{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"Publisher","Owner":"NLM"},"PMID":{"@attributes":{"Version":"1"},"@text":"41902978"},"DateRevised":{"Year":"2026","Month":"03","Day":"28"},"Article":{"@attributes":{"PubModel":"Print-Electronic"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Electronic"},"@text":"1573-2584"},"JournalIssue":{"@attributes":{"CitedMedium":"Internet"},"PubDate":{"Year":"2026","Month":"Mar","Day":"28"}},"Title":"International urology and nephrology","ISOAbbreviation":"Int Urol Nephrol"},"ArticleTitle":"Bibliometric analysis of Alport syndrome: genetic foundations, clinical implications, and the transition to precision medicine.","ELocationID":[{"@attributes":{"EIdType":"doi","ValidYN":"Y"},"@text":"10.1007\/s11255-026-05116-1"}],"Abstract":{"AbstractText":[{"@attributes":{"Label":"BACKGROUND","NlmCategory":"BACKGROUND"},"@text":"Alport syndrome is a rare genetic disorder characterized by progressive renal impairment, hearing loss, and ocular abnormalities. Our study aimed to elucidate global research trends on Alport syndrome through bibliometric analysis."},{"@attributes":{"Label":"METHODS","NlmCategory":"METHODS"},"@text":"A comprehensive bibliometric analysis of Alport syndrome literature (1990-2025) was performed using WoS and Scopus. After merging and de-duplication (n\u2009=\u20092371), CiteSpace, VOSviewer, and Bibliometrix facilitated network visualization, co-occurrence, co-citation, and historiographic evaluations."},{"@attributes":{"Label":"RESULTS","NlmCategory":"RESULTS"},"@text":"Research on Alport syndrome has grown exponentially since 1990 (2371 documents; 6.04% annual growth), dominated by original articles and moderate international collaboration. The USA leads in output, collaboration, and citations; China's volume is rising with evolving global impact. A hub-and-cluster author structure (e.g., Savige, Gross, Kashtan) publishes mainly in nephrology journals (Kidney International, JASN, Pediatric Nephrology), with interdisciplinary citation flows. Co-citation and bursts trace a shift from GBM\/type IV collagen genetics to precision diagnostics and renoprotective therapy. Landmark studies established COL4 mutations, genotype-phenotype links, and early ACE inhibition, defining a gene-structure-phenotype-therapy axis."},{"@attributes":{"Label":"CONCLUSION","NlmCategory":"CONCLUSIONS"},"@text":"Alport syndrome research has progressed from genetic discovery toward more integrative and precision-focused approaches, supported by expanding global collaboration and contributions from key nephrology journals. Emerging priorities-including earlier diagnosis, renoprotective strategies, and advanced molecular techniques-reflect a sustained shift toward more personalized research directions that may inform future clinical management."}],"CopyrightInformation":"\u00a9 2026. The Author(s), under exclusive licence to Springer Nature B.V."},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Tian","ForeName":"Hui","Initials":"H","AffiliationInfo":[{"Affiliation":"Beijing Hepingli Hospital, Beijing, China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Zhang","ForeName":"Minheng","Initials":"M","AffiliationInfo":[{"Affiliation":"Department of Gerontology, The First People's Hospital of Jinzhong, No. 689 Huitong South Road, Jinzhong City, 030600, Shanxi Province, China. zmhfhx@163.com."}]}]},"Language":["eng"],"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"}]},"ArticleDate":[{"@attributes":{"DateType":"Electronic"},"Year":"2026","Month":"03","Day":"28"}]},"MedlineJournalInfo":{"Country":"Netherlands","MedlineTA":"Int Urol Nephrol","NlmUniqueID":"0262521","ISSNLinking":"0301-1623"},"CitationSubset":["IM"],"KeywordList":[{"@attributes":{"Owner":"NOTNLM"},"Keyword":[{"@attributes":{"MajorTopicYN":"N"},"@text":"Alport syndrome"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Bibliometric analysis"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Genotype\u2013phenotype correlation"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Next-generation sequencing"},{"@attributes":{"MajorTopicYN":"N"},"@text":"RAAS blockade"}]}],"CoiStatement":"Declarations. Conflict of interest: The authors declare no competing interests. Ethical approval: An ethics statement was not required for this study type as it is based exclusively on published literature. Clinical trial number: Not applicable. This article does not contain any studies with human participants performed by any of the authors."},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"received"},"Year":"2026","Month":"2","Day":"10"},{"@attributes":{"PubStatus":"accepted"},"Year":"2026","Month":"3","Day":"21"},{"@attributes":{"PubStatus":"medline"},"Year":"2026","Month":"3","Day":"29","Hour":"7","Minute":"34"},{"@attributes":{"PubStatus":"pubmed"},"Year":"2026","Month":"3","Day":"29","Hour":"7","Minute":"34"},{"@attributes":{"PubStatus":"entrez"},"Year":"2026","Month":"3","Day":"28","Hour":"12","Minute":"16"}]},"PublicationStatus":"aheadofprint","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"41902978"},{"@attributes":{"IdType":"doi"},"@text":"10.1007\/s11255-026-05116-1"},{"@attributes":{"IdType":"pii"},"@text":"10.1007\/s11255-026-05116-1"}]},"ReferenceList":[{"Reference":[{"Citation":"Omachi K et al (2025) Anticodon-edited tRNA enables translational readthrough of COL4A5 premature termination codons. 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