{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"9346236"},"DateCompleted":{"Year":"1997","Month":"11","Day":"13"},"DateRevised":{"Year":"2019","Month":"12","Day":"10"},"Article":{"@attributes":{"PubModel":"Print"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Print"},"@text":"0092-8674"},"JournalIssue":{"@attributes":{"CitedMedium":"Print"},"Volume":"91","Issue":"2","PubDate":{"Year":"1997","Month":"Oct","Day":"17"}},"Title":"Cell","ISOAbbreviation":"Cell"},"ArticleTitle":"The homeobox gene GBX2, a target of the myb oncogene, mediates autocrine growth and monocyte differentiation.","Pagination":{"StartPage":"185","EndPage":"195","MedlinePgn":"185-95"},"Abstract":{"AbstractText":["The homeobox gene GBX2 was identified as a target gene of the v-Myb oncoprotein encoded by the avian myeloblastosis virus (AMV). GBX2 activation by c-Myb requires signal transduction emanating from the cell surface while the leukemogenic AMV v-Myb constitutively induces the GBX2 gene. Mutations in the DNA binding domain of AMV-Myb render it independent of signaling events and concomitantly abrogate the collaboration between Myb and CCAAT Enhancer Binding Proteins (C\/EBP), which are involved in granulocyte differentiation. Ectopic expression of GBX2 in growth factor-dependent myeloblasts induces monocytic features and independence from exogenous cytokines, reflecting distinct features of AMV-transformed cells. Our results suggest that Myb or factors it interacts with contribute to hematopoietic lineage choice and differentiation in a signal transduction-dependent fashion."]},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Kowenz-Leutz","ForeName":"E","Initials":"E","AffiliationInfo":[{"Affiliation":"Max-Delbr\u00fcck-Centrum for Molecular Medicine, Berlin, Germany."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Herr","ForeName":"P","Initials":"P"},{"@attributes":{"ValidYN":"Y"},"LastName":"Niss","ForeName":"K","Initials":"K"},{"@attributes":{"ValidYN":"Y"},"LastName":"Leutz","ForeName":"A","Initials":"A"}]},"Language":["eng"],"DataBankList":{"@attributes":{"CompleteYN":"Y"},"DataBank":[{"DataBankName":"GENBANK","AccessionNumberList":{"AccessionNumber":["AF022151"]}}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D013485"},"@text":"Research Support, Non-U.S. Gov't"}]}},"MedlineJournalInfo":{"Country":"United States","MedlineTA":"Cell","NlmUniqueID":"0413066","ISSNLinking":"0092-8674"},"ChemicalList":{"Chemical":[{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D030161"},"@text":"Avian Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D016207"},"@text":"Cytokines"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D004268"},"@text":"DNA-Binding Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D006133"},"@text":"Growth Substances"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D018398"},"@text":"Homeodomain Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D036341"},"@text":"Intercellular Signaling Peptides and Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C059626"},"@text":"MGF protein, chicken"}}]},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D019898","MajorTopicYN":"N"},"@text":"Autocrine Communication"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"Y"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D030161","MajorTopicYN":"Y"},"@text":"Avian Proteins"}},{"DescriptorName":{"@attributes":{"UI":"D001854","MajorTopicYN":"N"},"@text":"Bone Marrow Cells"},"QualifierName":[{"@attributes":{"UI":"Q000737","MajorTopicYN":"N"},"@text":"chemistry"},{"@attributes":{"UI":"Q000502","MajorTopicYN":"N"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D002454","MajorTopicYN":"N"},"@text":"Cell Differentiation"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D002645","MajorTopicYN":"N"},"@text":"Chickens"}},{"DescriptorName":{"@attributes":{"UI":"D016207","MajorTopicYN":"N"},"@text":"Cytokines"}},{"DescriptorName":{"@attributes":{"UI":"D004268","MajorTopicYN":"N"},"@text":"DNA-Binding Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"N"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D018507","MajorTopicYN":"N"},"@text":"Gene Expression Regulation, Developmental"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"N"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D006133","MajorTopicYN":"N"},"@text":"Growth Substances"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D006410","MajorTopicYN":"N"},"@text":"Hematopoiesis"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D006412","MajorTopicYN":"N"},"@text":"Hematopoietic Stem Cells"},"QualifierName":[{"@attributes":{"UI":"Q000737","MajorTopicYN":"N"},"@text":"chemistry"},{"@attributes":{"UI":"Q000502","MajorTopicYN":"N"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D018398","MajorTopicYN":"N"},"@text":"Homeodomain Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"},{"@attributes":{"UI":"Q000378","MajorTopicYN":"Y"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D036341","MajorTopicYN":"Y"},"@text":"Intercellular Signaling Peptides and Proteins"}},{"DescriptorName":{"@attributes":{"UI":"D008969","MajorTopicYN":"N"},"@text":"Molecular Sequence Data"}},{"DescriptorName":{"@attributes":{"UI":"D009000","MajorTopicYN":"N"},"@text":"Monocytes"},"QualifierName":[{"@attributes":{"UI":"Q000166","MajorTopicYN":"Y"},"@text":"cytology"}]},{"DescriptorName":{"@attributes":{"UI":"D009857","MajorTopicYN":"N"},"@text":"Oncogenes"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"Y"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D010641","MajorTopicYN":"N"},"@text":"Phenotype"}},{"DescriptorName":{"@attributes":{"UI":"D011401","MajorTopicYN":"N"},"@text":"Promoter Regions, Genetic"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"N"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D015398","MajorTopicYN":"N"},"@text":"Signal Transduction"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D014170","MajorTopicYN":"N"},"@text":"Transformation, Genetic"}}]}},"PubmedData":{"History":{"PubMedPubDate":[{"@attributes":{"PubStatus":"pubmed"},"Year":"1997","Month":"11","Day":"5"},{"@attributes":{"PubStatus":"medline"},"Year":"1997","Month":"11","Day":"5","Hour":"0","Minute":"1"},{"@attributes":{"PubStatus":"entrez"},"Year":"1997","Month":"11","Day":"5","Hour":"0","Minute":"0"}]},"PublicationStatus":"ppublish","ArticleIdList":{"ArticleId":[{"@attributes":{"IdType":"pubmed"},"@text":"9346236"},{"@attributes":{"IdType":"doi"},"@text":"10.1016\/s0092-8674(00)80401-8"},{"@attributes":{"IdType":"pii"},"@text":"S0092-8674(00)80401-8"}]}}}}