{"PubmedArticle":{"MedlineCitation":{"@attributes":{"Status":"MEDLINE","Owner":"NLM","IndexingMethod":"Manual"},"PMID":{"@attributes":{"Version":"1"},"@text":"9427753"},"DateCompleted":{"Year":"1998","Month":"02","Day":"26"},"DateRevised":{"Year":"2026","Month":"01","Day":"28"},"Article":{"@attributes":{"PubModel":"Print"},"Journal":{"ISSN":{"@attributes":{"IssnType":"Print"},"@text":"0261-4189"},"JournalIssue":{"@attributes":{"CitedMedium":"Print"},"Volume":"17","Issue":"1","PubDate":{"Year":"1998","Month":"Jan","Day":"02"}},"Title":"The EMBO journal","ISOAbbreviation":"EMBO J"},"ArticleTitle":"Xiro3 encodes a Xenopus homolog of the Drosophila Iroquois genes and functions in neural specification.","Pagination":{"StartPage":"191","EndPage":"203","MedlinePgn":"191-203"},"Abstract":{"AbstractText":["We have identified in Xenopus and in the mouse two highly related genes, Xiro3 and Irx3 respectively, that encode a Drosophila Iroquois-related homeobox transcription factor. Xiro3 in Xenopus and Irx3 in the mouse are expressed early in the prospective neural plate in a subset of neural precursor cells. In Xenopus, injection of Xiro3 mRNA expands the neural tube and induces ectopic neural tissue in the epidermis, based on the ectopic expression of early neural markers such as Xsox3. In contrast, the differentiation of the early forming primary neurons, as revealed by the expression of the neuronal marker N-tubulin, is prevented by Xiro3 expression. Activation of Xiro3 expression itself requires the combination of a neural inducing (noggin) and a posteriorizing signal (basic fibroblast growth factor). These results suggest that Xiro3 activation constitutes one of the earliest steps in the development of the neural plate and that it functions in the specification of a neural precursor state."]},"AuthorList":{"@attributes":{"CompleteYN":"Y"},"Author":[{"@attributes":{"ValidYN":"Y"},"LastName":"Bellefroid","ForeName":"E J","Initials":"EJ","AffiliationInfo":[{"Affiliation":"Wellcome\/CRC Institute, Tennis Court Road, Cambridge CB2 1QR, UK."}]},{"@attributes":{"ValidYN":"Y"},"LastName":"Kobbe","ForeName":"A","Initials":"A"},{"@attributes":{"ValidYN":"Y"},"LastName":"Gruss","ForeName":"P","Initials":"P"},{"@attributes":{"ValidYN":"Y"},"LastName":"Pieler","ForeName":"T","Initials":"T"},{"@attributes":{"ValidYN":"Y"},"LastName":"Gurdon","ForeName":"J B","Initials":"JB"},{"@attributes":{"ValidYN":"Y"},"LastName":"Papalopulu","ForeName":"N","Initials":"N"}]},"Language":["eng"],"GrantList":{"@attributes":{"CompleteYN":"Y"},"Grant":[{"Agency":"Wellcome Trust","Country":"United Kingdom"}]},"PublicationTypeList":{"PublicationType":[{"@attributes":{"UI":"D016428"},"@text":"Journal Article"},{"@attributes":{"UI":"D013485"},"@text":"Research Support, Non-U.S. Gov't"}]}},"MedlineJournalInfo":{"Country":"England","MedlineTA":"EMBO J","NlmUniqueID":"8208664","ISSNLinking":"0261-4189"},"ChemicalList":{"Chemical":[{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D002352"},"@text":"Carrier Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D029721"},"@text":"Drosophila Proteins"}},{"RegistryNumber":"103107-01-3","NameOfSubstance":{"@attributes":{"UI":"D016222"},"@text":"Fibroblast Growth Factor 2"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D018398"},"@text":"Homeodomain Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D011506"},"@text":"Proteins"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D012333"},"@text":"RNA, Messenger"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D014157"},"@text":"Transcription Factors"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"D000099176"},"@text":"Noggin Protein"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C099257"},"@text":"ARA protein, Drosophila"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C501606"},"@text":"IRX3 protein, Xenopus"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C501599"},"@text":"Irx3 protein, mouse"}},{"RegistryNumber":"0","NameOfSubstance":{"@attributes":{"UI":"C099258"},"@text":"caup protein, Drosophila"}}]},"CitationSubset":["IM"],"MeshHeadingList":{"MeshHeading":[{"DescriptorName":{"@attributes":{"UI":"D000595","MajorTopicYN":"N"},"@text":"Amino Acid Sequence"}},{"DescriptorName":{"@attributes":{"UI":"D000818","MajorTopicYN":"N"},"@text":"Animals"}},{"DescriptorName":{"@attributes":{"UI":"D002352","MajorTopicYN":"N"},"@text":"Carrier Proteins"}},{"DescriptorName":{"@attributes":{"UI":"D004330","MajorTopicYN":"N"},"@text":"Drosophila"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D029721","MajorTopicYN":"Y"},"@text":"Drosophila Proteins"}},{"DescriptorName":{"@attributes":{"UI":"D004475","MajorTopicYN":"N"},"@text":"Ectoderm"},"QualifierName":[{"@attributes":{"UI":"Q000378","MajorTopicYN":"N"},"@text":"metabolism"}]},{"DescriptorName":{"@attributes":{"UI":"D016222","MajorTopicYN":"N"},"@text":"Fibroblast Growth Factor 2"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"N"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D018507","MajorTopicYN":"N"},"@text":"Gene Expression Regulation, Developmental"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"N"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D018398","MajorTopicYN":"N"},"@text":"Homeodomain Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D051379","MajorTopicYN":"N"},"@text":"Mice"}},{"DescriptorName":{"@attributes":{"UI":"D008969","MajorTopicYN":"N"},"@text":"Molecular Sequence Data"}},{"DescriptorName":{"@attributes":{"UI":"D009420","MajorTopicYN":"N"},"@text":"Nervous System"},"QualifierName":[{"@attributes":{"UI":"Q000196","MajorTopicYN":"Y"},"@text":"embryology"}]},{"DescriptorName":{"@attributes":{"UI":"D011506","MajorTopicYN":"N"},"@text":"Proteins"},"QualifierName":[{"@attributes":{"UI":"Q000502","MajorTopicYN":"N"},"@text":"physiology"}]},{"DescriptorName":{"@attributes":{"UI":"D012333","MajorTopicYN":"N"},"@text":"RNA, Messenger"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D017386","MajorTopicYN":"N"},"@text":"Sequence Homology, Amino Acid"}},{"DescriptorName":{"@attributes":{"UI":"D014157","MajorTopicYN":"N"},"@text":"Transcription Factors"},"QualifierName":[{"@attributes":{"UI":"Q000235","MajorTopicYN":"Y"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D014981","MajorTopicYN":"N"},"@text":"Xenopus"},"QualifierName":[{"@attributes":{"UI":"Q000196","MajorTopicYN":"N"},"@text":"embryology"},{"@attributes":{"UI":"Q000235","MajorTopicYN":"N"},"@text":"genetics"}]},{"DescriptorName":{"@attributes":{"UI":"D000099176","MajorTopicYN":"N"},"@text":"Noggin 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