{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"Publisher","Owner":"NLM"},"PMID":{"@attributes":{"Version":"1"},"@text":"41655632"},"DateRevised":{"Year":"2026","Month":"02","Day":"08"},"Article":{"@attributes":{"PubModel":"Print-Electronic"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Print"},"@text":"1673-8527"},"JournalIssue":{"@attributes":{"CitedMedium":"Internet"},"PubDate":{"Year":"2026","Month":"Feb","Day":"06"}},"Title":"Journal of genetics and genomics = Yi chuan xue bao","ISOAbbreviation":"J Genet Genomics"},"ArticleTitle":"The ultra-conserved lncRNA Crnde regulates neural differentiation by targeting Gbx2 during embryonic development of the thalamus.","ELocationID":[{"@attributes":{"EIdType":"pii","ValidYN":"Y"},"@text":"S1673-8527(26)00046-9"},{"@attributes":{"EIdType":"doi","ValidYN":"Y"},"@text":"10.1016\/j.jgg.2026.02.002"}],"Abstract":{"AbstractText":["The thalamus regulates sensory processing, cognition, and sleep, yet the molecular mechanisms underlying its development remain incompletely understood. Long noncoding RNAs (lncRNAs), particularly evolutionarily conserved ones, are highly enriched in the brain. Using public mRNA databases, we screen for lncRNAs with embryonic brain expression and harboring ultraconserved non-coding elements (UCNEs) in humans and mice, identifying colorectal neoplasia differentially expressed (Crnde). It exhibits stage-specific upregulation in the embryonic thalamus. The Database of Genomic Variation and Phenotype in Humans using Ensembl Resources (DECIPHER) database suggests a potential association between Crnde and intellectual disability. Crnde-deficient mice display anxiety-like behaviors and spatial memory deficits. Furthermore, Crnde ablation increases progenitor cell numbers and impairs neuronal differentiation during embryonic thalamic development. Mechanistically, Crnde modulates the mRNA expression of gastrulation brain homeobox 2 (Gbx2), a gene critical for thalamic development. Collectively, our results implicate lncRNA Crnde in the proper progression of embryonic thalamic development in mice."],"CopyrightInformation":"Copyright \u00a9 2026. Published by Elsevier Ltd."},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Hu","ForeName":"Wen-Zhu","Initials":"WZ","AffiliationInfo":[{"Affiliation":"Department of Epidemiology, School of Public Health, Southeast University, Nanjing, Jiangsu 211189, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Department of Epidemiology and Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Gu","ForeName":"Ya-Yun","Initials":"YY","AffiliationInfo":[{"Affiliation":"State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Department of Epidemiology and Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"He","ForeName":"Yuan-Lin","Initials":"YL","AffiliationInfo":[{"Affiliation":"State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Department of Epidemiology and Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Hong","ForeName":"Yuan","Initials":"Y","AffiliationInfo":[{"Affiliation":"Institute of Stem Cell and Neural Regeneration, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Department of Pharmacy, The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"He","ForeName":"Yue-Wen","Initials":"YW","AffiliationInfo":[{"Affiliation":"State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Zhang","ForeName":"Zi-Cheng","Initials":"ZC","AffiliationInfo":[{"Affiliation":"State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Wang","ForeName":"Yuan-Hao","Initials":"YH","AffiliationInfo":[{"Affiliation":"Institute of Stem Cell and Neural Regeneration, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Sun","ForeName":"Jia-Ning","Initials":"JN","AffiliationInfo":[{"Affiliation":"State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Han","ForeName":"Xiao","Initials":"X","AffiliationInfo":[{"Affiliation":"State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China; Institute of Stem Cell and Neural Regeneration, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, China. Electronic address: xhan1988@njmu.edu.cn."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Liu","ForeName":"Yan","Initials":"Y","AffiliationInfo":[{"Affiliation":"State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China; Institute of Stem Cell and Neural Regeneration, School of Pharmacy, Nanjing Medical University, Nanjing, Jiangsu 211166, China. Electronic address: yanliu@njmu.edu.cn."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Hu","ForeName":"Zhi-Bin","Initials":"ZB","AffiliationInfo":[{"Affiliation":"Department of Epidemiology, School of Public Health, Southeast University, Nanjing, Jiangsu 211189, China; State Key Laboratory of Reproductive Medicine and Offspring Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; Department of Epidemiology and Biostatistics, Center for Global Health, School of Public Health, Nanjing Medical University, Nanjing, Jiangsu 211166, China; State Key Laboratory of Reproductive Medicine and Offspring Health (Suzhou Centre), The Affiliated Suzhou Hospital of Nanjing Medical University, Suzhou Municipal Hospital, Gusu School, Nanjing Medical University, Suzhou, Jiangsu 215002, China. Electronic address: zhibin_hu@njmu.edu.cn."}]}]},"Language":["eng"],"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"}]},"ArticleDate":[{"@attributes":{"DateType":"Electronic"},"Year":"2026","Month":"02","Day":"06"}]},"MedlineJournalInfo":{"Country":"China","MedlineTA":"J Genet Genomics","NlmUniqueID":"101304616","ISSNLinking":"1673-8527"},"CitationSubset":["IM"],"KeywordList":[{"@attributes":{"Owner":"NOTNLM"},"Keyword":[{"@attributes":{"MajorTopicYN":"N"},"@text":"Crnde"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Intellectual disability"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Long noncoding RNA"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Neurodevelopmental disorders"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Neuronal differentiation"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Thalamus development"}]}],"CoiStatement":"Conflict of interest The authors declare that they have no competing interests."},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"received"},"Year":"2025","Month":"7","Day":"9"},{"@attributes":{"PubStatus":"revised"},"Year":"2026","Month":"2","Day":"1"},{"@attributes":{"PubStatus":"accepted"},"Year":"2026","Month":"2","Day":"1"},{"@attributes":{"PubStatus":"medline"},"Year":"2026","Month":"2","Day":"9","Hour":"0","Minute":"29"},{"@attributes":{"PubStatus":"pubmed"},"Year":"2026","Month":"2","Day":"9","Hour":"0","Minute":"29"},{"@attributes":{"PubStatus":"entrez"},"Year":"2026","Month":"2","Day":"8","Hour":"19","Minute":"12"}]},"PublicationStatus":"aheadofprint","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"41655632"},{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.jgg.2026.02.002"},{"@attributes":{"IdType":"pii"},"@text":"S1673-8527(26)00046-9"}]}}}}