{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"34161768"},"DateCompleted":{"Year":"2022","Month":"02","Day":"11"},"DateRevised":{"Year":"2024","Month":"02","Day":"26"},"Article":{"@attributes":{"PubModel":"Print"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Electronic"},"@text":"2211-1247"},"JournalIssue":{"@attributes":{"CitedMedium":"Internet"},"Volume":"35","Issue":"12","PubDate":{"Year":"2021","Month":"Jun","Day":"22"}},"Title":"Cell reports","ISOAbbreviation":"Cell Rep"},"ArticleTitle":"Transcriptional repression by FEZF2 restricts alternative identities of cortical projection neurons.","Pagination":{"StartPage":"109269","MedlinePgn":"109269"},"ELocationID":[{"@attributes":{"EIdType":"doi","ValidYN":"Y"},"@text":"10.1016\/j.celrep.2021.109269"},{"@attributes":{"EIdType":"pii","ValidYN":"Y"},"@text":"S2211-1247(21)00636-7"}],"Abstract":{"AbstractText":["Projection neuron subtype identities in the cerebral cortex are established by expressing pan-cortical and subtype-specific effector genes that execute terminal differentiation programs bestowing neurons with a glutamatergic neuron phenotype and subtype-specific morphology, physiology, and axonal projections. Whether pan-cortical glutamatergic and subtype-specific characteristics are regulated by the same genes or controlled by distinct programs remains largely unknown. Here, we show that FEZF2 functions as a transcriptional repressor, and it regulates subtype-specific identities of both corticothalamic and subcerebral neurons by selectively repressing expression of genes inappropriate for each neuronal subtype. We report that TLE4, specifically expressed in layer 6 corticothalamic neurons, is recruited by FEZF2 to inhibit layer 5 subcerebral neuronal genes. Together with previous studies, our results indicate that a cortical glutamatergic identity is specified by multiple parallel pathways active in progenitor cells, whereas projection neuron subtype-specific identity is achieved through selectively repressing genes associated with alternate identities in differentiating neurons."],"CopyrightInformation":"Published by Elsevier Inc."},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Tsyporin","ForeName":"Jeremiah","Initials":"J","AffiliationInfo":[{"Affiliation":"Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Tastad","ForeName":"David","Initials":"D","AffiliationInfo":[{"Affiliation":"Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Ma","ForeName":"Xiaokuang","Initials":"X","AffiliationInfo":[{"Affiliation":"Department of Basic Medical Sciences, University of Arizona College of Medicine - Phoenix, Phoenix, AZ 85004, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Nehme","ForeName":"Antoine","Initials":"A","AffiliationInfo":[{"Affiliation":"Department of Basic Medical Sciences, University of Arizona College of Medicine - Phoenix, Phoenix, AZ 85004, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Finn","ForeName":"Thomas","Initials":"T","AffiliationInfo":[{"Affiliation":"Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Huebner","ForeName":"Liora","Initials":"L","AffiliationInfo":[{"Affiliation":"Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Liu","ForeName":"Guoping","Initials":"G","AffiliationInfo":[{"Affiliation":"State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institute for Translational Brain Research, Institutes of Brain Science, Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Gallardo","ForeName":"Daisy","Initials":"D","AffiliationInfo":[{"Affiliation":"Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Makhamreh","ForeName":"Amr","Initials":"A","AffiliationInfo":[{"Affiliation":"Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Roberts","ForeName":"Jacqueline M","Initials":"JM","AffiliationInfo":[{"Affiliation":"Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Katzman","ForeName":"Solomon","Initials":"S","AffiliationInfo":[{"Affiliation":"Genomics Institute, University of California, Santa Cruz, Santa Cruz, CA 95064, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Sestan","ForeName":"Nenad","Initials":"N","AffiliationInfo":[{"Affiliation":"Department of Neuroscience, Yale School of Medicine, New Haven, CT 06520, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"McConnell","ForeName":"Susan K","Initials":"SK","AffiliationInfo":[{"Affiliation":"Department of Biology, Stanford University, Stanford, CA 94305, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Yang","ForeName":"Zhengang","Initials":"Z","AffiliationInfo":[{"Affiliation":"State Key Laboratory of Medical Neurobiology and MOE Frontiers Center for Brain Science, Institute for Translational Brain Research, Institutes of Brain Science, Department of Neurology, Zhongshan Hospital, Fudan University, Shanghai 200032, China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Qiu","ForeName":"Shenfeng","Initials":"S","AffiliationInfo":[{"Affiliation":"Department of Basic Medical Sciences, University of Arizona College of Medicine - Phoenix, Phoenix, AZ 85004, USA."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Chen","ForeName":"Bin","Initials":"B","AffiliationInfo":[{"Affiliation":"Department of Molecular, Cell, and Developmental Biology, University of California, Santa Cruz, 1156 High Street, Santa Cruz, CA 95064, USA. Electronic address: bchen@ucsc.edu."}]}]},"Language":["eng"],"GrantList":{"@attributes":{"CompleteYN":"Y"},"Grant":[{"GrantID":"R01 NS089777","Acronym":"NS","Agency":"NINDS NIH HHS","Country":"United States"},{"GrantID":"S10 OD023528","Acronym":"OD","Agency":"NIH HHS","Country":"United States"},{"GrantID":"R01 MH094589","Acronym":"MH","Agency":"NIMH NIH HHS","Country":"United States"},{"GrantID":"R01 NS095654","Acronym":"NS","Agency":"NINDS NIH HHS","Country":"United States"},{"GrantID":"R01 EY008411","Acronym":"EY","Agency":"NEI NIH HHS","Country":"United States"},{"GrantID":"U01 MH116488","Acronym":"MH","Agency":"NIMH NIH HHS","Country":"United States"}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D052061"},"@text":"Research Support, N.I.H., Extramural"},{"@attributes":{"UI":"D013485"},"@text":"Research Support, Non-U.S. Gov't"}]}},"MedlineJournalInfo":{"Country":"United States","MedlineTA":"Cell Rep","NlmUniqueID":"101573691"},"ChemicalList":{"Chemical":[{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D004268"},"@text":"DNA-Binding Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D009419"},"@text":"Nerve Tissue Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D012097"},"@text":"Repressor Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C434949"},"@text":"Tle4 protein, mouse"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C412364"},"@text":"Zfp312 protein, mouse"}}]},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D000483","MajorTopicYN":"N"},"@text":"Alleles"}},{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D002454","MajorTopicYN":"N"},"@text":"Cell Differentiation"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D002540","MajorTopicYN":"N"},"@text":"Cerebral Cortex"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"Y"},"@text":"cytology"}]},{"DescriptorName":{"@attributes":{"UI":"D004268","MajorTopicYN":"N"},"@text":"DNA-Binding Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D055724","MajorTopicYN":"N"},"@text":"Electrophysiological Phenomena"}},{"DescriptorName":{"@attributes":{"UI":"D005786","MajorTopicYN":"N"},"@text":"Gene Expression Regulation"}},{"DescriptorName":{"@attributes":{"UI":"D018345","MajorTopicYN":"N"},"@text":"Mice, Knockout"}},{"DescriptorName":{"@attributes":{"UI":"D008938","MajorTopicYN":"N"},"@text":"Mitosis"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D009419","MajorTopicYN":"N"},"@text":"Nerve Tissue Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D009474","MajorTopicYN":"N"},"@text":"Neurons"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"N"},"@text":"cytology"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D011485","MajorTopicYN":"N"},"@text":"Protein Binding"}},{"DescriptorName":{"@attributes":{"UI":"D012097","MajorTopicYN":"N"},"@text":"Repressor Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D014158","MajorTopicYN":"Y"},"@text":"Transcription, Genetic"}},{"DescriptorName":{"@attributes":{"UI":"D051379","MajorTopicYN":"N"},"@text":"Mice"}}]},"KeywordList":[{"@attributes":{"Owner":"NOTNLM"},"Keyword":[{"@attributes":{"MajorTopicYN":"N"},"@text":"Fezf2"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Tle4"},{"@attributes":{"MajorTopicYN":"N"},"@text":"cell fate"},{"@attributes":{"MajorTopicYN":"N"},"@text":"cerebral cortex"},{"@attributes":{"MajorTopicYN":"N"},"@text":"cortical projection neurons"},{"@attributes":{"MajorTopicYN":"N"},"@text":"subtype identity"},{"@attributes":{"MajorTopicYN":"N"},"@text":"transcription factor"},{"@attributes":{"MajorTopicYN":"N"},"@text":"transcriptional repressor"}]}],"CoiStatement":"Declaration of interests The authors declare no competing interests."},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"received"},"Year":"2020","Month":"3","Day":"6"},{"@attributes":{"PubStatus":"revised"},"Year":"2021","Month":"4","Day":"5"},{"@attributes":{"PubStatus":"accepted"},"Year":"2021","Month":"5","Day":"27"},{"@attributes":{"PubStatus":"entrez"},"Year":"2021","Month":"6","Day":"23","Hour":"20","Minute":"6"},{"@attributes":{"PubStatus":"pubmed"},"Year":"2021","Month":"6","Day":"24","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"medline"},"Year":"2022","Month":"2","Day":"12","Hour":"6","Minute":"0"},{"@attributes":{"PubStatus":"pmc-release"},"Year":"2021","Month":"8","Day":"2"}]},"PublicationStatus":"ppublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"34161768"},{"@attributes":{"IdType":"mid"},"@text":"NIHMS1717853"},{"@attributes":{"IdType":"pmc"},"@text":"PMC8327856"},{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.celrep.2021.109269"},{"@attributes":{"IdType":"pii"},"@text":"S2211-1247(21)00636-7"}]},"ReferenceList":[{"Reference":[{"Citation":"Agarwal 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