{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Automated"},"PMID":{"@attributes":{"Version":"1"},"@text":"41315759"},"DateCompleted":{"Year":"2025","Month":"11","Day":"29"},"DateRevised":{"Year":"2025","Month":"12","Day":"01"},"Article":{"@attributes":{"PubModel":"Electronic"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Electronic"},"@text":"2399-3642"},"JournalIssue":{"@attributes":{"CitedMedium":"Internet"},"Volume":"8","Issue":"1","PubDate":{"Year":"2025","Month":"Nov","Day":"28"}},"Title":"Communications biology","ISOAbbreviation":"Commun Biol"},"ArticleTitle":"Neuronal activity-induced GLUT3 plasma translocation supports energy demands for memory acquisition.","Pagination":{"StartPage":"1716","MedlinePgn":"1716"},"ELocationID":[{"@attributes":{"EIdType":"pii","ValidYN":"Y"},"@text":"1716"},{"@attributes":{"EIdType":"doi","ValidYN":"Y"},"@text":"10.1038\/s42003-025-09119-z"}],"Abstract":{"AbstractText":["Glucose transporter 3 (GLUT3) is crucial for glucose uptake in neurons and rapidly translocates to the plasma membrane in response to neural activity. However, the precise molecular mechanisms and physiological roles of this translocation remain elusive, hindering our understanding of how glucose metabolism supports brain function. This study found that PKC\u03b5 phosphorylates Thr232 and Ser246 of GLUT3 upon neuronal activation, enhancing its binding to KLC1 and promoting GLUT3 plasma membrane insertion. To investigate the function of GLUT3 plasma translocation, we developed a peptide, TAT-GLUT3(2D), which disrupts GLUT3-KLC1 binding and blocks activity-dependent translocation of GLUT3. By utilizing TAT-GLUT3(2D), we showed that blockage of activity-induced GLUT3 neuronal surface translocation leads to decreased glucose uptake and ATP production, impairing memory acquisition without affecting memory consolidation or retrieval in mice. Our results suggest that PKC\u03b5-mediated phosphorylation of GLUT3 is a key regulator of neuronal activity-induced GLUT3 plasma membrane insertion and memory acquisition, advancing our understanding of the energy supply needed for memory acquisition."],"CopyrightInformation":"\u00a9 2025. The Author(s)."},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y","EqualContrib":"Y"},"LastName":"Wei","ForeName":"Xin-Yue","Initials":"XY","Identifier":[{"@attributes":{"Source":"ORCID"},"@text":"0009-0003-1192-1374"}],"AffiliationInfo":[{"Affiliation":"Department of Anatomy and Neurobiology, Shandong Key Laboratory of Mental Disorders and Intelligent Control, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China."}]},{"@attributes":{"ValidYN":"Y","EqualContrib":"Y"},"LastName":"Zou","ForeName":"Ze-Ming","Initials":"ZM","AffiliationInfo":[{"Affiliation":"Department of Anatomy and Neurobiology, Shandong Key Laboratory of Mental Disorders and Intelligent Control, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Yao","ForeName":"Zhong-Xiao","Initials":"ZX","AffiliationInfo":[{"Affiliation":"Department of Anatomy and Neurobiology, Shandong Key Laboratory of Mental Disorders and Intelligent Control, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Teng","ForeName":"Shuai-Wen","Initials":"SW","AffiliationInfo":[{"Affiliation":"Department of Anatomy and Neurobiology, Shandong Key Laboratory of Mental Disorders and Intelligent Control, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China."},{"Affiliation":"Research Center for Basic Medical Sciences, Qilu Hospital of Shandong University, Jinan, Shandong, P.R. China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Wei","ForeName":"Xin-Yu","Initials":"XY","AffiliationInfo":[{"Affiliation":"Department of Anatomy and Neurobiology, Shandong Key Laboratory of Mental Disorders and Intelligent Control, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Tang","ForeName":"Wen-Jie","Initials":"WJ","AffiliationInfo":[{"Affiliation":"Department of Anatomy and Neurobiology, Shandong Key Laboratory of Mental Disorders and Intelligent Control, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Chen","ForeName":"Xiao-Lin","Initials":"XL","AffiliationInfo":[{"Affiliation":"Department of Anatomy and Neurobiology, Shandong Key Laboratory of Mental Disorders and Intelligent Control, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"He","ForeName":"Yun-Zhang","Initials":"YZ","AffiliationInfo":[{"Affiliation":"Department of Anatomy and Neurobiology, Shandong Key Laboratory of Mental Disorders and Intelligent Control, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Chen","ForeName":"Zhe-Yu","Initials":"ZY","Identifier":[{"@attributes":{"Source":"ORCID"},"@text":"0000-0002-7092-8723"}],"AffiliationInfo":[{"Affiliation":"Department of Anatomy and Neurobiology, Shandong Key Laboratory of Mental Disorders and Intelligent Control, School of Basic Medical Sciences, Cheeloo College of Medicine, Shandong University, Jinan, Shandong, P.R. China. zheyuchen@sdu.edu.cn."},{"Affiliation":"Research Center for Basic Medical Sciences, Qilu Hospital of Shandong University, Jinan, Shandong, P.R. China. zheyuchen@sdu.edu.cn."},{"Affiliation":"State Key Laboratory for Innovation and Transformation of Luobing Theory, Jinan, China. zheyuchen@sdu.edu.cn."}]}]},"Language":["eng"],"GrantList":{"@attributes":{"CompleteYN":"Y"},"Grant":[{"GrantID":"32471068","Agency":"National Natural Science Foundation of China (National Science Foundation of China)","Country":""}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"}]},"ArticleDate":[{"@attributes":{"DateType":"Electronic"},"Year":"2025","Month":"11","Day":"28"}]},"MedlineJournalInfo":{"Country":"England","MedlineTA":"Commun Biol","NlmUniqueID":"101719179","ISSNLinking":"2399-3642"},"ChemicalList":{"Chemical":[{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D051274"},"@text":"Glucose Transporter Type 3"}},{"RegistryNumber":"IY9XDZ35W2","NameOfSubstance":{"@attributes":{"UI":"D005947"},"@text":"Glucose"}},{"RegistryNumber":"EC 2.7.11.13","NameOfSubstance":{"@attributes":{"UI":"D051744"},"@text":"Protein Kinase C-epsilon"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C495689"},"@text":"Slc2a3 protein, mouse"}}]},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D051274","MajorTopicYN":"Y"},"@text":"Glucose Transporter Type 3"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"},{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D009474","MajorTopicYN":"Y"},"@text":"Neurons"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D051379","MajorTopicYN":"N"},"@text":"Mice"}},{"DescriptorName":{"@attributes":{"UI":"D010766","MajorTopicYN":"N"},"@text":"Phosphorylation"}},{"DescriptorName":{"@attributes":{"UI":"D002462","MajorTopicYN":"N"},"@text":"Cell Membrane"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D021381","MajorTopicYN":"N"},"@text":"Protein Transport"}},{"DescriptorName":{"@attributes":{"UI":"D004734","MajorTopicYN":"Y"},"@text":"Energy Metabolism"}},{"DescriptorName":{"@attributes":{"UI":"D008568","MajorTopicYN":"Y"},"@text":"Memory"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"N"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D005947","MajorTopicYN":"N"},"@text":"Glucose"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D008297","MajorTopicYN":"N"},"@text":"Male"}},{"DescriptorName":{"@attributes":{"UI":"D051744","MajorTopicYN":"N"},"@text":"Protein Kinase C-epsilon"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D008810","MajorTopicYN":"N"},"@text":"Mice, Inbred C57BL"}},{"DescriptorName":{"@attributes":{"UI":"D006801","MajorTopicYN":"N"},"@text":"Humans"}}]},"CoiStatement":"Competing interests: The authors declare no competing interests."},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"received"},"Year":"2025","Month":"2","Day":"21"},{"@attributes":{"PubStatus":"accepted"},"Year":"2025","Month":"10","Day":"17"},{"@attributes":{"PubStatus":"medline"},"Year":"2025","Month":"11","Day":"29","Hour":"6","Minute":"29"},{"@attributes":{"PubStatus":"pubmed"},"Year":"2025","Month":"11","Day":"29","Hour":"2","Minute":"21"},{"@attributes":{"PubStatus":"entrez"},"Year":"2025","Month":"11","Day":"29","Hour":"0","Minute":"30"},{"@attributes":{"PubStatus":"pmc-release"},"Year":"2025","Month":"11","Day":"28"}]},"PublicationStatus":"epublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"41315759"},{"@attributes":{"IdType":"pmc"},"@text":"PMC12663466"},{"@attributes":{"IdType":"doi"},"@text":"10.1038\/s42003-025-09119-z"},{"@attributes":{"IdType":"pii"},"@text":"10.1038\/s42003-025-09119-z"}]},"ReferenceList":[{"Reference":[{"Citation":"Magistretti, P. 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