{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"25319688"},"DateCompleted":{"Year":"2015","Month":"02","Day":"06"},"DateRevised":{"Year":"2022","Month":"03","Day":"18"},"Article":{"@attributes":{"PubModel":"Print"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Electronic"},"@text":"1529-2401"},"JournalIssue":{"@attributes":{"CitedMedium":"Internet"},"Volume":"34","Issue":"42","PubDate":{"Year":"2014","Month":"Oct","Day":"15"}},"Title":"The Journal of neuroscience : the official journal of the Society for Neuroscience","ISOAbbreviation":"J Neurosci"},"ArticleTitle":"Heterogeneously expressed fezf2 patterns gradient Notch activity in balancing the quiescence, proliferation, and differentiation of adult neural stem cells.","Pagination":{"StartPage":"13911","EndPage":"13923","MedlinePgn":"13911-23"},"ELocationID":[{"@attributes":{"EIdType":"doi","ValidYN":"Y"},"@text":"10.1523\/JNEUROSCI.1976-14.2014"}],"Abstract":{"AbstractText":["Balancing quiescence, self-renewal, and differentiation in adult stem cells is critical for tissue homeostasis. The underlying mechanisms, however, remain incompletely understood. Here we identify Fezf2 as a novel regulator of fate balance in adult zebrafish dorsal telencephalic neural stem cells (NSCs). Transgenic reporters show intermingled fezf2-GFP(hi) quiescent and fezf2-GFP(lo) proliferative NSCs. Constitutive or conditional impairment of fezf2 activity demonstrates its requirement for maintaining quiescence. Analyses of genetic chimeras reveal a dose-dependent role of fezf2 in NSC activation, suggesting that the difference in fezf2 levels directionally biases fate. Single NSC profiling coupled with genetic analysis further uncovers a fezf2-dependent gradient Notch activity that is high in quiescent and low in proliferative NSCs. Finally, fezf2-GFP(hi) quiescent and fezf2-GFP(lo) proliferative NSCs are observed in postnatal mouse hippocampus, suggesting possible evolutionary conservation. Our results support a model in which fezf2 heterogeneity patterns gradient Notch activity among neighbors that is critical to balance NSC fate."],"CopyrightInformation":"Copyright \u00a9 2014 the authors 0270-6474\/14\/3413911-13$15.00\/0."},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Berberoglu","ForeName":"Michael A","Initials":"MA","AffiliationInfo":[{"Affiliation":"Department of Bioengineering and Therapeutic Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Graduate Program in Neuroscience, Institute of Human Genetics, Department of Molecular Genetics, Ohio State University, Columbus, Ohio 43210."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Dong","ForeName":"Zhiqiang","Initials":"Z","Identifier":[{"@attributes":{"Source":"ORCID"},"@text":"0000-0001-6259-915X"}],"AffiliationInfo":[{"Affiliation":"Department of Bioengineering and Therapeutic Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Institute of Human Genetics."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Li","ForeName":"Guangnan","Initials":"G","AffiliationInfo":[{"Affiliation":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Department of Neurology."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Zheng","ForeName":"Jiashun","Initials":"J","AffiliationInfo":[{"Affiliation":"Department of Biochemistry and Biophysics."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Trejo Martinez","ForeName":"Luz del Carmen G","Initials":"Ldel C","AffiliationInfo":[{"Affiliation":"Department of Bioengineering and Therapeutic Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Institute of Human Genetics, Graduate Program in Cell and Molecular Biology, Department of Biology, San Francisco State University, San Francisco, California 94132."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Peng","ForeName":"Jisong","Initials":"J","AffiliationInfo":[{"Affiliation":"Department of Bioengineering and Therapeutic Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Institute of Human Genetics."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Wagle","ForeName":"Mahendra","Initials":"M","AffiliationInfo":[{"Affiliation":"Department of Bioengineering and Therapeutic Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Institute of Human Genetics."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Reichholf","ForeName":"Brian","Initials":"B","AffiliationInfo":[{"Affiliation":"Department of Neurological Surgery, and."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Petritsch","ForeName":"Claudia","Initials":"C","AffiliationInfo":[{"Affiliation":"Department of Neurological Surgery, and Brain Tumor Research Center, University of California, San Francisco, California 94143-2811."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Li","ForeName":"Hao","Initials":"H","AffiliationInfo":[{"Affiliation":"Department of Biochemistry and Biophysics."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Pleasure","ForeName":"Samuel J","Initials":"SJ","Identifier":[{"@attributes":{"Source":"ORCID"},"@text":"0000-0001-8599-1613"}],"AffiliationInfo":[{"Affiliation":"Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Graduate Program in Neuroscience, Department of Neurology."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Guo","ForeName":"Su","Initials":"S","Identifier":[{"@attributes":{"Source":"ORCID"},"@text":"0000-0002-7342-0108"}],"AffiliationInfo":[{"Affiliation":"Department of Bioengineering and Therapeutic Sciences, Eli and Edythe Broad Center of Regeneration Medicine and Stem Cell Research, Graduate Program in Neuroscience, Institute of Human Genetics, State Key Laboratory of Genetic Engineering and the Institute of Genetics, School of Life Sciences, Fudan University, Shanghai, China, and su.guo@ucsf.edu."}]}]},"Language":["eng"],"GrantList":{"@attributes":{"CompleteYN":"Y"},"Grant":[{"GrantID":"R01 NS080619","Acronym":"NS","Agency":"NINDS NIH HHS","Country":"United States"},{"GrantID":"R01 NS042626","Acronym":"NS","Agency":"NINDS NIH HHS","Country":"United States"},{"GrantID":"DA035680","Acronym":"DA","Agency":"NIDA NIH HHS","Country":"United States"},{"GrantID":"R01 CA164746","Acronym":"CA","Agency":"NCI NIH HHS","Country":"United States"},{"GrantID":"R01 MH077694","Acronym":"MH","Agency":"NIMH NIH HHS","Country":"United States"},{"GrantID":"NS042626","Acronym":"NS","Agency":"NINDS NIH HHS","Country":"United States"},{"GrantID":"R01 MH105360","Acronym":"MH","Agency":"NIMH NIH HHS","Country":"United States"},{"GrantID":"R01 DA035680","Acronym":"DA","Agency":"NIDA NIH HHS","Country":"United States"},{"GrantID":"T32 NS077984","Acronym":"NS","Agency":"NINDS NIH HHS","Country":"United States"}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D052061"},"@text":"Research Support, N.I.H., Extramural"}]}},"MedlineJournalInfo":{"Country":"United States","MedlineTA":"J Neurosci","NlmUniqueID":"8102140","ISSNLinking":"0270-6474"},"ChemicalList":{"Chemical":[{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D004268"},"@text":"DNA-Binding Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D009419"},"@text":"Nerve Tissue Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D051880"},"@text":"Receptors, Notch"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C412364"},"@text":"Zfp312 protein, mouse"}}]},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D053687","MajorTopicYN":"N"},"@text":"Adult Stem Cells"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D030801","MajorTopicYN":"N"},"@text":"Animals, Genetically Modified"}},{"DescriptorName":{"@attributes":{"UI":"D002454","MajorTopicYN":"N"},"@text":"Cell Differentiation"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"Y"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D049109","MajorTopicYN":"N"},"@text":"Cell Proliferation"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"Y"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D004268","MajorTopicYN":"N"},"@text":"DNA-Binding Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000096","MajorTopicYN":"Y"},"@text":"biosynthesis"}]},{"DescriptorName":{"@attributes":{"UI":"D005260","MajorTopicYN":"N"},"@text":"Female"}},{"DescriptorName":{"@attributes":{"UI":"D018507","MajorTopicYN":"N"},"@text":"Gene Expression Regulation, Developmental"}},{"DescriptorName":{"@attributes":{"UI":"D008297","MajorTopicYN":"N"},"@text":"Male"}},{"DescriptorName":{"@attributes":{"UI":"D051379","MajorTopicYN":"N"},"@text":"Mice"}},{"DescriptorName":{"@attributes":{"UI":"D008822","MajorTopicYN":"N"},"@text":"Mice, Transgenic"}},{"DescriptorName":{"@attributes":{"UI":"D009419","MajorTopicYN":"N"},"@text":"Nerve Tissue Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000096","MajorTopicYN":"Y"},"@text":"biosynthesis"}]},{"DescriptorName":{"@attributes":{"UI":"D058953","MajorTopicYN":"N"},"@text":"Neural Stem Cells"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D055495","MajorTopicYN":"N"},"@text":"Neurogenesis"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"N"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D051880","MajorTopicYN":"N"},"@text":"Receptors, Notch"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D015027","MajorTopicYN":"N"},"@text":"Zebrafish"}}]},"KeywordList":[{"@attributes":{"Owner":"NOTNLM"},"Keyword":[{"@attributes":{"MajorTopicYN":"N"},"@text":"adult neurogenesis"},{"@attributes":{"MajorTopicYN":"N"},"@text":"hippocampus"},{"@attributes":{"MajorTopicYN":"N"},"@text":"radial glia"},{"@attributes":{"MajorTopicYN":"N"},"@text":"self-renewal"},{"@attributes":{"MajorTopicYN":"N"},"@text":"single-cell analysis"},{"@attributes":{"MajorTopicYN":"N"},"@text":"vivo morpholino"}]}]},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"entrez"},"Year":"2014","Month":"10","Day":"17","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"pubmed"},"Year":"2014","Month":"10","Day":"17","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"medline"},"Year":"2015","Month":"2","Day":"7","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"pmc-release"},"Year":"2015","Month":"4","Day":"15"}]},"PublicationStatus":"ppublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"25319688"},{"@attributes":{"IdType":"pmc"},"@text":"PMC4198537"},{"@attributes":{"IdType":"doi"},"@text":"10.1523\/JNEUROSCI.1976-14.2014"},{"@attributes":{"IdType":"pii"},"@text":"34\/42\/13911"}]},"ReferenceList":[{"Reference":[{"Citation":"Adolf B, Chapouton P, Lam CS, Topp S, Tannh\u00e4user B, Str\u00e4hle U, G\u00f6tz M, Bally-Cuif L. 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