{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"24913420"},"DateCompleted":{"Year":"2015","Month":"04","Day":"07"},"DateRevised":{"Year":"2021","Month":"10","Day":"21"},"Article":{"@attributes":{"PubModel":"Print-Electronic"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Electronic"},"@text":"1521-1878"},"JournalIssue":{"@attributes":{"CitedMedium":"Internet"},"Volume":"36","Issue":"8","PubDate":{"Year":"2014","Month":"Aug"}},"Title":"BioEssays : news and reviews in molecular, cellular and developmental biology","ISOAbbreviation":"Bioessays"},"ArticleTitle":"Fez family transcription factors: controlling neurogenesis and cell fate in the developing mammalian nervous system.","Pagination":{"StartPage":"788","EndPage":"797","MedlinePgn":"788-97"},"ELocationID":[{"@attributes":{"EIdType":"doi","ValidYN":"Y"},"@text":"10.1002\/bies.201400039"}],"Abstract":{"AbstractText":["Fezf1 and Fezf2 are highly conserved transcription factors that were first identified by their specific expression in the anterior neuroepithelium of Xenopus and zebrafish embryos. These proteins share an N-terminal domain with homology to the canonical engrailed repressor motif and a C-terminal DNA binding domain containing six C2H2 zinc-finger repeats. Over a decade of study indicates that the Fez proteins play critical roles during nervous system development in species as diverse as fruit flies and mice. Herein we discuss recent progress in understanding the functions of Fezf1 and Fezf2 in neurogenesis and cell fate specification during mammalian nervous system development. Going forward we believe that efforts should focus on understanding how expression of these factors is precisely regulated, and on identifying target DNA sequences and interacting partners. Such knowledge may reveal the mechanisms by which Fezf1 and Fezf2 accomplish both independent and redundant functions across diverse tissue and cell types."],"CopyrightInformation":"\u00a9 2014 WILEY Periodicals, Inc."},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Eckler","ForeName":"Matthew J","Initials":"MJ","AffiliationInfo":[{"Affiliation":"Department of Molecular, Cell and Developmental Biology, University of California, Santa Cruz, CA, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Chen","ForeName":"Bin","Initials":"B"}]},"Language":["eng"],"GrantList":{"@attributes":{"CompleteYN":"Y"},"Grant":[{"GrantID":"R01 MH094589","Acronym":"MH","Agency":"NIMH NIH HHS","Country":"United States"},{"GrantID":"R01-MH094589","Acronym":"MH","Agency":"NIMH NIH HHS","Country":"United States"}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D052061"},"@text":"Research Support, N.I.H., Extramural"},{"@attributes":{"UI":"D013485"},"@text":"Research Support, Non-U.S. Gov't"},{"@attributes":{"UI":"D016454"},"@text":"Review"}]},"ArticleDate":[{"@attributes":{"DateType":"Electronic"},"Year":"2014","Month":"06","Day":"10"}]},"MedlineJournalInfo":{"Country":"United States","MedlineTA":"Bioessays","NlmUniqueID":"8510851","ISSNLinking":"0265-9247"},"ChemicalList":{"Chemical":[{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C000595492"},"@text":"FEZF1 protein, human"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C557090"},"@text":"FEZF2 protein, human"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D012097"},"@text":"Repressor Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D014157"},"@text":"Transcription Factors"}}]},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D019521","MajorTopicYN":"N"},"@text":"Body Patterning"}},{"DescriptorName":{"@attributes":{"UI":"D019143","MajorTopicYN":"N"},"@text":"Evolution, Molecular"}},{"DescriptorName":{"@attributes":{"UI":"D018507","MajorTopicYN":"N"},"@text":"Gene Expression Regulation, Developmental"}},{"DescriptorName":{"@attributes":{"UI":"D006801","MajorTopicYN":"N"},"@text":"Humans"}},{"DescriptorName":{"@attributes":{"UI":"D058953","MajorTopicYN":"N"},"@text":"Neural Stem Cells"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"N"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D055495","MajorTopicYN":"Y"},"@text":"Neurogenesis"}},{"DescriptorName":{"@attributes":{"UI":"D066194","MajorTopicYN":"N"},"@text":"Olfactory Cortex"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"N"},"@text":"cytology"},{"@attributes":{"UI":"Q000196","MajorTopicYN":"Y"},"@text":"embryology"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D016548","MajorTopicYN":"N"},"@text":"Prosencephalon"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"N"},"@text":"cytology"},{"@attributes":{"UI":"Q000196","MajorTopicYN":"Y"},"@text":"embryology"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D012097","MajorTopicYN":"N"},"@text":"Repressor Proteins"}},{"DescriptorName":{"@attributes":{"UI":"D014157","MajorTopicYN":"N"},"@text":"Transcription Factors"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"Y"},"@text":"physiology"}]}]},"KeywordList":[{"@attributes":{"Owner":"NOTNLM"},"Keyword":[{"@attributes":{"MajorTopicYN":"N"},"@text":"Fezf1"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Fezf2"},{"@attributes":{"MajorTopicYN":"N"},"@text":"cell fate"},{"@attributes":{"MajorTopicYN":"N"},"@text":"cerebral cortex"},{"@attributes":{"MajorTopicYN":"N"},"@text":"gene expression"},{"@attributes":{"MajorTopicYN":"N"},"@text":"neurogenesis"},{"@attributes":{"MajorTopicYN":"N"},"@text":"olfactory system"}]}]},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"entrez"},"Year":"2014","Month":"6","Day":"11","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"pubmed"},"Year":"2014","Month":"6","Day":"11","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"medline"},"Year":"2015","Month":"4","Day":"8","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"pmc-release"},"Year":"2017","Month":"6","Day":"15"}]},"PublicationStatus":"ppublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"24913420"},{"@attributes":{"IdType":"mid"},"@text":"NIHMS860478"},{"@attributes":{"IdType":"pmc"},"@text":"PMC5472476"},{"@attributes":{"IdType":"doi"},"@text":"10.1002\/bies.201400039"}]},"ReferenceList":[{"Reference":[{"Citation":"Shimizu T, Hibi M. 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