{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"26408707"},"DateCompleted":{"Year":"2016","Month":"01","Day":"04"},"DateRevised":{"Year":"2015","Month":"09","Day":"26"},"Article":{"@attributes":{"PubModel":"Print"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Electronic"},"@text":"1791-7530"},"JournalIssue":{"@attributes":{"CitedMedium":"Internet"},"Volume":"35","Issue":"10","PubDate":{"Year":"2015","Month":"Oct"}},"Title":"Anticancer research","ISOAbbreviation":"Anticancer Res"},"ArticleTitle":"Signatures of Adverse Pathological Features, Androgen Insensitivity and Metastatic Potential in Prostate Cancer.","Pagination":{"StartPage":"5443","EndPage":"5451","MedlinePgn":"5443-51"},"Abstract":{"AbstractText":[{"@attributes":{"Label":"BACKGROUND\/AIM","NlmCategory":"OBJECTIVE"},"@text":"The genetic characterization of prostate tumors is important for personalized therapy. The aim of the present study was to investigate the role of previously described prostate cancer-related genes in the genetic characterization of prostate tumors."},{"@attributes":{"Label":"MATERIALS AND METHODS","NlmCategory":"METHODS"},"@text":"Forty-two genes were selected for expression analysis (real time-quantitative polymerase chain reaction). One normal prostatic epithelial cell line and three standardized prostate cancer cell lines were used. Twenty-eight patients treated with radical prostatectomy were included in the study."},{"@attributes":{"Label":"RESULTS","NlmCategory":"RESULTS"},"@text":"The following genes appeared to be possibly related to the metastatic potential of the tumor: ELOVL fatty acid elongase 7 (ELOVL7), enhancer of zeste 2 polycomb repressive complex 2 subunit (EZH2), gastrulation brain homeobox 2 (GBX2), golgi membrane protein 1 (GOLM1), homeobox C6 (HOXC6), minichromosome maintenance complex component 6 (MCM6), marker of proliferation Ki-67 (MKI67), mucin 1, cell surface associated (MUC1), MYC binding protein 2, E3 ubiquitin protein ligase (MYCBP2), somatostatin receptor 1 (SSTR1), topoisomerase (DNA) II alpha 170 kDa (TOP2A) and exportin 6 (XPO6). Six genes were differentially expressed in patients with localized and locally advanced cancer (GOLM1, GBX2, XPO6, SSTR1, TOP2A and cell division cycle associated 5, CDCA5) and three genes (HOXC6, Cyclin-dependent kinase inhibitor 2A (CDKN2A) and MYC binding protein 2, E3 ubiquitin protein ligase, MYCBP2) in patients with a low vs. high Gleason grade\/sum."},{"@attributes":{"Label":"CONCLUSION","NlmCategory":"CONCLUSIONS"},"@text":"Some of the investigated genes show promising prognostic and classification features, which might be useful in a clinical setting, warranting for further validation."}],"CopyrightInformation":"Copyright\u00a9 2015 International Institute of Anticancer Research (Dr. John G. Delinassios), All rights reserved."},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Tolkach","ForeName":"Yuri","Initials":"Y","AffiliationInfo":[{"Affiliation":"Clinic for Urology and Urologic Oncology, Hannover Medical School, Hannover, Germany."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Merseburger","ForeName":"Axel","Initials":"A","AffiliationInfo":[{"Affiliation":"Clinic for Urology and Urologic Oncology, Hannover Medical School, Hannover, Germany."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Herrmann","ForeName":"Thomas","Initials":"T","AffiliationInfo":[{"Affiliation":"Clinic for Urology and Urologic Oncology, Hannover Medical School, Hannover, Germany."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Kuczyk","ForeName":"Markus","Initials":"M","AffiliationInfo":[{"Affiliation":"Clinic for Urology and Urologic Oncology, Hannover Medical School, Hannover, Germany."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Serth","ForeName":"J\u00fcrgen","Initials":"J","AffiliationInfo":[{"Affiliation":"Clinic for Urology and Urologic Oncology, Hannover Medical School, Hannover, Germany."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Imkamp","ForeName":"Florian","Initials":"F","AffiliationInfo":[{"Affiliation":"Clinic for Urology and Urologic Oncology, Hannover Medical School, Hannover, Germany imkamp.florian@mh-hannover.de."}]}]},"Language":["eng"],"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D013485"},"@text":"Research Support, Non-U.S. Gov't"}]}},"MedlineJournalInfo":{"Country":"Greece","MedlineTA":"Anticancer Res","NlmUniqueID":"8102988","ISSNLinking":"0250-7005"},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D000368","MajorTopicYN":"N"},"@text":"Aged"}},{"DescriptorName":{"@attributes":{"UI":"D045744","MajorTopicYN":"N"},"@text":"Cell Line, Tumor"}},{"DescriptorName":{"@attributes":{"UI":"D020869","MajorTopicYN":"N"},"@text":"Gene Expression Profiling"},"QualifierName":[{"@attributes":{"UI":"Q000379","MajorTopicYN":"N"},"@text":"methods"}]},{"DescriptorName":{"@attributes":{"UI":"D015972","MajorTopicYN":"Y"},"@text":"Gene Expression Regulation, Neoplastic"}},{"DescriptorName":{"@attributes":{"UI":"D006801","MajorTopicYN":"N"},"@text":"Humans"}},{"DescriptorName":{"@attributes":{"UI":"D008297","MajorTopicYN":"N"},"@text":"Male"}},{"DescriptorName":{"@attributes":{"UI":"D008875","MajorTopicYN":"N"},"@text":"Middle Aged"}},{"DescriptorName":{"@attributes":{"UI":"D060787","MajorTopicYN":"N"},"@text":"Neoplasm Grading"}},{"DescriptorName":{"@attributes":{"UI":"D009362","MajorTopicYN":"N"},"@text":"Neoplasm Metastasis"}},{"DescriptorName":{"@attributes":{"UI":"D010865","MajorTopicYN":"N"},"@text":"Pilot Projects"}},{"DescriptorName":{"@attributes":{"UI":"D011446","MajorTopicYN":"N"},"@text":"Prospective Studies"}},{"DescriptorName":{"@attributes":{"UI":"D011468","MajorTopicYN":"N"},"@text":"Prostatectomy"}},{"DescriptorName":{"@attributes":{"UI":"D011471","MajorTopicYN":"N"},"@text":"Prostatic Neoplasms"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"},{"@attributes":{"UI":"Q000473","MajorTopicYN":"Y"},"@text":"pathology"},{"@attributes":{"UI":"Q000601","MajorTopicYN":"N"},"@text":"surgery"}]}]},"KeywordList":[{"@attributes":{"Owner":"NOTNLM"},"Keyword":[{"@attributes":{"MajorTopicYN":"N"},"@text":"Prostate neoplasms"},{"@attributes":{"MajorTopicYN":"N"},"@text":"cell line"},{"@attributes":{"MajorTopicYN":"N"},"@text":"gene expression"},{"@attributes":{"MajorTopicYN":"N"},"@text":"radical prostatectomy"},{"@attributes":{"MajorTopicYN":"N"},"@text":"surgical pathology"}]}]},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"entrez"},"Year":"2015","Month":"9","Day":"27","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"pubmed"},"Year":"2015","Month":"9","Day":"27","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"medline"},"Year":"2016","Month":"1","Day":"5","Hour":"6","Minute":"0"}]},"PublicationStatus":"ppublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"26408707"},{"@attributes":{"IdType":"pii"},"@text":"35\/10\/5443"}]}}}}