Pozzilli, Italy."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Brand","ForeName":"Michael","Initials":"M","AffiliationInfo":[{"Affiliation":"DFG-Center for Regenerative Therapies \/ Cluster of Excellence, and Biotechnology Center, Technische Universit\u00e4t Dresden, Dresden, Germany."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Doll\u00e9","ForeName":"Pascal","Initials":"P","AffiliationInfo":[{"Affiliation":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Universit\u00e9 de Strasbourg, Illkirch Cedex, France."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Rhinn","ForeName":"Muriel","Initials":"M","AffiliationInfo":[{"Affiliation":"Institut de G\u00e9n\u00e9tique et de Biologie Mol\u00e9culaire et Cellulaire, Centre National de la Recherche Scientifique, Institut National de la Sant\u00e9 et de la Recherche M\u00e9dicale, Universit\u00e9 de Strasbourg, Illkirch Cedex, France."}]}]},"Language":["eng"],"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"}]},"ArticleDate":[{"@attributes":{"DateType":"Electronic"},"Year":"2013","Month":"08","Day":"29"}]},"MedlineJournalInfo":{"Country":"United States","MedlineTA":"PeerJ","NlmUniqueID":"101603425","ISSNLinking":"2167-8359"},"KeywordList":[{"@attributes":{"Owner":"NOTNLM"},"Keyword":[{"@attributes":{"MajorTopicYN":"N"},"@text":"GABAergic neurons"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Gbx genes"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Locomotion"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Mouse mutant"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Spinal cord"}]}]},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"received"},"Year":"2012","Month":"11","Day":"27"},{"@attributes":{"PubStatus":"accepted"},"Year":"2013","Month":"8","Day":"4"},{"@attributes":{"PubStatus":"entrez"},"Year":"2013","Month":"9","Day":"7","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"pubmed"},"Year":"2013","Month":"9","Day":"7","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"medline"},"Year":"2013","Month":"9","Day":"7","Hour":"6","Minute":"1"},{"@attributes":{"PubStatus":"pmc-release"},"Year":"2013","Month":"8","Day":"29"}]},"PublicationStatus":"epublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"24010020"},{"@attributes":{"IdType":"pmc"},"@text":"PMC3757465"},{"@attributes":{"IdType":"doi"},"@text":"10.7717\/peerj.142"},{"@attributes":{"IdType":"pii"},"@text":"142"}]},"ReferenceList":[{"Reference":[{"Citation":"Bellocchio EE, Reimer RJ, Fremeau RT, Edwards RH. 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