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テンプレート:Estradiol metabolismのソースを表示
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テンプレート:Estradiol metabolism
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{{Annotated image 4 | image = Estradiol metabolism structures.svg | class = skin-invert | image-width = 485 | width = 485 | height = 400 | image-left = 0 | image-top = 0 | link = | align = {{{align|center}}} | caption = {{{caption|'''Description:''' The [[metabolic pathway]]s involved in the [[metabolism]] of {{No selflink|estradiol}} and other [[natural product|natural]] {{No selflink|estrogen}}s (e.g., {{No selflink|estrone}}, {{No selflink|estriol}}) in humans. In addition to the [[biotransformation|metabolic transformation]]s shown in the diagram, [[conjugation (biochemistry)|conjugation]] (e.g., [[sulfation]] and [[glucuronidation]]) occurs in the case of estradiol and [[metabolite]]s of estradiol that have one or more available [[hydroxyl group|hydroxyl]] (–OH) [[functional group|group]]s. '''Sources:''' <noinclude><ref name="The Menopause">{{cite book | veditors=Buchsbaum HJ | title=The Menopause (Clinical Perspectives in Obstetrics and Gynecology) | date=2012 | publisher=Springer Science & Business Media | location=New York, NY | isbn=9781461255253 | page=64 | url=https://books.google.com/books?id=z0LuBwAAQBAJ&pg=PA64%7Cdate=6}}</ref><ref name="Pharmacology of estrogens and progestogens">{{cite journal | vauthors = Kuhl H | title = Pharmacology of estrogens and progestogens: influence of different routes of administration | journal = Climacteric : The Journal of the International Menopause Society | volume = 8 Suppl 1 | pages = 3–63 | date = August 2005 | pmid = 16112947 | doi = 10.1080/13697130500148875 | s2cid = 24616324 }}</ref><ref name="Dorfman1961">{{cite book|title=Radioactive Isotopes in Physiology Diagnostics and Therapy|last1=Dorfman|first1=Ralph I.|chapter=Steroid Hormone Metabolism|year=1961|pages=1223–1241|doi=10.1007/978-3-642-49761-2_39|isbn=978-3-642-49477-2 }}</ref><ref name="Estrone sulfotransferase">{{cite website|title=EC 2.4.1.17 – glucuronosyltransferase and Organism(s) Homo sapiens|url=https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.1.17&Suchword=estrone&reference=&UniProtAcc=&organism%5B%5D=Homo+sapiens|website=BRENDA|publisher=Technische Universität Braunschweig|access-date=10 August 2018|date=January 2018}}</ref></noinclude><includeonly>See template page.</includeonly>}}} | alt = Graphic of the metabolic pathways of estradiol in humans | header = {{Navbar|Estradiol metabolism|mini=y}} {{{header|[[Metabolic pathway]]s of {{no selflink|estradiol}} in humans}}} | header_background = light-dark(aliceblue,var(--background-color-neutral)) | annot-font-size = 13 | annotations = <!-- Top compound row: left to right --> {{Annotation|40|68|<!-- -->{{if pagename |Estradiol='''Estradiol''' |Pharmacology of estradiol='''[[Estradiol]]''' |Estradiol (medication)='''[[Estradiol]]''' |Estrogen='''[[Estradiol]]''' |Estrogen (medication)='''[[Estradiol]]''' |other=[[Estradiol]] }} }} {{Annotation|186|68|<!-- -->{{if pagename |Estrone sulfate='''Estrone sulfate''' |Estrone sulfate (medication)='''[[Estrone sulfate]]''' |other=[[Estrone sulfate]] }} }} {{Annotation|338|83|<!-- -->{{if pagename |Estrone glucuronide='''Estrone glucuronide''' |other=[[Estrone glucuronide]] }} }} <!-- 2nd compound row: left to right --> {{Annotation|10|180|<!-- -->{{if pagename |2-Hydroxyestrone='''2-Hydroxyestrone''' |other=[[2-Hydroxyestrone]] }} }} {{Annotation|210|180|<!-- -->{{if pagename |Estrone='''Estrone''' |Estrone (medication)='''[[Estrone]]''' |Estrogen='''[[Estrone]]''' |Estrogen (medication)='''[[Estrone]]''' |other=[[Estrone]] }} }} {{Annotation|365|186|<!-- -->{{if pagename |4-Hydroxyestrone='''4-Hydroxyestrone''' |other=[[4-Hydroxyestrone]] }} }} <!-- 3rd compound row: left to right --> {{Annotation|10|280|<!-- -->{{if pagename |2-Methoxyestrone='''2-Methoxyestrone''' |other=[[2-Methoxyestrone]] }} }} {{Annotation|180|280|<!-- -->{{if pagename |16α-Hydroxyestrone='''16α-Hydroxyestrone''' |other=[[16α-Hydroxyestrone]] }} }} {{Annotation|365|295|<!-- -->{{if pagename |4-Methoxyestrone='''4-Methoxyestrone''' |other=[[4-Methoxyestrone]] }} }} <!-- Bottom compound row: left to right --> {{Annotation|25|384|<!-- -->{{if pagename |17-Epiestriol='''17-Epiestriol''' |other=[[17-Epiestriol]] }} }} {{Annotation|210|384|<!-- -->{{if pagename |Estriol='''Estriol''' |Estriol (medication)='''[[Estriol]]''' |Estrogen='''[[Estriol]]''' |Estrogen (medication)='''[[Estriol]]''' |other=[[Estriol]] }} }} {{Annotation|375|384|<!-- -->{{if pagename |16-Epiestriol='''16-Epiestriol''' |other=[[16-Epiestriol]] }} }} <!-- Enzyme labels - top --> <!-- Estradiol ←→ Estrone --> {{Annotation|150|84|[[17β-Hydroxysteroid dehydrogenase#Overview|<span style="color:DeepSkyBlue">17β-HSD</span>]]|font-size=12|text-align=left}} <!-- Estrone → Estrone sulfate --> {{Annotation|192|100|[[Estrone sulfotransferase#Types|<span style="color:DeepSkyBlue">EST</span>]]|font-size=12|text-align=right}} <!-- Estrone sulfate → Estrone --> {{Annotation|225|100|[[Steroid sulfatase|<span style="color:DeepSkyBlue">STS</span>]]|font-size=12}} <!-- Estrone → Estrone glucuronide --> {{Annotation|272|76|[[UGT1A3|<span style="color:DeepSkyBlue">UGT1A3</span>]]<br />[[UGT1A9|<span style="color:DeepSkyBlue">UGT1A9</span>]]|font-size=12}} <!-- Enzyme labels - middle-top --> <!-- Estrone → 2-Hydroxyestrone --> {{Annotation|130|134|[[CYP450|<span style="color:DeepSkyBlue">CYP450</span>]]|font-size=12}} <!-- Estrone → 4-Hydroxyestrone --> {{Annotation|296|134|[[CYP450|<span style="color:DeepSkyBlue">CYP450</span>]]|font-size=12}} <!-- Enzyme labels - middle-bottom --> <!-- 2-Hydroxyestrone → 2-Methoxyestrone --> {{Annotation|16|206|[[Catechol-O-methyltransferase|<span style="color:DeepSkyBlue">COMT</span>]]|font-size=12|text-align=right}} <!-- Estrone → 16α-Hydroxyestrone --> {{Annotation|228|198|[[CYP450|<span style="color:DeepSkyBlue">CYP450</span>]]|font-size=12|text-align=right}} <!-- 4-Hydroxyestrone → 4-Methoxyestrone --> {{Annotation|364|206|[[Catechol-O-methyltransferase|<span style="color:DeepSkyBlue">COMT</span>]]|font-size=12|text-align=right}} <!-- Enzyme labels - bottom --> <!-- 16α-Hydroxyestrone → 17-Epiestriol --> {{Annotation|128|298|unidentified|font-size=12|text-align=left}} <!-- 16α-Hydroxyestrone → Estriol --> {{Annotation|226|300|[[17β-Hydroxysteroid dehydrogenase|<span style="color:DeepSkyBlue">17β-HSD</span>]]|font-size=12}} <!-- 16α-Hydroxyestrone → 16-Epiestriol --> {{Annotation|296|298|unidentified|font-size=12|text-align=right}} }} <noinclude>{{Documentation}}</noinclude>
テンプレート:Estradiol metabolism
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