{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Automated"},"PMID":{"@attributes":{"Version":"1"},"@text":"37358764"},"DateCompleted":{"Year":"2023","Month":"07","Day":"31"},"DateRevised":{"Year":"2023","Month":"08","Day":"29"},"Article":{"@attributes":{"PubModel":"Print-Electronic"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Electronic"},"@text":"1573-4978"},"JournalIssue":{"@attributes":{"CitedMedium":"Internet"},"Volume":"50","Issue":"8","PubDate":{"Year":"2023","Month":"Aug"}},"Title":"Molecular biology reports","ISOAbbreviation":"Mol Biol Rep"},"ArticleTitle":"The role of GLUT2 in glucose metabolism in multiple organs and tissues.","Pagination":{"StartPage":"6963","EndPage":"6974","MedlinePgn":"6963-6974"},"ELocationID":[{"@attributes":{"EIdType":"doi","ValidYN":"Y"},"@text":"10.1007\/s11033-023-08535-w"}],"Abstract":{"AbstractText":["The glucose transporter family has an important role in the initial stage of glucose metabolism; Glucose transporters 2 (GLUTs, encoded by the solute carrier family 2, SLC2A genes) is the major glucose transporter in \u03b2-cells of pancreatic islets and hepatocytes but is also expressed in the small intestine, kidneys, and central nervous system; GLUT2 has a relatively low affinity to glucose. Under physiological conditions, GLUT2 transports glucose into cells and allows the glucose concentration to reach balance on the bilateral sides of the cellular membrane; Variation of GLUT2 is associated with various endocrine and metabolic disorders; In this study, we discussed the role of GLUT2 in participating in glucose metabolism and regulation in multiple organs and tissues and its effects on maintaining glucose homeostasis."],"CopyrightInformation":"\u00a9 2023. The Author(s)."},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Sun","ForeName":"Bo","Initials":"B","AffiliationInfo":[{"Affiliation":"Endorcrine and Metabolism Department, Lanzhou University Second Hospital, Lanzhou, 730000, China."},{"Affiliation":"Department of Infantile Endocrine Genetic Metabolism, Gansu Maternal and child Health Care Hospital, Lanzhou, 730000, China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Chen","ForeName":"Hui","Initials":"H","Identifier":[{"@attributes":{"Source":"ORCID"},"@text":"0000-0001-5717-1503"}],"AffiliationInfo":[{"Affiliation":"Endorcrine and Metabolism Department, Lanzhou University Second Hospital, Lanzhou, 730000, China. chenhui@lzu.edu.com."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Xue","ForeName":"Jisu","Initials":"J","AffiliationInfo":[{"Affiliation":"EndEnorcrine and Metabolism Department, Shenzhen Bao 'an People's Hospital (Group), Shenzhen, 518100, China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Li","ForeName":"Peiwu","Initials":"P","AffiliationInfo":[{"Affiliation":"Key Laboratory of Emergency Medicine, Lanzhou University Second Hospital, Lanzhou, 730000, China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Fu","ForeName":"Xu","Initials":"X","AffiliationInfo":[{"Affiliation":"Key Laboratory of Emergency Medicine, Lanzhou University Second Hospital, Lanzhou, 730000, China."}]}]},"Language":["eng"],"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D016454"},"@text":"Review"}]},"ArticleDate":[{"@attributes":{"DateType":"Electronic"},"Year":"2023","Month":"06","Day":"26"}]},"MedlineJournalInfo":{"Country":"Netherlands","MedlineTA":"Mol Biol Rep","NlmUniqueID":"0403234","ISSNLinking":"0301-4851"},"ChemicalList":{"Chemical":[{"RegistryNumber":"IY9XDZ35W2","NameOfSubstance":{"@attributes":{"UI":"D005947"},"@text":"Glucose"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D051246"},"@text":"Glucose Transport Proteins, Facilitative"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D051273"},"@text":"Glucose Transporter Type 2"}}]},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D005947","MajorTopicYN":"Y"},"@text":"Glucose"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D007515","MajorTopicYN":"Y"},"@text":"Islets of Langerhans"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D051246","MajorTopicYN":"N"},"@text":"Glucose Transport Proteins, Facilitative"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D022781","MajorTopicYN":"N"},"@text":"Hepatocytes"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D001692","MajorTopicYN":"N"},"@text":"Biological Transport"}},{"DescriptorName":{"@attributes":{"UI":"D051273","MajorTopicYN":"N"},"@text":"Glucose Transporter Type 2"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]}]},"KeywordList":[{"@attributes":{"Owner":"NOTNLM"},"Keyword":[{"@attributes":{"MajorTopicYN":"N"},"@text":"Blood glucose homeostasis"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Blood glucose regulation"},{"@attributes":{"MajorTopicYN":"N"},"@text":"GLUT2"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Glucose metabolism"}]}],"CoiStatement":"Bo Sun, Hui Chen, Jisu Xue, Feiwu Li, Xu Fu declare that they have no competing interests."},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"received"},"Year":"2022","Month":"12","Day":"12"},{"@attributes":{"PubStatus":"accepted"},"Year":"2023","Month":"5","Day":"17"},{"@attributes":{"PubStatus":"medline"},"Year":"2023","Month":"7","Day":"31","Hour":"11","Minute":"42"},{"@attributes":{"PubStatus":"pubmed"},"Year":"2023","Month":"6","Day":"26","Hour":"13","Minute":"7"},{"@attributes":{"PubStatus":"entrez"},"Year":"2023","Month":"6","Day":"26","Hour":"11","Minute":"14"},{"@attributes":{"PubStatus":"pmc-release"},"Year":"2023","Month":"6","Day":"26"}]},"PublicationStatus":"ppublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"37358764"},{"@attributes":{"IdType":"pmc"},"@text":"PMC10374759"},{"@attributes":{"IdType":"doi"},"@text":"10.1007\/s11033-023-08535-w"},{"@attributes":{"IdType":"pii"},"@text":"10.1007\/s11033-023-08535-w"}]},"ReferenceList":[{"Reference":[{"Citation":"Sala-Rabanal M, Hirayama BA, Ghezzi C, Liu J, Huang SC, Kepe V, Koepsell H, Yu A, Powell DR, Thorens B, Wright EM, Barrio JR. 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