{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"7903253"},"DateCompleted":{"Year":"1994","Month":"01","Day":"26"},"DateRevised":{"Year":"2019","Month":"06","Day":"21"},"Article":{"@attributes":{"PubModel":"Print"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Print"},"@text":"0014-5793"},"JournalIssue":{"@attributes":{"CitedMedium":"Print"},"Volume":"336","Issue":"1","PubDate":{"Year":"1993","Month":"Dec","Day":"20"}},"Title":"FEBS letters","ISOAbbreviation":"FEBS Lett"},"ArticleTitle":"The HOX complex neighbored by the EVX gene, as well as two other homeobox-containing genes, the GBX-class and the EN-class, are located on the same chromosomes 2 and 7 in humans.","Pagination":{"StartPage":"107","EndPage":"110","MedlinePgn":"107-10"},"Abstract":{"AbstractText":["Two newly identified human homeobox-containing genes, GBX1 and GBX2, are closely related genes, as are members of the other homeobox genes, EN-1 and EN-2. GBX1 and EN-2 have been mapped to chromosome 7q36. The present study shows that GBX2 was mapped to chromosome 2q37. EN-1 was mapped to chromosome 2q14. Moreover, two HOX complexes neighbored by the EVX gene, HOXA and HOXD, are located at chromosome 7p15-p14 and 2q31-q37, respectively. Thus, it is possible that these homeobox genes were linked to each other on an ancestral genome and that the ancestral chromosome segment was duplicated during evolution."]},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Matsui","ForeName":"T","Initials":"T","AffiliationInfo":[{"Affiliation":"Institute for Comprehensive Medical Science, Fujita Health University, Aichi, Japan."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Hirai","ForeName":"M","Initials":"M"},{"@attributes":{"ValidYN":"Y"},"LastName":"Hirano","ForeName":"M","Initials":"M"},{"@attributes":{"ValidYN":"Y"},"LastName":"Kurosawa","ForeName":"Y","Initials":"Y"}]},"Language":["eng"],"DataBankList":{"@attributes":{"CompleteYN":"Y"},"DataBank":[{"DataBankName":"GENBANK","AccessionNumberList":{"AccessionNumber":["U02080"]}}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D013485"},"@text":"Research Support, Non-U.S. Gov't"}]}},"MedlineJournalInfo":{"Country":"England","MedlineTA":"FEBS Lett","NlmUniqueID":"0155157","ISSNLinking":"0014-5793"},"ChemicalList":{"Chemical":[{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D004268"},"@text":"DNA-Binding Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C513076"},"@text":"EN1 protein, human"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C084958"},"@text":"GBX2 protein, human"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C513182"},"@text":"Gbx2 protein, mouse"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D018398"},"@text":"Homeodomain Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D011506"},"@text":"Proteins"}}]},"CitationSubset":["IM"],"GeneSymbolList":{"GeneSymbol":["EN","EVX","GBX2","HOX"]},"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D000595","MajorTopicYN":"N"},"@text":"Amino Acid Sequence"}},{"DescriptorName":{"@attributes":{"UI":"D001483","MajorTopicYN":"N"},"@text":"Base Sequence"}},{"DescriptorName":{"@attributes":{"UI":"D002874","MajorTopicYN":"N"},"@text":"Chromosome Mapping"}},{"DescriptorName":{"@attributes":{"UI":"D002889","MajorTopicYN":"Y"},"@text":"Chromosomes, Human, Pair 2"}},{"DescriptorName":{"@attributes":{"UI":"D002897","MajorTopicYN":"Y"},"@text":"Chromosomes, Human, Pair 7"}},{"DescriptorName":{"@attributes":{"UI":"D004268","MajorTopicYN":"N"},"@text":"DNA-Binding Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D005801","MajorTopicYN":"Y"},"@text":"Genes, Homeobox"}},{"DescriptorName":{"@attributes":{"UI":"D018398","MajorTopicYN":"Y"},"@text":"Homeodomain Proteins"}},{"DescriptorName":{"@attributes":{"UI":"D006801","MajorTopicYN":"N"},"@text":"Humans"}},{"DescriptorName":{"@attributes":{"UI":"D008969","MajorTopicYN":"N"},"@text":"Molecular Sequence Data"}},{"DescriptorName":{"@attributes":{"UI":"D011506","MajorTopicYN":"N"},"@text":"Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D017386","MajorTopicYN":"N"},"@text":"Sequence Homology, Amino Acid"}}]}},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"pubmed"},"Year":"1993","Month":"12","Day":"20"},{"@attributes":{"PubStatus":"medline"},"Year":"1993","Month":"12","Day":"20","Hour":"0","Minute":"1"},{"@attributes":{"PubStatus":"entrez"},"Year":"1993","Month":"12","Day":"20","Hour":"0","Minute":"0"}]},"PublicationStatus":"ppublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"7903253"},{"@attributes":{"IdType":"doi"},"@text":"10.1016\/0014-5793(93)81620-f"},{"@attributes":{"IdType":"pii"},"@text":"0014-5793(93)81620-F"}]}}}}