{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"29513217"},"DateCompleted":{"Year":"2019","Month":"07","Day":"01"},"DateRevised":{"Year":"2020","Month":"03","Day":"06"},"Article":{"@attributes":{"PubModel":"Electronic"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Electronic"},"@text":"2050-084X"},"JournalIssue":{"@attributes":{"CitedMedium":"Internet"},"Volume":"7","PubDate":{"Year":"2018","Month":"Mar","Day":"07"}},"Title":"eLife","ISOAbbreviation":"Elife"},"ArticleTitle":"<i>Drosophila<\/i> Fezf coordinates laminar-specific connectivity through cell-intrinsic and cell-extrinsic mechanisms.","ELocationID":[{"@attributes":{"EIdType":"pii","ValidYN":"Y"},"@text":"e33962"},{"@attributes":{"EIdType":"doi","ValidYN":"Y"},"@text":"10.7554\/eLife.33962"}],"Abstract":{"AbstractText":["Laminar arrangement of neural connections is a fundamental feature of neural circuit organization. Identifying mechanisms that coordinate neural connections within correct layers is thus vital for understanding how neural circuits are assembled. In the medulla of the <i>Drosophila<\/i> visual system neurons form connections within ten parallel layers. The M3 layer receives input from two neuron types that sequentially innervate M3 during development. Here we show that M3-specific innervation by both neurons is coordinated by <i>Drosophila<\/i> Fezf (dFezf), a conserved transcription factor that is selectively expressed by the earlier targeting input neuron. In this cell, dFezf instructs layer specificity and activates the expression of a secreted molecule (Netrin) that regulates the layer specificity of the other input neuron. We propose that employment of transcriptional modules that cell-intrinsically target neurons to specific layers, and cell-extrinsically recruit other neurons is a general mechanism for building layered networks of neural connections."],"CopyrightInformation":"\u00a9 2018, Peng et al."},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y","EqualContrib":"Y"},"LastName":"Peng","ForeName":"Jing","Initials":"J","AffiliationInfo":[{"Affiliation":"Department of Neurobiology, Harvard Medical School, Boston, United States."}]},{"@attributes":{"ValidYN":"Y","EqualContrib":"Y"},"LastName":"Santiago","ForeName":"Ivan J","Initials":"IJ","AffiliationInfo":[{"Affiliation":"Department of Neurobiology, Harvard Medical School, Boston, United States."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Ahn","ForeName":"Curie","Initials":"C","AffiliationInfo":[{"Affiliation":"Department of Neurobiology, Harvard Medical School, Boston, United States."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Gur","ForeName":"Burak","Initials":"B","AffiliationInfo":[{"Affiliation":"European Neuroscience Institute, G\u00f6ttingen, Germany."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Tsui","ForeName":"C Kimberly","Initials":"CK","AffiliationInfo":[{"Affiliation":"Department of Genetics, Stanford University, Stanford, United States."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Su","ForeName":"Zhixiao","Initials":"Z","AffiliationInfo":[{"Affiliation":"Department of Neurobiology, Harvard Medical School, Boston, United States."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Xu","ForeName":"Chundi","Initials":"C","AffiliationInfo":[{"Affiliation":"Department of Neurobiology, Harvard Medical School, Boston, United States."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Karakhanyan","ForeName":"Aziz","Initials":"A","AffiliationInfo":[{"Affiliation":"Department of Neurobiology, Harvard Medical School, Boston, United States."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Silies","ForeName":"Marion","Initials":"M","AffiliationInfo":[{"Affiliation":"European Neuroscience Institute, G\u00f6ttingen, Germany."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Pecot","ForeName":"Matthew Y","Initials":"MY","Identifier":[{"@attributes":{"Source":"ORCID"},"@text":"0000-0001-8241-8002"}],"AffiliationInfo":[{"Affiliation":"Department of Neurobiology, Harvard Medical School, Boston, United States."}]}]},"Language":["eng"],"GrantList":{"@attributes":{"CompleteYN":"Y"},"Grant":[{"GrantID":"K01 NS094545","Acronym":"NS","Agency":"NINDS NIH HHS","Country":"United States"},{"GrantID":"Gilliam Fellowship for Advanced Study","Acronym":"HHMI","Agency":"Howard Hughes Medical Institute","Country":"United States"}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D013485"},"@text":"Research Support, Non-U.S. Gov't"}]},"ArticleDate":[{"@attributes":{"DateType":"Electronic"},"Year":"2018","Month":"03","Day":"07"}]},"MedlineJournalInfo":{"Country":"England","MedlineTA":"Elife","NlmUniqueID":"101579614","ISSNLinking":"2050-084X"},"ChemicalList":{"Chemical":[{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D029721"},"@text":"Drosophila Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D000075385"},"@text":"Netrins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D014157"},"@text":"Transcription Factors"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C547809"},"@text":"erm protein, Drosophila"}}]},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D029721","MajorTopicYN":"N"},"@text":"Drosophila Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D004331","MajorTopicYN":"N"},"@text":"Drosophila melanogaster"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000254","MajorTopicYN":"N"},"@text":"growth & development"}]},{"DescriptorName":{"@attributes":{"UI":"D018507","MajorTopicYN":"N"},"@text":"Gene Expression Regulation, Developmental"}},{"DescriptorName":{"@attributes":{"UI":"D008526","MajorTopicYN":"N"},"@text":"Medulla Oblongata"},"QualifierName":[{"@attributes":{"UI":"Q000254","MajorTopicYN":"N"},"@text":"growth & development"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D009415","MajorTopicYN":"N"},"@text":"Nerve Net"},"QualifierName":[{"@attributes":{"UI":"Q000254","MajorTopicYN":"N"},"@text":"growth & development"}]},{"DescriptorName":{"@attributes":{"UI":"D000075385","MajorTopicYN":"N"},"@text":"Netrins"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D055495","MajorTopicYN":"N"},"@text":"Neurogenesis"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D009474","MajorTopicYN":"N"},"@text":"Neurons"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D017956","MajorTopicYN":"N"},"@text":"Photoreceptor Cells, Invertebrate"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D013569","MajorTopicYN":"N"},"@text":"Synapses"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D014157","MajorTopicYN":"N"},"@text":"Transcription Factors"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D014795","MajorTopicYN":"N"},"@text":"Visual Pathways"},"QualifierName":[{"@attributes":{"UI":"Q000254","MajorTopicYN":"N"},"@text":"growth & development"}]}]},"KeywordList":[{"@attributes":{"Owner":"NOTNLM"},"Keyword":[{"@attributes":{"MajorTopicYN":"N"},"@text":"D. melanogaster"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Fezf"},{"@attributes":{"MajorTopicYN":"N"},"@text":"laminar specificity"},{"@attributes":{"MajorTopicYN":"N"},"@text":"neuroscience"},{"@attributes":{"MajorTopicYN":"N"},"@text":"transcription factors"}]}],"CoiStatement":"JP, IS, CA, BG, CT, ZS, CX, AK, MS, MP No competing interests declared"},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"received"},"Year":"2017","Month":"11","Day":"30"},{"@attributes":{"PubStatus":"accepted"},"Year":"2018","Month":"3","Day":"6"},{"@attributes":{"PubStatus":"pubmed"},"Year":"2018","Month":"3","Day":"8","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"medline"},"Year":"2019","Month":"7","Day":"2","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"entrez"},"Year":"2018","Month":"3","Day":"8","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"pmc-release"},"Year":"2018","Month":"3","Day":"7"}]},"PublicationStatus":"epublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"29513217"},{"@attributes":{"IdType":"pmc"},"@text":"PMC5854465"},{"@attributes":{"IdType":"doi"},"@text":"10.7554\/eLife.33962"},{"@attributes":{"IdType":"pii"},"@text":"33962"}]},"ReferenceList":[{"Reference":[{"Citation":"Akin O, Zipursky SL. Frazzled promotes growth cone attachment at the source of a Netrin gradient in the\u00a0Drosophila\u00a0visual system. eLife. 2016;5:e20762. doi: 10.7554\/eLife.20762.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.7554\/eLife.20762"},{"@attributes":{"IdType":"pmc"},"@text":"PMC5108592"},{"@attributes":{"IdType":"pubmed"},"@text":"27743477"}]}},{"Citation":"Baier H. Synaptic laminae in the visual system: molecular mechanisms forming layers of perception. Annual Review of Cell and Developmental Biology. 2013;29:385\u2013416. doi: 10.1146\/annurev-cellbio-101011-155748.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1146\/annurev-cellbio-101011-155748"},{"@attributes":{"IdType":"pubmed"},"@text":"24099086"}]}},{"Citation":"Carrillo RA, \u00d6zkan E, Menon KP, Nagarkar-Jaiswal S, Lee PT, Jeon M, Birnbaum ME, Bellen HJ, Garcia KC, Zinn K. Control of synaptic connectivity by a network of drosophila IGSF cell surface proteins. Cell. 2015;163:1770\u20131782. doi: 10.1016\/j.cell.2015.11.022.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.cell.2015.11.022"},{"@attributes":{"IdType":"pmc"},"@text":"PMC4720259"},{"@attributes":{"IdType":"pubmed"},"@text":"26687361"}]}},{"Citation":"Chen B, Schaevitz LR, McConnell SK. Fezl regulates the differentiation and axon targeting of layer 5 subcortical projection neurons in cerebral cortex. PNAS. 2005a;102:17184\u201317189. doi: 10.1073\/pnas.0508732102.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1073\/pnas.0508732102"},{"@attributes":{"IdType":"pmc"},"@text":"PMC1282569"},{"@attributes":{"IdType":"pubmed"},"@text":"16284245"}]}},{"Citation":"Chen JG, Rasin MR, Kwan KY, Sestan N. Zfp312 is required for subcortical axonal projections and dendritic morphology of deep-layer pyramidal neurons of the cerebral cortex. PNAS. 2005b;102:17792\u201317797. doi: 10.1073\/pnas.0509032102.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1073\/pnas.0509032102"},{"@attributes":{"IdType":"pmc"},"@text":"PMC1308928"},{"@attributes":{"IdType":"pubmed"},"@text":"16314561"}]}},{"Citation":"Chen Y, Akin O, Nern A, Tsui CY, Pecot MY, Zipursky SL. Cell-type-specific labeling of synapses in vivo through synaptic tagging with recombination. Neuron. 2014;81:280\u2013293. doi: 10.1016\/j.neuron.2013.12.021.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.neuron.2013.12.021"},{"@attributes":{"IdType":"pmc"},"@text":"PMC4025979"},{"@attributes":{"IdType":"pubmed"},"@text":"24462095"}]}},{"Citation":"Dulal K, Silver B, Zhu H. Use of recombination-mediated genetic engineering for construction of rescue human cytomegalovirus bacterial artificial chromosome clones. Journal of Biomedicine and Biotechnology. 2012;2012:1\u201310. doi: 10.1155\/2012\/357147.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1155\/2012\/357147"},{"@attributes":{"IdType":"pmc"},"@text":"PMC3303630"},{"@attributes":{"IdType":"pubmed"},"@text":"22500089"}]}},{"Citation":"Fischbach K-F, Dittrich APM. The optic lobe of Drosophila melanogaster. I. A Golgi analysis of wild-type structure. Cell and Tissue Research. 1989;258:441 475. doi: 10.1007\/BF00218858.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1007\/BF00218858"}]}},{"Citation":"Gao S, Takemura SY, Ting CY, Huang S, Lu Z, Luan H, Rister J, Thum AS, Yang M, Hong ST, Wang JW, Odenwald WF, White BH, Meinertzhagen IA, Lee CH. The neural substrate of spectral preference in Drosophila. Neuron. 2008;60:328\u2013342. doi: 10.1016\/j.neuron.2008.08.010.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.neuron.2008.08.010"},{"@attributes":{"IdType":"pmc"},"@text":"PMC2665173"},{"@attributes":{"IdType":"pubmed"},"@text":"18957224"}]}},{"Citation":"Harzer H, Berger C, Conder R, Schmauss G, Knoblich JA. FACS purification of Drosophila larval neuroblasts for next-generation sequencing. Nature Protocols. 2013;8:1088\u20131099. doi: 10.1038\/nprot.2013.062.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1038\/nprot.2013.062"},{"@attributes":{"IdType":"pmc"},"@text":"PMC3930877"},{"@attributes":{"IdType":"pubmed"},"@text":"23660757"}]}},{"Citation":"Hasegawa E, Kitada Y, Kaido M, Takayama R, Awasaki T, Tabata T, Sato M. Concentric zones, cell migration and neuronal circuits in the Drosophila visual center. Development. 2011;138:983\u2013993. doi: 10.1242\/dev.058370.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1242\/dev.058370"},{"@attributes":{"IdType":"pubmed"},"@text":"21303851"}]}},{"Citation":"Hashimoto H, Itoh M, Yamanaka Y, Yamashita S, Shimizu T, Solnica-Krezel L, Hibi M, Hirano T. Zebrafish Dkk1 functions in forebrain specification and axial mesendoderm formation. Developmental Biology. 2000a;217:138\u2013152. doi: 10.1006\/dbio.1999.9537.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1006\/dbio.1999.9537"},{"@attributes":{"IdType":"pubmed"},"@text":"10625541"}]}},{"Citation":"Hashimoto H, Yabe T, Hirata T, Shimizu T, Bae Y, Yamanaka Y, Hirano T, Hibi M. Expression of the zinc finger gene fez-like in zebrafish forebrain. Mechanisms of Development. 2000b;97:191\u2013195. doi: 10.1016\/S0925-4773(00)00418-4.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/S0925-4773(00)00418-4"},{"@attributes":{"IdType":"pubmed"},"@text":"11025224"}]}},{"Citation":"Huberman AD, Clandinin TR, Baier H. Molecular and cellular mechanisms of lamina-specific axon targeting. Cold Spring Harbor Perspectives in Biology. 2010;2:a001743. doi: 10.1101\/cshperspect.a001743.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1101\/cshperspect.a001743"},{"@attributes":{"IdType":"pmc"},"@text":"PMC2829955"},{"@attributes":{"IdType":"pubmed"},"@text":"20300211"}]}},{"Citation":"Janssens DH, Komori H, Grbac D, Chen K, Koe CT, Wang H, Lee CY. Earmuff restricts progenitor cell potential by attenuating the competence to respond to self-renewal factors. Development. 2014;141:1036\u20131046. doi: 10.1242\/dev.106534.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1242\/dev.106534"},{"@attributes":{"IdType":"pmc"},"@text":"PMC3929404"},{"@attributes":{"IdType":"pubmed"},"@text":"24550111"}]}},{"Citation":"Kurusu M, Cording A, Taniguchi M, Menon K, Suzuki E, Zinn K. A screen of cell-surface molecules identifies leucine-rich repeat proteins as key mediators of synaptic target selection. Neuron. 2008;59:972\u2013985. doi: 10.1016\/j.neuron.2008.07.037.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.neuron.2008.07.037"},{"@attributes":{"IdType":"pmc"},"@text":"PMC2630283"},{"@attributes":{"IdType":"pubmed"},"@text":"18817735"}]}},{"Citation":"Lee T, Luo L. Mosaic analysis with a repressible cell marker for studies of gene function in neuronal morphogenesis. Neuron. 1999;22:451\u2013461. doi: 10.1016\/S0896-6273(00)80701-1.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/S0896-6273(00)80701-1"},{"@attributes":{"IdType":"pubmed"},"@text":"10197526"}]}},{"Citation":"Lodato S, Rouaux C, Quast KB, Jantrachotechatchawan C, Studer M, Hensch TK, Arlotta P. Excitatory projection neuron subtypes control the distribution of local inhibitory interneurons in the cerebral cortex. Neuron. 2011;69:763\u2013779. doi: 10.1016\/j.neuron.2011.01.015.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.neuron.2011.01.015"},{"@attributes":{"IdType":"pmc"},"@text":"PMC3061282"},{"@attributes":{"IdType":"pubmed"},"@text":"21338885"}]}},{"Citation":"Matsuo-Takasaki M, Lim JH, Beanan MJ, Sato SM, Sargent TD. Cloning and expression of a novel zinc finger gene, Fez, transcribed in the forebrain of Xenopus and mouse embryos. Mechanisms of Development. 2000;93:201\u2013204. doi: 10.1016\/S0925-4773(00)00264-1.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/S0925-4773(00)00264-1"},{"@attributes":{"IdType":"pubmed"},"@text":"10781957"}]}},{"Citation":"Matsuoka RL, Nguyen-Ba-Charvet KT, Parray A, Badea TC, Ch\u00e9dotal A, Kolodkin AL. Transmembrane semaphorin signalling controls laminar stratification in the mammalian retina. Nature. 2011;470:259\u2013263. doi: 10.1038\/nature09675.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1038\/nature09675"},{"@attributes":{"IdType":"pmc"},"@text":"PMC3063100"},{"@attributes":{"IdType":"pubmed"},"@text":"21270798"}]}},{"Citation":"Molyneaux BJ, Arlotta P, Hirata T, Hibi M, Macklis JD. Fezl is required for the birth and specification of corticospinal motor neurons. Neuron. 2005;47:817\u2013831. doi: 10.1016\/j.neuron.2005.08.030.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.neuron.2005.08.030"},{"@attributes":{"IdType":"pubmed"},"@text":"16157277"}]}},{"Citation":"Nagarkar-Jaiswal S, Lee P-T, Campbell ME, Chen K, Anguiano-Zarate S, Cantu Gutierrez M, Busby T, Lin W-W, He Y, Schulze KL, Booth BW, Evans-Holm M, Venken KJT, Levis RW, Spradling AC, Hoskins RA, Bellen HJ. A library of MiMICs allows tagging of genes and reversible, spatial and temporal knockdown of proteins in Drosophila. eLife. 2015;4:e05338. doi: 10.7554\/eLife.05338.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.7554\/eLife.05338"},{"@attributes":{"IdType":"pmc"},"@text":"PMC4379497"},{"@attributes":{"IdType":"pubmed"},"@text":"25824290"}]}},{"Citation":"Nakamura M, Baldwin D, Hannaford S, Palka J, Montell C. Defective proboscis extension response (DPR), a member of the Ig superfamily required for the gustatory response to salt. Journal of Neuroscience. 2002;22:3463\u20133472.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pmc"},"@text":"PMC6758379"},{"@attributes":{"IdType":"pubmed"},"@text":"11978823"}]}},{"Citation":"Nern A, Zhu Y, Zipursky SL. Local N-cadherin interactions mediate distinct steps in the targeting of lamina neurons. Neuron. 2008;58:34\u201341. doi: 10.1016\/j.neuron.2008.03.022.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.neuron.2008.03.022"},{"@attributes":{"IdType":"pmc"},"@text":"PMC2692379"},{"@attributes":{"IdType":"pubmed"},"@text":"18400161"}]}},{"Citation":"Pecot MY, Chen Y, Akin O, Chen Z, Tsui CY, Zipursky SL. Sequential axon-derived signals couple target survival and layer specificity in the Drosophila visual system. Neuron. 2014;82:320\u2013333. doi: 10.1016\/j.neuron.2014.02.045.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.neuron.2014.02.045"},{"@attributes":{"IdType":"pmc"},"@text":"PMC4304384"},{"@attributes":{"IdType":"pubmed"},"@text":"24742459"}]}},{"Citation":"Pecot MY, Tadros W, Nern A, Bader M, Chen Y, Zipursky SL. Multiple interactions control synaptic layer specificity in the Drosophila visual system. Neuron. 2013;77:299\u2013310. doi: 10.1016\/j.neuron.2012.11.007.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.neuron.2012.11.007"},{"@attributes":{"IdType":"pmc"},"@text":"PMC3684158"},{"@attributes":{"IdType":"pubmed"},"@text":"23352166"}]}},{"Citation":"Pfeiffer BD, Jenett A, Hammonds AS, Ngo TT, Misra S, Murphy C, Scully A, Carlson JW, Wan KH, Laverty TR, Mungall C, Svirskas R, Kadonaga JT, Doe CQ, Eisen MB, Celniker SE, Rubin GM. Tools for neuroanatomy and neurogenetics in Drosophila. PNAS. 2008;105:9715\u20139720. doi: 10.1073\/pnas.0803697105.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1073\/pnas.0803697105"},{"@attributes":{"IdType":"pmc"},"@text":"PMC2447866"},{"@attributes":{"IdType":"pubmed"},"@text":"18621688"}]}},{"Citation":"Picelli S, Faridani OR, Bj\u00f6rklund AK, Winberg G, Sagasser S, Sandberg R. Full-length RNA-seq from single cells using Smart-seq2. Nature Protocols. 2014;9:171\u2013181. doi: 10.1038\/nprot.2014.006.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1038\/nprot.2014.006"},{"@attributes":{"IdType":"pubmed"},"@text":"24385147"}]}},{"Citation":"Prakash S, Caldwell JC, Eberl DF, Clandinin TR. Drosophila N-cadherin mediates an attractive interaction between photoreceptor axons and their targets. Nature Neuroscience. 2005;8:443\u2013450. doi: 10.1038\/nn1415.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1038\/nn1415"},{"@attributes":{"IdType":"pmc"},"@text":"PMC2367251"},{"@attributes":{"IdType":"pubmed"},"@text":"15735641"}]}},{"Citation":"Sanes JR, Yamagata M. Formation of lamina-specific synaptic connections. Current Opinion in Neurobiology. 1999;9:79\u201387. doi: 10.1016\/S0959-4388(99)80010-5.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/S0959-4388(99)80010-5"},{"@attributes":{"IdType":"pubmed"},"@text":"10072367"}]}},{"Citation":"Sanes JR, Zipursky SL. Design principles of insect and vertebrate visual systems. Neuron. 2010;66:15\u201336. doi: 10.1016\/j.neuron.2010.01.018.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.neuron.2010.01.018"},{"@attributes":{"IdType":"pmc"},"@text":"PMC2871012"},{"@attributes":{"IdType":"pubmed"},"@text":"20399726"}]}},{"Citation":"Schindelin J, Arganda-Carreras I, Frise E, Kaynig V, Longair M, Pietzsch T, Preibisch S, Rueden C, Saalfeld S, Schmid B, Tinevez JY, White DJ, Hartenstein V, Eliceiri K, Tomancak P, Cardona A. Fiji: an open-source platform for biological-image analysis. Nature Methods. 2012;9:676\u2013682. doi: 10.1038\/nmeth.2019.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1038\/nmeth.2019"},{"@attributes":{"IdType":"pmc"},"@text":"PMC3855844"},{"@attributes":{"IdType":"pubmed"},"@text":"22743772"}]}},{"Citation":"Schneider CA, Rasband WS, Eliceiri KW. NIH Image to ImageJ: 25 years of image analysis. Nature Methods. 2012;9:671\u2013675. doi: 10.1038\/nmeth.2089.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1038\/nmeth.2089"},{"@attributes":{"IdType":"pmc"},"@text":"PMC5554542"},{"@attributes":{"IdType":"pubmed"},"@text":"22930834"}]}},{"Citation":"Selleck SB, Steller H. The influence of retinal innervation on neurogenesis in the first optic ganglion of Drosophila. Neuron. 1991;6:83\u201399. doi: 10.1016\/0896-6273(91)90124-I.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/0896-6273(91)90124-I"},{"@attributes":{"IdType":"pubmed"},"@text":"1898850"}]}},{"Citation":"Sharan SK, Thomason LC, Kuznetsov SG, Court DL. Recombineering: a homologous recombination-based method of genetic engineering. Nature Protocols. 2009;4:206\u2013223. doi: 10.1038\/nprot.2008.227.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1038\/nprot.2008.227"},{"@attributes":{"IdType":"pmc"},"@text":"PMC2790811"},{"@attributes":{"IdType":"pubmed"},"@text":"19180090"}]}},{"Citation":"Shekhar K, Lapan SW, Whitney IE, Tran NM, Macosko EZ, Kowalczyk M, Adiconis X, Levin JZ, Nemesh J, Goldman M, McCarroll SA, Cepko CL, Regev A, Sanes JR. Comprehensive classification of retinal bipolar neurons by single-cell transcriptomics. Cell. 2016;166:e1330. doi: 10.1016\/j.cell.2016.07.054.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.cell.2016.07.054"},{"@attributes":{"IdType":"pmc"},"@text":"PMC5003425"},{"@attributes":{"IdType":"pubmed"},"@text":"27565351"}]}},{"Citation":"Takemura SY, Bharioke A, Lu Z, Nern A, Vitaladevuni S, Rivlin PK, Katz WT, Olbris DJ, Plaza SM, Winston P, Zhao T, Horne JA, Fetter RD, Takemura S, Blazek K, Chang LA, Ogundeyi O, Saunders MA, Shapiro V, Sigmund C, Rubin GM, Scheffer LK, Meinertzhagen IA, Chklovskii DB. A visual motion detection circuit suggested by Drosophila connectomics. Nature. 2013;500:175\u2013181. doi: 10.1038\/nature12450.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1038\/nature12450"},{"@attributes":{"IdType":"pmc"},"@text":"PMC3799980"},{"@attributes":{"IdType":"pubmed"},"@text":"23925240"}]}},{"Citation":"Takemura SY, Lu Z, Meinertzhagen IA. Synaptic circuits of the Drosophila optic lobe: the input terminals to the medulla. The Journal of Comparative Neurology. 2008;509:493\u2013513. doi: 10.1002\/cne.21757.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1002\/cne.21757"},{"@attributes":{"IdType":"pmc"},"@text":"PMC2481516"},{"@attributes":{"IdType":"pubmed"},"@text":"18537121"}]}},{"Citation":"Takemura SY, Xu CS, Lu Z, Rivlin PK, Parag T, Olbris DJ, Plaza S, Zhao T, Katz WT, Umayam L, Weaver C, Hess HF, Horne JA, Nunez-Iglesias J, Aniceto R, Chang LA, Lauchie S, Nasca A, Ogundeyi O, Sigmund C, Takemura S, Tran J, Langille C, Le Lacheur K, McLin S, Shinomiya A, Chklovskii DB, Meinertzhagen IA, Scheffer LK. Synaptic circuits and their variations within different columns in the visual system of Drosophila. PNAS. 2015;112:13711\u201313716. doi: 10.1073\/pnas.1509820112.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1073\/pnas.1509820112"},{"@attributes":{"IdType":"pmc"},"@text":"PMC4640747"},{"@attributes":{"IdType":"pubmed"},"@text":"26483464"}]}},{"Citation":"Tan L, Zhang KX, Pecot MY, Nagarkar-Jaiswal S, Lee PT, Takemura SY, McEwen JM, Nern A, Xu S, Tadros W, Chen Z, Zinn K, Bellen HJ, Morey M, Zipursky SL. Ig superfamily ligand and receptor pairs expressed in synaptic partners in Drosophila. Cell. 2015;163:1756\u20131769. doi: 10.1016\/j.cell.2015.11.021.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.cell.2015.11.021"},{"@attributes":{"IdType":"pmc"},"@text":"PMC4804707"},{"@attributes":{"IdType":"pubmed"},"@text":"26687360"}]}},{"Citation":"Tichy AL, Ray A, Carlson JR. A new Drosophila POU gene, pdm3, acts in odor receptor expression and axon targeting of olfactory neurons. Journal of Neuroscience. 2008;28:7121\u20137129. doi: 10.1523\/JNEUROSCI.2063-08.2008.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1523\/JNEUROSCI.2063-08.2008"},{"@attributes":{"IdType":"pmc"},"@text":"PMC2572001"},{"@attributes":{"IdType":"pubmed"},"@text":"18614681"}]}},{"Citation":"Timofeev K, Joly W, Hadjieconomou D, Salecker I. Localized netrins act as positional cues to control layer-specific targeting of photoreceptor axons in Drosophila. Neuron. 2012;75:80\u201393. doi: 10.1016\/j.neuron.2012.04.037.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.neuron.2012.04.037"},{"@attributes":{"IdType":"pmc"},"@text":"PMC3398394"},{"@attributes":{"IdType":"pubmed"},"@text":"22794263"}]}},{"Citation":"Ting CY, Yonekura S, Chung P, Hsu SN, Robertson HM, Chiba A, Lee CH. Drosophila N-cadherin functions in the first stage of the two-stage layer-selection process of R7 photoreceptor afferents. Development. 2005;132:953\u2013963. doi: 10.1242\/dev.01661.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1242\/dev.01661"},{"@attributes":{"IdType":"pubmed"},"@text":"15673571"}]}},{"Citation":"Viswanathan S, Williams ME, Bloss EB, Stasevich TJ, Speer CM, Nern A, Pfeiffer BD, Hooks BM, Li WP, English BP, Tian T, Henry GL, Macklin JJ, Patel R, Gerfen CR, Zhuang X, Wang Y, Rubin GM, Looger LL. High-performance probes for light and electron microscopy. Nature Methods. 2015;12:568\u2013576. doi: 10.1038\/nmeth.3365.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1038\/nmeth.3365"},{"@attributes":{"IdType":"pmc"},"@text":"PMC4573404"},{"@attributes":{"IdType":"pubmed"},"@text":"25915120"}]}},{"Citation":"Warming S, Costantino N, Court DL, Jenkins NA, Copeland NG. Simple and highly efficient BAC recombineering using galK selection. Nucleic Acids Research. 2005;33:e36. doi: 10.1093\/nar\/gni035.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1093\/nar\/gni035"},{"@attributes":{"IdType":"pmc"},"@text":"PMC549575"},{"@attributes":{"IdType":"pubmed"},"@text":"15731329"}]}},{"Citation":"Weng M, Golden KL, Lee CY. dFezf\/Earmuff maintains the restricted developmental potential of intermediate neural progenitors in Drosophila. Developmental Cell. 2010;18:126\u2013135. doi: 10.1016\/j.devcel.2009.12.007.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.devcel.2009.12.007"},{"@attributes":{"IdType":"pmc"},"@text":"PMC6699514"},{"@attributes":{"IdType":"pubmed"},"@text":"20152183"}]}},{"Citation":"Williams TM, Selegue JE, Werner T, Gompel N, Kopp A, Carroll SB. The regulation and evolution of a genetic switch controlling sexually dimorphic traits in Drosophila. Cell. 2008;134:610\u2013623. doi: 10.1016\/j.cell.2008.06.052.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.cell.2008.06.052"},{"@attributes":{"IdType":"pmc"},"@text":"PMC2597198"},{"@attributes":{"IdType":"pubmed"},"@text":"18724934"}]}},{"Citation":"\u00d6zkan E, Carrillo RA, Eastman CL, Weiszmann R, Waghray D, Johnson KG, Zinn K, Celniker SE, Garcia KC. An extracellular interactome of immunoglobulin and LRR proteins reveals receptor-ligand networks. Cell. 2013;154:228\u2013239. doi: 10.1016\/j.cell.2013.06.006.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.cell.2013.06.006"},{"@attributes":{"IdType":"pmc"},"@text":"PMC3756661"},{"@attributes":{"IdType":"pubmed"},"@text":"23827685"}]}}]}]}}}