{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"Publisher","Owner":"NLM"},"PMID":{"@attributes":{"Version":"1"},"@text":"41904366"},"DateRevised":{"Year":"2026","Month":"03","Day":"28"},"Article":{"@attributes":{"PubModel":"Print-Electronic"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Electronic"},"@text":"1573-742X"},"JournalIssue":{"@attributes":{"CitedMedium":"Internet"},"PubDate":{"Year":"2026","Month":"Mar","Day":"28"}},"Title":"Journal of thrombosis and thrombolysis","ISOAbbreviation":"J Thromb Thrombolysis"},"ArticleTitle":"Angio-Seal plug-based versus dual ProGlide for transfemoral hemostasis in transcatheter aortic valve replacement: a systematic review and meta-analysis.","ELocationID":[{"@attributes":{"EIdType":"doi","ValidYN":"Y"},"@text":"10.1007\/s11239-026-03261-z"}],"Abstract":{"AbstractText":["Transcatheter aortic valve replacement (TAVR) carries risks of vascular and bleeding complications. We aimed to study the effectiveness of Angio-Seal combined with Perclose ProGlide versus dual Perclose ProGlide following transfemoral TAVR. We searched PubMed, Cochrane Library, Scopus, and WOS from inception until November 2024 for studies comparing Parclose ProGlide with Angio-Seal versus dual Parclose ProGlide in transfemoral TAVR. The primary outcome was major vascular complications, while other secondary outcomes were bleeding complications, the need for additional vascular closure device (VCD), minor vascular complications, unplanned surgical intervention, mortality, hematoma, pseudoaneurysm, and dissection. Dichotomous outcomes were pooled and analyzed using odds ratio (OR) with 95% confidence interval (CI) via the DerSimonian-Laird random-effect model. Seven studies (two RCTs and five observational studies) comprising 1,766 patients were included. In RCT-only analyses, single Perclose ProGlide combined with Angio-Seal showed no significant difference compared with dual Perclose ProGlide in major vascular complications (OR\u2009=\u20090.54, 95% CI [0.28-1.04], P\u2009=\u20090.07) or major\/life-threatening bleeding (OR\u2009=\u20090.66, 95% CI [0.25-1.74], P\u2009=\u20090.40). However, it significantly reduced the need for additional vascular closure devices (OR\u2009=\u20090.11, 95% CI [0.05-0.24], P\u2009<\u20090.01) and minor vascular complications (OR\u2009=\u20090.52, 95% CI [0.38-0.72], P\u2009<\u20090.01). For dual Perclose ProGlide combined with Angio-Seal, no RCTs were available; observational evidence suggested a reduction in major\/life-threatening bleeding compared to dual Perclose ProGlide (OR\u2009=\u20090.43, 95% CI [0.21 to0.92], p\u2009=\u20090.03), while there was no significant difference between the two groups upon excluding Costa et al. (EuroIntervention, 17:728-735, 2021) (OR\u2009=\u20090.56, 95% CI [0.26 to 1.21], p\u2009=\u20090.14). Based on the available RCTs, the combination of single Perclose ProGlide with Angio-Seal during transfemoral TAVR significantly reduces the need for additional vascular closure devices. It may also reduce minor vascular complications, but this effect is not consistently robust. The pooled analysis of observational studies suggests a potential benefit of dual Perclose ProGlide combined with Angio-Seal for major\/life-threatening bleeding. However, this finding was not robust in sensitivity analyses and no RCTs have evaluated this strategy."],"CopyrightInformation":"\u00a9 2026. The Author(s)."},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Alnomani","ForeName":"Yousef Radwan","Initials":"YR","AffiliationInfo":[{"Affiliation":"Faculty of Medicine, Benha University, Benha, Egypt. yousefradwan2429@gmail.com."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Algazar","ForeName":"Mansour","Initials":"M","AffiliationInfo":[{"Affiliation":"Faculty of Medicine, Al-Azhar University, Asyut, Egypt."},{"Affiliation":"Medical Research group of Egypt (MRGE), Cairo, Egypt."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Omar","ForeName":"Mohamed Mosad","Initials":"MM","AffiliationInfo":[{"Affiliation":"Faculty of Medicine, Cairo University, Cairo, Egypt."},{"Affiliation":"Medical Research group of Egypt (MRGE), Cairo, Egypt."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Aldemerdash","ForeName":"Mohamed A","Initials":"MA","AffiliationInfo":[{"Affiliation":"Faculty of Medicine, Sohag university, Sohag, Egypt."},{"Affiliation":"Medical Research group of Egypt (MRGE), Cairo, Egypt."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Henes","ForeName":"Kerollos","Initials":"K","AffiliationInfo":[{"Affiliation":"Department of Cardiology, El-Mabarra Health Insurance Hospital, Asyut, Egypt."},{"Affiliation":"Medical Research group of Egypt (MRGE), Cairo, Egypt."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Arafa","ForeName":"Amr","Initials":"A","AffiliationInfo":[{"Affiliation":"Department of Nephrology, Alexandria University, Alexandria, Egypt."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Rageh","ForeName":"Bushra Muneer","Initials":"BM","AffiliationInfo":[{"Affiliation":"Department of Physiology, Sana'a University, Sana'a, Yemen."},{"Affiliation":"Medical Research group of Egypt (MRGE), Cairo, Egypt."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Abdelaziz","ForeName":"Ahmed","Initials":"A","AffiliationInfo":[{"Affiliation":"Division of Cardiology, Montefiore Health System\/Albert Einstein College of Medicine, Bronx, NY, USA."},{"Affiliation":"Medical Research group of Egypt (MRGE), Cairo, Egypt."}]}]},"Language":["eng"],"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D016454"},"@text":"Review"}]},"ArticleDate":[{"@attributes":{"DateType":"Electronic"},"Year":"2026","Month":"03","Day":"28"}]},"MedlineJournalInfo":{"Country":"Netherlands","MedlineTA":"J Thromb Thrombolysis","NlmUniqueID":"9502018","ISSNLinking":"0929-5305"},"CitationSubset":["IM"],"KeywordList":[{"@attributes":{"Owner":"NOTNLM"},"Keyword":[{"@attributes":{"MajorTopicYN":"N"},"@text":"Angio-Seal"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Closure device"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Perclose ProGlide"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Plug-based"},{"@attributes":{"MajorTopicYN":"N"},"@text":"Suture-based"},{"@attributes":{"MajorTopicYN":"N"},"@text":"TAVR"}]}],"CoiStatement":"Declarations. Competing interests: The authors declare no competing interests. Consent for publication: Not applicable. Ethical approval: Not applicable."},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"received"},"Year":"2025","Month":"12","Day":"23"},{"@attributes":{"PubStatus":"accepted"},"Year":"2026","Month":"2","Day":"27"},{"@attributes":{"PubStatus":"medline"},"Year":"2026","Month":"3","Day":"29","Hour":"7","Minute":"35"},{"@attributes":{"PubStatus":"pubmed"},"Year":"2026","Month":"3","Day":"29","Hour":"7","Minute":"35"},{"@attributes":{"PubStatus":"entrez"},"Year":"2026","Month":"3","Day":"28","Hour":"23","Minute":"19"}]},"PublicationStatus":"aheadofprint","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"41904366"},{"@attributes":{"IdType":"doi"},"@text":"10.1007\/s11239-026-03261-z"},{"@attributes":{"IdType":"pii"},"@text":"10.1007\/s11239-026-03261-z"}]},"ReferenceList":[{"Reference":[{"Citation":"Arora S, Misenheimer JA, Ramaraj R (2017) Transcatheter aortic valve replacement: comprehensive review and present status. 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