{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Automated"},"PMID":{"@attributes":{"Version":"1"},"@text":"41970969"},"DateCompleted":{"Year":"2026","Month":"04","Day":"13"},"DateRevised":{"Year":"2026","Month":"04","Day":"13"},"Article":{"@attributes":{"PubModel":"Electronic-eCollection"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Print"},"@text":"1664-2392"},"JournalIssue":{"@attributes":{"CitedMedium":"Print"},"Volume":"17","PubDate":{"Year":"2026"}},"Title":"Frontiers in endocrinology","ISOAbbreviation":"Front Endocrinol (Lausanne)"},"ArticleTitle":"Effects of non-pharmacological interventions on ulcer healing in patients with diabetic foot: a network meta-analysis of randomized controlled trials.","Pagination":{"StartPage":"1811595","MedlinePgn":"1811595"},"ELocationID":[{"@attributes":{"EIdType":"pii","ValidYN":"Y"},"@text":"1811595"},{"@attributes":{"EIdType":"doi","ValidYN":"Y"},"@text":"10.3389\/fendo.2026.1811595"}],"Abstract":{"AbstractText":[{"@attributes":{"Label":"BACKGROUND","NlmCategory":"UNASSIGNED"},"@text":"Diabetic Foot Ulcers are a serious complication of diabetes, and the clinical treatment is challenging. In this study, network meta-analysis was used to evaluate the effect of different non-drug interventions on Diabetic Foot Ulcer healing and provide evidence to support clinical decision-making."},{"@attributes":{"Label":"METHODS","NlmCategory":"UNASSIGNED"},"@text":"Data sources: 8 databases, including PubMed, Embase, Cochrane, WOS, CNKI, Wanfang Data, CBM, and VIP, were systematically searched. Literature screening: According to the principle of PICOS, two researchers independently screened. Quality evaluation: Two researchers independently used the Cochrane bias risk assessment tool (RoB 2.0) to evaluate the risk of bias. Statistical analysis: by NMA of the random effects model under the framework of frequency."},{"@attributes":{"Label":"RESULTS","NlmCategory":"UNASSIGNED"},"@text":"A total of 24 randomized controlled trials involving 15 types of interventions were included. The overall quality of the included literature was moderate. The results of NMA showed that Negative Pressure Wound Therapy + Standard Care had the best effect on 12-week healing rate. Compared with Standard Care, Gas Therapy+ Dressing Therapy + Standard Care had the best healing time."},{"@attributes":{"Label":"CONCLUSION","NlmCategory":"UNASSIGNED"},"@text":"Negative Pressure Wound Therapy + Standard Care may be more beneficial for improving the 12-week healing rate of Diabetic Foot Ulcer, while Gas Therapy + Dressing Therapy + Standard Care may show potential advantages in shortening healing time. However, these results rely on a limited number of small-sample studies with wide confidence intervals, indicating limited certainty of evidence. Consequently, the SUCRA rankings should be interpreted with caution as they are primarily exploratory; further high-quality RCTs are required to confirm these findings."},{"@attributes":{"Label":"SYSTEMATIC REVIEW REGISTRATION","NlmCategory":"UNASSIGNED"},"@text":"https:\/\/www.crd.york.ac.uk\/prospero\/, identifier CRD420251122143."}],"CopyrightInformation":"Copyright \u00a9 2026 Zheng, Xie, Wu, Xu, Lin and Dong."},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Zheng","ForeName":"Jiaxing","Initials":"J","AffiliationInfo":[{"Affiliation":"The Second Affiliated Hospital of Shantou University Medical College, Shantou,\u00a0China."},{"Affiliation":"Shantou University Medical College, Shantou,\u00a0China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Xie","ForeName":"Danna","Initials":"D","AffiliationInfo":[{"Affiliation":"The Second Affiliated Hospital of Shantou University Medical College, Shantou,\u00a0China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Wu","ForeName":"Minyu","Initials":"M","AffiliationInfo":[{"Affiliation":"The Second Affiliated Hospital of Shantou University Medical College, Shantou,\u00a0China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Xu","ForeName":"Hongtao","Initials":"H","AffiliationInfo":[{"Affiliation":"The Second Affiliated Hospital of Shantou University Medical College, Shantou,\u00a0China."},{"Affiliation":"Shantou University Medical College, Shantou,\u00a0China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Lin","ForeName":"Siyin","Initials":"S","AffiliationInfo":[{"Affiliation":"Shantou University Medical College, Shantou,\u00a0China."},{"Affiliation":"Shantou University Medical College Cancer Hospital, Shantou,\u00a0China."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Dong","ForeName":"Lili","Initials":"L","AffiliationInfo":[{"Affiliation":"The Second Affiliated Hospital of Shantou University Medical College, Shantou,\u00a0China."}]}]},"Language":["eng"],"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D017418"},"@text":"Meta-Analysis"},{"@attributes":{"UI":"D000078182"},"@text":"Systematic Review"}]},"ArticleDate":[{"@attributes":{"DateType":"Electronic"},"Year":"2026","Month":"03","Day":"26"}]},"MedlineJournalInfo":{"Country":"Switzerland","MedlineTA":"Front Endocrinol (Lausanne)","NlmUniqueID":"101555782","ISSNLinking":"1664-2392"},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D006801","MajorTopicYN":"N"},"@text":"Humans"}},{"DescriptorName":{"@attributes":{"UI":"D017719","MajorTopicYN":"Y"},"@text":"Diabetic Foot"},"QualifierName":[{"@attributes":{"UI":"Q000628","MajorTopicYN":"N"},"@text":"therapy"}]},{"DescriptorName":{"@attributes":{"UI":"D016032","MajorTopicYN":"N"},"@text":"Randomized Controlled Trials as Topic"}},{"DescriptorName":{"@attributes":{"UI":"D014945","MajorTopicYN":"Y"},"@text":"Wound Healing"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"N"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D000071076","MajorTopicYN":"N"},"@text":"Network Meta-Analysis as Topic"}}]},"KeywordList":[{"@attributes":{"Owner":"NOTNLM"},"Keyword":[{"@attributes":{"MajorTopicYN":"N"},"@text":"diabetic foot ulcer"},{"@attributes":{"MajorTopicYN":"N"},"@text":"healing rate"},{"@attributes":{"MajorTopicYN":"N"},"@text":"healing time"},{"@attributes":{"MajorTopicYN":"N"},"@text":"network meta-analysis"},{"@attributes":{"MajorTopicYN":"N"},"@text":"non-pharmacological intervention"},{"@attributes":{"MajorTopicYN":"N"},"@text":"nursing"},{"@attributes":{"MajorTopicYN":"N"},"@text":"wound care"}]}],"CoiStatement":"The author(s) declared that this work was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest."},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"received"},"Year":"2026","Month":"2","Day":"15"},{"@attributes":{"PubStatus":"revised"},"Year":"2026","Month":"3","Day":"6"},{"@attributes":{"PubStatus":"accepted"},"Year":"2026","Month":"3","Day":"10"},{"@attributes":{"PubStatus":"medline"},"Year":"2026","Month":"4","Day":"13","Hour":"18","Minute":"18"},{"@attributes":{"PubStatus":"pubmed"},"Year":"2026","Month":"4","Day":"13","Hour":"18","Minute":"17"},{"@attributes":{"PubStatus":"entrez"},"Year":"2026","Month":"4","Day":"13","Hour":"6","Minute":"37"},{"@attributes":{"PubStatus":"pmc-release"},"Year":"2026","Month":"3","Day":"26"}]},"PublicationStatus":"epublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"41970969"},{"@attributes":{"IdType":"pmc"},"@text":"PMC13061723"},{"@attributes":{"IdType":"doi"},"@text":"10.3389\/fendo.2026.1811595"}]},"ReferenceList":[{"Reference":[{"Citation":"GBD 2021 Diabetes Collaborators . Global, regional, and national burden of diabetes from 1990 to 2021, with projections of prevalence to 2050: a systematic analysis for the Global Burden of Disease Study 2021. LANCET. (2023) 402:203\u201334. doi:\u00a0 10.1016\/S0140-6736(23)01301-6, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/S0140-6736(23)01301-6"},{"@attributes":{"IdType":"pmc"},"@text":"PMC10364581"},{"@attributes":{"IdType":"pubmed"},"@text":"37356446"}]}},{"Citation":"Dawi J, Tumanyan K, Tomas K, Misakyan Y, Gargaloyan A, Gonzalez E, et al. Diabetic foot ulcers: pathophysiology, immune dysregulation, and emerging therapeutic strategies. BIOMEDICINES. (2025) 13:1076. doi:\u00a0 10.3390\/biomedicines13051076, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.3390\/biomedicines13051076"},{"@attributes":{"IdType":"pmc"},"@text":"PMC12109115"},{"@attributes":{"IdType":"pubmed"},"@text":"40426903"}]}},{"Citation":"Lin C, Tian J, Zhang Z, Zheng C, Liu J. Risk factors associated with the recurrence of diabetic foot ulcers: A meta-analysis. PloS One. (2025) 20:e318216. doi:\u00a0 10.1371\/journal.pone.0318216, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1371\/journal.pone.0318216"},{"@attributes":{"IdType":"pmc"},"@text":"PMC11828396"},{"@attributes":{"IdType":"pubmed"},"@text":"39951451"}]}},{"Citation":"Everett E, Mathioudakis N. Update on management of diabetic foot ulcers. Ann NY Acad Sci. (2018) 1411:153\u201365. doi:\u00a0 10.1111\/nyas.13569, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1111\/nyas.13569"},{"@attributes":{"IdType":"pmc"},"@text":"PMC5793889"},{"@attributes":{"IdType":"pubmed"},"@text":"29377202"}]}},{"Citation":"van Netten JJ, Raspovic A, Lavery LA, Monteiro-Soares M, Paton J, Rasmussen A. Prevention of foot ulcers in persons with diabetes at risk of ulceration: A systematic review and meta-analysis. DIABETES-METAB Res. (2024) 40:e3652. doi:\u00a0 10.1002\/dmrr.3652, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1002\/dmrr.3652"},{"@attributes":{"IdType":"pubmed"},"@text":"37243880"}]}},{"Citation":"McDermott K, Fang M, Boulton AJM, et al. Etiology, epidemiology, and disparities in the burden of diabetic foot ulcers. Diabetes Care. (2023) 46:209\u201321. doi:\u00a0 10.2337\/dci22-0043, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.2337\/dci22-0043"},{"@attributes":{"IdType":"pmc"},"@text":"PMC9797649"},{"@attributes":{"IdType":"pubmed"},"@text":"36548709"}]}},{"Citation":"Armstrong DG, Tan T, Boulton AJM, Bus SA. Diabetic foot ulcers: A review. JAMA-J Am Med Assoc. (2023) 330:62\u201375. doi:\u00a0 10.1001\/jama.2023.10578, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1001\/jama.2023.10578"},{"@attributes":{"IdType":"pmc"},"@text":"PMC10723802"},{"@attributes":{"IdType":"pubmed"},"@text":"37395769"}]}},{"Citation":"Lo ZJ, Surendra NK, Saxena A, Car J. Clinical and economic burden of diabetic foot ulcers: A 5-year longitudinal multi-ethnic cohort study from the tropics. Int Wound J. (2021) 18:375\u201386. doi:\u00a0 10.1111\/iwj.13540, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1111\/iwj.13540"},{"@attributes":{"IdType":"pmc"},"@text":"PMC8244009"},{"@attributes":{"IdType":"pubmed"},"@text":"33497545"}]}},{"Citation":"Wang Y, Wang C, Zheng L. Bibliometric analysis of systematic review and meta-analysis on diabetic foot ulcer. HELIYON. (2024) 10:e27534. doi:\u00a0 10.1016\/j.heliyon.2024.e27534, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.heliyon.2024.e27534"},{"@attributes":{"IdType":"pmc"},"@text":"PMC10944227"},{"@attributes":{"IdType":"pubmed"},"@text":"38496839"}]}},{"Citation":"Hashempour R, MirHashemi S, Mollajafari F, Damiri S, ArabAhmadi A, Raei B. Economic burden of diabetic foot ulcer: a case of Iran. BMC Health Serv Res. (2024) 24:363. doi:\u00a0 10.1186\/s12913-024-10873-9, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1186\/s12913-024-10873-9"},{"@attributes":{"IdType":"pmc"},"@text":"PMC10958898"},{"@attributes":{"IdType":"pubmed"},"@text":"38515182"}]}},{"Citation":"Jiang P, Li Q, Luo Y, Luo F, Che Q, Lu Z, et al. Current status and progress in research on dressing management for diabetic foot ulcer. Front Endocrinol. (2023) 14:1221705. doi:\u00a0 10.3389\/fendo.2023.1221705, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.3389\/fendo.2023.1221705"},{"@attributes":{"IdType":"pmc"},"@text":"PMC10470649"},{"@attributes":{"IdType":"pubmed"},"@text":"37664860"}]}},{"Citation":"Clavel S, Denizot C, Bo\u00ebzennec B, Turzi A, Albache N. A randomised controlled clinical study comparing the efficacy and safety of an autologous standardised leukocyte-poor platelet gel with standard care for the treatment of chronic neuropathic diabetic foot ulcers. Int Wound J. (2025) 22:e70495. doi:\u00a0 10.1111\/iwj.70495, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1111\/iwj.70495"},{"@attributes":{"IdType":"pmc"},"@text":"PMC12003047"},{"@attributes":{"IdType":"pubmed"},"@text":"40240289"}]}},{"Citation":"Parks VE, Crisologo P, Lavery LA, Banks J, Liette MD, Johnson L, et al. 39-LB: progress in diabetic foot ulcer healing with standard of care therapy alone: A meta-analysis. DIABETES. (2020) 69:39. doi:\u00a0 10.2337\/db20-39-LB, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.2337\/db20-39-LB"}]}},{"Citation":"Coye TL, Bargas Ochoa M, Zulbaran-Rojas A, Martinez Leal B, Quattas A, Tarricone A. Healing of diabetic neuropathic foot ulcers receiving standard treatment in randomised controlled trials: A random effects meta-analysis. Wound Repair Regener. (2025) 33:e13237. doi:\u00a0 10.1111\/wrr.13237, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1111\/wrr.13237"},{"@attributes":{"IdType":"pubmed"},"@text":"39654287"}]}},{"Citation":"Armstrong DG, Orgill DP, Galiano R, Glat PM, Didomenico L, Sopko NA, et al. A multicenter, randomized controlled clinical trial evaluating the effects of a novel autologous heterogeneous skin construct in the treatment of Wagner one diabetic foot ulcers: Final analysis. Int Wound J. (2023) 20:4083\u201396. doi:\u00a0 10.1111\/iwj.14301, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1111\/iwj.14301"},{"@attributes":{"IdType":"pmc"},"@text":"PMC10681466"},{"@attributes":{"IdType":"pubmed"},"@text":"37402533"}]}},{"Citation":"Niami F, Molavynejad S, Hemmati AA, Bijan Nejad D, Yazdanpanah L, Shakiba Maram N, et al. Evaluation of the effect of a gel made with amniotic fluid formulation on the healing of diabetic foot ulcers: A triple-blind clinical trial. Front Public Health. (2022) 10:1025391. doi:\u00a0 10.3389\/fpubh.2022.1025391, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.3389\/fpubh.2022.1025391"},{"@attributes":{"IdType":"pmc"},"@text":"PMC9798771"},{"@attributes":{"IdType":"pubmed"},"@text":"36589960"}]}},{"Citation":"Wainstein J, Feldbrin Z, Boaz M, Harman-Boehm I. Efficacy of ozone-oxygen therapy for the treatment of diabetic foot ulcers. Diabetes Technol THE. (2011) 13:1255\u201360. doi:\u00a0 10.1089\/dia.2011.0018, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1089\/dia.2011.0018"},{"@attributes":{"IdType":"pubmed"},"@text":"21751891"}]}},{"Citation":"You HJ, Han SK, Rhie JW. Randomised controlled clinical trial for autologous fibroblast-hyaluronic acid complex in treating diabetic foot ulcers. J Wound Care. (2014) 23:521\u20132, 524, 526-30. doi:\u00a0 10.12968\/jowc.2014.23.11.521, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.12968\/jowc.2014.23.11.521"},{"@attributes":{"IdType":"pubmed"},"@text":"25375400"}]}},{"Citation":"Alvarez O, Patel M, Rogers R, Booker J. Effect of non-contact normothermic wound therapy on the healing of diabetic neuropathic foot ulcers. J Tissue VIABILITY. (2006) 16:8\u201311. doi:\u00a0 10.1016\/S0965-206X(06)61002-4, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/S0965-206X(06)61002-4"},{"@attributes":{"IdType":"pubmed"},"@text":"16494276"}]}},{"Citation":"Snyder R, Galiano R, Mayer P, Rogers LC, Alvarez O, Sanuwave Trial Investigators . Diabetic foot ulcer treatment with focused shockwave therapy: two multicentre, prospective, controlled, double-blinded, randomised phase III clinical trials. J Wound Care. (2018) 27:822\u201336. doi:\u00a0 10.12968\/jowc.2018.27.12.822, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.12968\/jowc.2018.27.12.822"},{"@attributes":{"IdType":"pubmed"},"@text":"30557108"}]}},{"Citation":"Driver VR, Reyzelman A, Kawalec J, French M. A prospective, randomized, blinded, controlled trial comparing transdermal continuous oxygen delivery to moist wound therapy for the treatment of diabetic foot ulcers. Ostomy Wound Manage. (2017) 63:12\u201328.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"28448266"}]}},{"Citation":"Niederauer MQ, Michalek JE, Liu Q, Papas KK, Lavery LA, Armstrong DG. Continuous diffusion of oxygen improves diabetic foot ulcer healing when compared with a placebo control: a randomised, double-blind, multicentre study. J Wound Care. (2018) 27:S30\u201345. doi:\u00a0 10.12968\/jowc.2018.27.Sup9.S30, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.12968\/jowc.2018.27.Sup9.S30"},{"@attributes":{"IdType":"pubmed"},"@text":"30207844"}]}},{"Citation":"Fedorko L, Bowen JM, Jones W, Oreopoulos G, Goeree R, Hopkins RB, et al. Hyperbaric oxygen therapy does not reduce indications for amputation in patients with diabetes with nonhealing ulcers of the lower limb: A prospective, double-blind, randomized controlled clinical trial. Diabetes Care. (2016) 39:392\u20139. doi:\u00a0 10.2337\/dc15-2001, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.2337\/dc15-2001"},{"@attributes":{"IdType":"pubmed"},"@text":"26740639"}]}},{"Citation":"L\u00f6ndahl M, Katzman P, Nilsson A, Hammarlund C. Hyperbaric oxygen therapy facilitates healing of chronic foot ulcers in patients with diabetes. Diabetes Care. (2010) 33:998\u20131003. doi:\u00a0 10.2337\/dc09-1754, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.2337\/dc09-1754"},{"@attributes":{"IdType":"pmc"},"@text":"PMC2858204"},{"@attributes":{"IdType":"pubmed"},"@text":"20427683"}]}},{"Citation":"Liakos A, Liakopoulou P, Tsapas A. Cyclical pressurized topical wound oxygen therapy increased healing of refractory diabetic foot ulcers. Annals of Internal Medicine. (2020) 172:JC27. doi:\u00a0 10.7326\/ACPJ202003170-027, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.7326\/ACPJ202003170-027"},{"@attributes":{"IdType":"pubmed"},"@text":"32176893"}]}},{"Citation":"Ennis WJ, Foremann P, Mozen N, Massey J, Conner-Kerr T, Meneses P. Ultrasound therapy for recalcitrant diabetic foot ulcers: results of a randomized, double-blind, controlled, multicenter study. Ostomy Wound Manage. (2005) 51:24\u201339.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"16234574"}]}},{"Citation":"Jeffcoate W, Game F, Turtle-Savage V, Musgrove A, Price P, Tan W. Evaluation of the effectiveness and cost-effectiveness of lightweight fibreglass heel casts in the management of ulcers of the heel in diabetes: a randomised controlled trial. Health Technol ASSES. (2017) 21:1\u201392. doi:\u00a0 10.3310\/hta21340, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.3310\/hta21340"},{"@attributes":{"IdType":"pmc"},"@text":"PMC5502374"},{"@attributes":{"IdType":"pubmed"},"@text":"28644115"}]}},{"Citation":"Snyder R, Nouvong A, Ulloa J, Wahab N, Treadwell T, Bruwer F. Efficacy and safety of autologous whole blood clot in diabetic foot ulcers: a randomised controlled trial. J Wound Care. (2024) 33:688\u2013700. doi:\u00a0 10.12968\/jowc.2024.0195, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.12968\/jowc.2024.0195"},{"@attributes":{"IdType":"pubmed"},"@text":"39287414"}]}},{"Citation":"Chen C-Y, Wu R-W, Hsu M-C, Hsieh C-J, Chou M-C. Adjunctive hyperbaric oxygen therapy for healing of chronic diabetic foot ulcers: A randomized controlled trial. J Wound OSTOMY CONT. (2017) 44:536\u201345. doi:\u00a0 10.1097\/WON.0000000000000374, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1097\/WON.0000000000000374"},{"@attributes":{"IdType":"pubmed"},"@text":"28968346"}]}},{"Citation":"Gould LJ, Orgill DP, Armstrong DG, Galiano RD, Glat PM, Zelen CM, et al. Improved healing of chronic diabetic foot wounds in a prospective randomised controlled multi-centre clinical trial with a microvascular tissue allograft. Int Wound J. (2022) 19:811\u201325. doi:\u00a0 10.1111\/iwj.13679, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1111\/iwj.13679"},{"@attributes":{"IdType":"pmc"},"@text":"PMC9013595"},{"@attributes":{"IdType":"pubmed"},"@text":"34469077"}]}},{"Citation":"Armstrong DG, Nguyen HC. Improvement in healing with aggressive edema reduction after debridement of foot infection in persons with diabetes. Arch Surg. (2000) 135:1405\u20139. doi:\u00a0 10.1001\/archsurg.135.12.1405, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1001\/archsurg.135.12.1405"},{"@attributes":{"IdType":"pubmed"},"@text":"11115342"}]}},{"Citation":"Shetty R, Giridhar BS, Potphode A. Role of ultrathin skin graft in early healing of diabetic foot ulcers: a randomized controlled trial in comparison with conventional methods. WOUNDS. (2022) 33:57\u201367. doi:\u00a0 10.25270\/wnds\/2022.5767, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.25270\/wnds\/2022.5767"},{"@attributes":{"IdType":"pubmed"},"@text":"35108670"}]}},{"Citation":"Maranna H, Lal P, Mishra A, Bains L, Sawant G, Bhatia R, et al. Negative pressure wound therapy in grade 1 and 2 diabetic foot ulcers: A randomized controlled study. Diabetes Metab SYND. (2021) 15:365\u201371. doi:\u00a0 10.1016\/j.dsx.2021.01.014, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.dsx.2021.01.014"},{"@attributes":{"IdType":"pubmed"},"@text":"33524646"}]}},{"Citation":"Lantis JC, II, Lullove EJ, Liden B, McEneaney P, Raphael A, Klein R, et al. Final efficacy and cost analysis of a fish skin graft vs standard of care in the management of chronic diabetic foot ulcers: a prospective, multicenter, randomized controlled clinical trial. WOUNDS. (2023) 35:71\u20139. doi:\u00a0 10.25270\/wnds\/22094, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.25270\/wnds\/22094"},{"@attributes":{"IdType":"pubmed"},"@text":"37023475"}]}},{"Citation":"Martinez-De Jes\u00fas FR, Frykberg R, Zambrano-Loaiza E, Jude EB. Re-epithelialization of neuropathic diabetic foot wounds with the use of cryopreserved allografts of human epidermal keratinocyte cultures (Epifast). J Clin Med. (2022) 11:7348. doi:\u00a0 10.3390\/jcm11247348, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.3390\/jcm11247348"},{"@attributes":{"IdType":"pmc"},"@text":"PMC9780794"},{"@attributes":{"IdType":"pubmed"},"@text":"36555962"}]}},{"Citation":"Nayak D, Ray R, Anand C, Dutta Baruah T, Goyal A. Protocolized foot exercises help in improvement of diabetic foot ulcers and quality of life when added to standard therapy\u2013A randomized clinical trial. Int J LOW EXTR Wound. (2024) 92:483\u201390. doi:\u00a0 10.1177\/15347346241262591, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1177\/15347346241262591"},{"@attributes":{"IdType":"pubmed"},"@text":"39034105"}]}},{"Citation":"James MD, Sureshkumar S, Elamurugan TP, Debasis N, Vijayakumar C, Palanivel C. Comparison of vacuum-assisted closure therapy and conventional dressing on wound healing in patients with diabetic foot ulcer: A randomized controlled trial. Nigerian J surgery: Off Publ Nigerian Surg Res Soc. (2019) 25:14\u201320. doi:\u00a0 10.4103\/njs.NJS_14_18, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.4103\/njs.NJS_14_18"},{"@attributes":{"IdType":"pmc"},"@text":"PMC6452767"},{"@attributes":{"IdType":"pubmed"},"@text":"31007506"}]}},{"Citation":"Lullove EJ, Liden B, Winters C, McEneaney P, Raphael A, Lantis JC, II. A multicenter, blinded, randomized controlled clinical trial evaluating the effect of omega-3-rich fish skin in the treatment of chronic, nonresponsive diabetic foot ulcers. WOUNDS. (2021) 33:169\u201377. doi:\u00a0 10.25270\/wnds\/2021.169177, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.25270\/wnds\/2021.169177"},{"@attributes":{"IdType":"pubmed"},"@text":"33872197"}]}},{"Citation":"Das S, Kumar A, Kumar S, Kumar A, Kumar N, Kumar R. Comparison between topical platelet-rich plasma and normal saline dressing in conjunction with total contact casting in treatment of diabetic foot ulcer \u2013 A randomised control trial. Indian Journal of Physical Medicine and Rehabilitation. (2024) 34:212\u20137. doi:\u00a0 10.4103\/ijpmr.ijpmr_43_24","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.4103\/ijpmr.ijpmr_43_24"}]}},{"Citation":"Eraydin \u015e, Av\u015far G. The effect of foot exercises on wound healing in type 2 diabetic patients with a foot ulcer: A randomized controlled study. J Wound OSTOMY CONT. (2018) 45:123\u201330. doi:\u00a0 10.1097\/WON.0000000000000405, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1097\/WON.0000000000000405"},{"@attributes":{"IdType":"pubmed"},"@text":"29521922"}]}},{"Citation":"Esmael HFA, El Basiouny MS, Morsy MI, Abdel Gawad HAES, Hssein AA, Abdallah TE. The effect of combined 650 nm and infrared laser on chronic diabetic foot ulcer surface area: A randomized controlled trial. J Pharm NEGAT RESULT. (2023) 14:199\u2013207."},{"Citation":"Serena TE, Bullock NM, Cole W, Lantis J, Li L, Moore S, et al. Topical oxygen therapy in the treatment of diabetic foot ulcers: a multicentre, open, randomised controlled clinical trial. J Wound Care. (2021) 30:S7\u201314. doi:\u00a0 10.12968\/jowc.2021.30.Sup5.S7, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.12968\/jowc.2021.30.Sup5.S7"},{"@attributes":{"IdType":"pubmed"},"@text":"33979229"}]}},{"Citation":"He S, Liang C, Yi C, Wu M. Therapeutic effect of continuous diffusion of oxygen therapy combined with traditional moist wound dressing therapy in the treatment of diabetic foot ulcers. Diabetes Res Clin PR. (2021) 174:108743. doi:\u00a0 10.1016\/j.diabres.2021.108743, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.diabres.2021.108743"},{"@attributes":{"IdType":"pubmed"},"@text":"33713718"}]}},{"Citation":"Lantis JC, Snyder R, Reyzelman AM, Van Gils CC, Sigal F, Vayser D, et al. Fetal bovine acellular dermal matrix for the closure of diabetic foot ulcers: a prospective randomised controlled trial. J Wound Care. (2021) 30:S18\u201327. doi:\u00a0 10.12968\/jowc.2021.30.Sup7.S18, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.12968\/jowc.2021.30.Sup7.S18"},{"@attributes":{"IdType":"pubmed"},"@text":"34256588"}]}},{"Citation":"Qin X, Wang J. Clinical study on local injection of autologous platelet-rich plasma in the treatment of diabetic foot ulcers. Chin J Reparative Reconstructive Surg. (2019) 33:1547\u201351. doi:\u00a0 10.7507\/1002-1892.201905124, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.7507\/1002-1892.201905124"},{"@attributes":{"IdType":"pmc"},"@text":"PMC8355805"},{"@attributes":{"IdType":"pubmed"},"@text":"31823556"}]}},{"Citation":"Nik Hisamuddin NAR, Wan Mohd Zahiruddin WN, Mohd Yazid B, Rahmah S. Use of hyperbaric oxygen therapy (HBOT) in chronic diabetic wound - A randomised trial. Med J Malaysia. (2019) 74:418\u201324.","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"31649219"}]}},{"Citation":"Dalmedico MM, Do Rocio Fedalto A, Martins WA, de Carvalho CKL, Fernandes BL, Ioshii SO. Effectiveness of negative pressure wound therapy in treating diabetic foot ulcers: a systematic review and meta-analysis of randomized controlled trials. WOUNDS. (2024) 36:281\u20139. doi:\u00a0 10.25270\/wnds\/23140, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.25270\/wnds\/23140"},{"@attributes":{"IdType":"pubmed"},"@text":"39241769"}]}},{"Citation":"Chen L, Zhang S, Da J, Wu W, Ma F, Tang C, et al. A systematic review and meta-analysis of efficacy and safety of negative pressure wound therapy in the treatment of diabetic foot ulcer. Ann PALLIAT Med. (2021) 10:10830\u20139. doi:\u00a0 10.21037\/apm-21-2476, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.21037\/apm-21-2476"},{"@attributes":{"IdType":"pubmed"},"@text":"34763444"}]}},{"Citation":"Yang J, Ning P, Huang J, Ouyang H, Zhang J, Yang F, et al. Comparative efficacy of gas therapy for diabetic foot ulcers using network meta-analysis. PEERJ. (2025) 13:e19571. doi:\u00a0 10.7717\/peerj.19571, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.7717\/peerj.19571"},{"@attributes":{"IdType":"pmc"},"@text":"PMC12178245"},{"@attributes":{"IdType":"pubmed"},"@text":"40538733"}]}},{"Citation":"OuYang H, Yang J, Wan H, Huang J, Yin Y. Effects of different treatment measures on the efficacy of diabetic foot ulcers: a network meta-analysis. Front Endocrinol. (2024) 15:1452192. doi:\u00a0 10.3389\/fendo.2024.1452192, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.3389\/fendo.2024.1452192"},{"@attributes":{"IdType":"pmc"},"@text":"PMC11456420"},{"@attributes":{"IdType":"pubmed"},"@text":"39377075"}]}},{"Citation":"Hu X, Meng H, Liang J, An H, Zhou J, Gao Y, et al. Comparison of the efficacy of 12 interventions in the treatment of diabetic foot ulcers: a network meta-analysis. PEERJ. (2025) 13:e19809. doi:\u00a0 10.7717\/peerj.19809, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.7717\/peerj.19809"},{"@attributes":{"IdType":"pmc"},"@text":"PMC12352421"},{"@attributes":{"IdType":"pubmed"},"@text":"40821981"}]}},{"Citation":"Tian J, Yao G, Tian T, Li X, Li S, Wu C, et al. Comparison of the efficacy and safety of different growth factors in the treatment of diabetic foot ulcers: an updated network meta-analysis. Front Endocrinol. (2025) 16:1614597. doi:\u00a0 10.3389\/fendo.2025.1614597, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.3389\/fendo.2025.1614597"},{"@attributes":{"IdType":"pmc"},"@text":"PMC12237656"},{"@attributes":{"IdType":"pubmed"},"@text":"40636711"}]}},{"Citation":"Chen AC, Lu Y, Hsieh C, Chen YS, Chang KC, Chang DH. Advanced biomaterials and topical medications for treating diabetic foot ulcers: A systematic review and network meta-analysis. Adv Wound Care. (2024) 13:97\u2013113. doi:\u00a0 10.1089\/wound.2023.0024, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1089\/wound.2023.0024"},{"@attributes":{"IdType":"pubmed"},"@text":"37395488"}]}},{"Citation":"Zhou X, Chen S, Savitz B, Yu N, Perdikis G, Duckworth K, et al. Comparative efficacy of different functional hydrogel dressings in healing diabetic foot ulcer: A systematic review and network meta-analysis. Diabetes Obes Metab. (2025) 27:3431\u201341. doi:\u00a0 10.1111\/dom.16367, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1111\/dom.16367"},{"@attributes":{"IdType":"pubmed"},"@text":"40197692"}]}},{"Citation":"Ning P, Liu Y, Kang J, Cao H, Zhang J. Comparison of healing effectiveness of different debridement approaches for diabetic foot ulcers: a network meta-analysis of randomized controlled trials. Front Public Health. (2023) 11:1271706. doi:\u00a0 10.3389\/fpubh.2023.1271706, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.3389\/fpubh.2023.1271706"},{"@attributes":{"IdType":"pmc"},"@text":"PMC10749485"},{"@attributes":{"IdType":"pubmed"},"@text":"38146472"}]}},{"Citation":"Yang H-A, Hsu R-J, Jheng W-L, Weng F-J, Lee J-J. Comparative efficacy of regenerative therapies for diabetic foot ulcers: A network meta-analysis. Ann PLAS Surg. (2025) 94:S24\u201332. doi:\u00a0 10.1097\/SAP.0000000000004192, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1097\/SAP.0000000000004192"},{"@attributes":{"IdType":"pubmed"},"@text":"39996539"}]}},{"Citation":"Yelland AC, Meace C, Knighton P, Holman N, Wild SH, Michalowski J, et al. Impact of case-mix adjustment on observed variation in the healing of diabetic foot ulcers at 12\u2009weeks using data from the National Diabetes Foot Care Audit of England and Wales: A cohort study. Diabetic Med. (2023) 40:e14959. doi:\u00a0 10.1111\/dme.14959, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1111\/dme.14959"},{"@attributes":{"IdType":"pubmed"},"@text":"36114737"}]}},{"Citation":"Thomason G, Gooday C, Nunney I, Dhatariya K. The association of hbA(1c) variability with 12 week and 12 month outcomes on diabetes related foot ulcer healing. Diabetes Ther. (2024) 15:2223\u201332. doi:\u00a0 10.1007\/s13300-024-01640-4, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1007\/s13300-024-01640-4"},{"@attributes":{"IdType":"pmc"},"@text":"PMC11411040"},{"@attributes":{"IdType":"pubmed"},"@text":"39153153"}]}},{"Citation":"Hutton B, Salanti G, Caldwell DM, Chaimani A, Schmid CH, Cameron C, et al. The PRISMA extension statement for reporting of systematic reviews incorporating network meta-analyses of health care interventions: checklist and explanations. Ann Intern Med. (2015) 162:777\u201384. doi:\u00a0 10.7326\/M14-2385, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.7326\/M14-2385"},{"@attributes":{"IdType":"pubmed"},"@text":"26030634"}]}},{"Citation":"Liberati A, Altman DG, Tetzlaff J, Mulrow C, G\u00f8tzsche PC, Ioannidis JPA, et al. The PRISMA statement for reporting systematic reviews and meta-analyses of studies that evaluate health care interventions: explanation and elaboration. J Clin Epidemiol. (2009) 62:e1\u201334. doi:\u00a0 10.1016\/j.jclinepi.2009.06.006, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.jclinepi.2009.06.006"},{"@attributes":{"IdType":"pubmed"},"@text":"19631507"}]}},{"Citation":"Chen P, Vilorio CN, Dhatariya K, Jeffcoate W, Lobmann R, McIntosh C, et al. Guidelines on interventions to enhance healing of foot ulcers in people with diabetes (IWGDF 2023 update). Diabetes Metab Res Rev. (2023) 39:e3644. doi:\u00a0 10.1002\/dmrr.3644, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1002\/dmrr.3644"},{"@attributes":{"IdType":"pubmed"},"@text":"37232034"}]}},{"Citation":"Moore THM, Higgins JPT, Dwan K. Ten tips for successful assessment of risk of bias in randomized trials using the RoB 2 tool: Early lessons from Cochrane. Cochrane Evid Synth Methods. (2023) 1:e12031. doi:\u00a0 10.1002\/cesm.12031, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1002\/cesm.12031"},{"@attributes":{"IdType":"pmc"},"@text":"PMC11795937"},{"@attributes":{"IdType":"pubmed"},"@text":"40476008"}]}},{"Citation":"Higgins JPT, Thompson SG. Quantifying heterogeneity in a meta-analysis. Stat Med. (2002) 21:1539\u201358. doi:\u00a0 10.1002\/sim.1186, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1002\/sim.1186"},{"@attributes":{"IdType":"pubmed"},"@text":"12111919"}]}},{"Citation":"Greco T, Edefonti V, Biondi-Zoccai G, Decarli A, Gasparini M, Zangrillo A, et al. A multilevel approach to network meta-analysis within a frequentist framework. CONTEMP Clin TRIALS. (2015) 42:51\u20139. doi:\u00a0 10.1016\/j.cct.2015.03.005, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1016\/j.cct.2015.03.005"},{"@attributes":{"IdType":"pubmed"},"@text":"25804722"}]}},{"Citation":"Xia C, Zheng Y, Ji L, Liu H. Comparative effectiveness of different interventions on adherence to exercise-based CR among patients after percutaneous coronary intervention: a network meta-analysis of randomized controlled trials. BMC Nurs. (2024) 23:897. doi:\u00a0 10.1186\/s12912-024-02561-0, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1186\/s12912-024-02561-0"},{"@attributes":{"IdType":"pmc"},"@text":"PMC11657924"},{"@attributes":{"IdType":"pubmed"},"@text":"39695575"}]}},{"Citation":"Higgins JPT, Thompson SG, Deeks JJ, Altman DG. Measuring inconsistency in meta-analyses. BMJ-BRIT Med J. (2003) 327:557\u201360. doi:\u00a0 10.1136\/bmj.327.7414.557, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1136\/bmj.327.7414.557"},{"@attributes":{"IdType":"pmc"},"@text":"PMC192859"},{"@attributes":{"IdType":"pubmed"},"@text":"12958120"}]}},{"Citation":"Chaimani A, Higgins JPT, Mavridis D, Spyridonos P, Salanti G. Graphical tools for network meta-analysis in STATA. PloS One. (2013) 8:e76654. doi:\u00a0 10.1371\/journal.pone.0076654, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1371\/journal.pone.0076654"},{"@attributes":{"IdType":"pmc"},"@text":"PMC3789683"},{"@attributes":{"IdType":"pubmed"},"@text":"24098547"}]}},{"Citation":"Egger M, Davey Smith G, Schneider M, Minder C. Bias in meta-analysis detected by a simple, graphical test. BMJ-BRIT Med J. (1997) 315:629\u201334. doi:\u00a0 10.1136\/bmj.315.7109.629, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1136\/bmj.315.7109.629"},{"@attributes":{"IdType":"pmc"},"@text":"PMC2127453"},{"@attributes":{"IdType":"pubmed"},"@text":"9310563"}]}},{"Citation":"Migliavaca CB, Stein C, Colpani V, Barker TH, Ziegelmann PK, Munn Z, et al. Meta-analysis of prevalence: I(2) statistic and how to deal with heterogeneity. Res SYNTH Methods. (2022) 13:363\u20137. doi:\u00a0 10.1002\/jrsm.1547, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.1002\/jrsm.1547"},{"@attributes":{"IdType":"pubmed"},"@text":"35088937"}]}},{"Citation":"Liu S, He CZ, Cai YT, Xing QP, Guo YZ, Chen ZL, et al. Evaluation of negative-pressure wound therapy for patients with diabetic foot ulcers: systematic review and meta-analysis. THE Clin Risk MANAG. (2017) 13:533\u201344. doi:\u00a0 10.2147\/TCRM.S131193, PMID:","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"doi"},"@text":"10.2147\/TCRM.S131193"},{"@attributes":{"IdType":"pmc"},"@text":"PMC5403129"},{"@attributes":{"IdType":"pubmed"},"@text":"28458556"}]}}]}]}}}