Testのソースを表示

{| class="wikitable"
|+ 表1．
|-
|	分類||対象||プローブ名||年||プローブデザイン||参考文献
|-
|rowspan="21" | 生体内小分子||	[[カルシウム]]	||Cameleon||	1997	||	3-2	||	<ref><pubmed>9278050</pubmed></ref>
|-									
|[[サイクリックGMP]] ([[cGMP]])	||CGY, Cygnet, pGES-DE2, cGi||	2000, 2001, 2006	||	3-1	||	<ref><pubmed>11140757</pubmed></ref><ref><pubmed>11226257</pubmed></ref><ref><pubmed>16369548</pubmed></ref> 
|-									
|[[サイクリックAMP]] ([[cAMP]])	||Epac||	2000,2004	||	2, 3-1	||	<ref><pubmed>11872839</pubmed></ref><ref><pubmed> 15231839</pubmed></ref> 
|-									
|[[イノシトール3リン酸]] ([[IP3|IP<sub>3</sub>]])	||LIBRA, Fretino, FIRE||	2004, 2005, 2006	||	3-1	||	<ref><pubmed>15272011</pubmed></ref><ref><pubmed> 16053285</pubmed></ref><ref><pubmed> 16754959</pubmed></ref> 
|-									
|[[一酸化窒素]] ([[NO]])	||NOA-1, Piccell||	2005, 2006	||	3-1	||	<ref><pubmed>16176986</pubmed></ref><ref><pubmed> 17165805</pubmed></ref>
|-									
|[[アデノシン3リン酸]] ([[ATP]])	||A Team 1.03-nD/nA||	2012	||	3-1	||	<ref><pubmed>19720993</pubmed></ref>
|-									
|[[エストロゲン]]	||SCCoR||	2004	||	3-3	||	<ref><pubmed>15080726</pubmed></ref>
|-									
|[[アンドロゲン]]	||Ficaro||	2006	||	3-3	||	<ref><pubmed>16555356</pubmed></ref>
|-									
|[[グルココルチコイド受容体]]リガンド	||GLUCOCOR||	2007	||	3-3	||	<ref><pubmed>17897691</pubmed></ref>
|-									
|[[神経成長因子]]	||ECaus||	2008	||	3-3	||	<ref><pubmed>18510313</pubmed></ref>
|-									
|[[核内受容体]]	||conpro||	2007	||	3-2	||	<ref><pubmed>17387660</pubmed></ref>
|-									
|[[O-N-アセチルグルコサミン]] ([[O-GlcNAc]])	|| ||	2006	||	3-3	||	<ref><pubmed>17105262</pubmed></ref>
|-									
|[[ビタミンA]] ([[レチノイン酸]])	||GEPRAS||	2013	||	3-1	||	<ref><pubmed>23563268</pubmed></ref>
|-									
|[[wj:モリブデン酸|モリブデン酸]]	||MolyProbe||	2013	||	3-1	||	<ref><pubmed>23472155</pubmed></ref>
|-									
|[[グルタミン酸]]	||FLIPE||	2005	||	3-1	||	<ref><pubmed>15939876</pubmed></ref>
|-									
|[[wj:亜鉛|Zn<sup>2+</sup>]]	||eCALWY-1||	2009	||	2	||	<ref><pubmed>19718032</pubmed></ref>
|-									
|[[wj:塩素|Cl<sup>-</sup>]]	||Clomeleon||	2000	||	other	||	<ref><pubmed>11055428</pubmed></ref>
|-									
|[[wj:水素イオン濃度|水素イオン濃度]] (pH)	||GFpH, YFpH||	2001	||	other	||	<ref><pubmed>11716495</pubmed></ref>
|-									
|[[wj:グルコース|グルコース]]	||FLIPglu||	2003	||	3-1	||	<ref><pubmed>12649277</pubmed></ref>
|-									
|[[wj:マルトース|マルトース]]||FLIPmal||	2002	||	3-1	||	<ref><pubmed>12097642</pubmed></ref>
|-									
|[[wj:リボース|リボース]]||FLIPrib||	2003	||	3-1	||	<ref><pubmed>14550551</pubmed></ref>
|-									
|rowspan="26" | 	キナーゼ	||	[[カルシウム/カルモジュリン依存製タンパク質キナーゼII]] ([[CaMKII]])	||Camui α, green-Camui α, Camk2a reporter||	2005, 2009, 2011, 2013	||	3-1	||	<ref><pubmed>15788767</pubmed></ref><ref><pubmed> 19295602</pubmed></ref><ref><pubmed> 23602566</pubmed></ref><ref><pubmed> 21506563</pubmed></ref>
|-									
|	[[Src]]	||Srcus||	2005, 2005, 2007	||	3-3	||	<ref><pubmed>11752449</pubmed></ref><ref><pubmed> 15846350</pubmed></ref><ref><pubmed> 17284441</pubmed></ref>
|-									
|	Protein kinase C (PKC)	||CKAR, CY-PKCdelta||	2003, 2005	||	3-3, 3-1	||	<ref><pubmed>12782683</pubmed></ref><ref><pubmed> 15611119</pubmed></ref>
|-									
|	Protein kinase D (PKD)	||DKAR||	2007	||	3-3	||	<ref><pubmed>17189263</pubmed></ref>
|-									
|	Protein kinase A (PKA)	||ART, AKAR||	2000, 2001	||	3-3	||	<ref><pubmed>10700148</pubmed></ref><ref><pubmed>11752448</pubmed></ref>
|-	Table 1 A list of genetically encoded FRET probes.								
|	Abl	||Picchu||	2001	||	3-3	||	<ref><pubmed>11752449</pubmed></ref>
|-	 								
|	Bcr-Abl	||Bcr-Abl activity sensor||2010	||	3-3	||	<ref><pubmed>20817824</pubmed></ref>
|-				
|	c-Raf	||Prin-cRaf||	2005	||	3-1	||	<ref><pubmed>15711535</pubmed></ref>
|-									
|	PAK1	||Pakabi||	2009	||	3-1	||	<ref><pubmed>19574218</pubmed></ref>
|-									
|	B-raf	||Prin-Braf||	2006	||	3-1	||	<ref><pubmed>16858395</pubmed></ref>
|-									
|	ZAP-70	||ROZA||	2008	||	3-3	||	<ref><pubmed>18231606</pubmed></ref>
|-									
|	Akt	||Aktus, BKAR, Akind||	2003, 2005, 2007	||	3-3	||	<ref><pubmed>12773546</pubmed></ref><ref><pubmed> 15583002</pubmed></ref><ref><pubmed> 17407381</pubmed></ref>
|-									
|	ERK	||Miu2, Erkus, EKAR||	2006, 2007, 2008	||	3-1,3-3,3-3	||	<ref><pubmed>16418172</pubmed></ref><ref><pubmed> 17261026</pubmed></ref><ref><pubmed> 19033456</pubmed></ref>
|-									
|	Insulin receptor	||Phocus||	2002	||	3-3	||	<ref><pubmed>11875431</pubmed></ref>
|-									
|	Epidermal Growth factor receptor (EGFR) 	||	||2001	||	3-3	||	<ref><pubmed>11752449</pubmed></ref>
|-									
|	Ataxia telangiectasia mutated (ATM)	||	||	2007	||	3-3	||	<ref><pubmed>17428747</pubmed></ref>
|-									
|	Aurora B kinase	||	||	2008	||	3-3	||	<ref><pubmed>18463638</pubmed></ref>
|-									
|	Cyclin B1-CDK1	||	||	2010	||	3-3	||	<ref><pubmed>20412769</pubmed></ref>
|-									
|	Myosine light chain kinase	||MLCK-FIP	||	2002	||	3-1	||	<ref><pubmed>11815633</pubmed></ref>
|-									
|	JNK	||JNKAR1, JUNKAR1EV	||	2010, 2011	||	3-3	||	<ref><pubmed>20212108</pubmed></ref><ref name=ref21976697><pubmed> 21976697</pubmed></ref>
|-									
|	RSK	||Eevee-RSK||	2011	||	3-3	||	<ref name=ref21976697></ref>
|-									
|	S6K	||Eevee-S6K||	2011	||	3-3	||	<ref name=ref21976697></ref>
|-									
|	Focal Adhesion Kinase (FAK)	||CYFAK413, FERM-sensor||	2008, 2009	||	2, 3-1	||	<ref><pubmed>17967873</pubmed></ref><ref><pubmed> 19208768</pubmed></ref>
|-									
|	PLK1	|| ||	2008	||	3-3	||	<ref><pubmed>18615013</pubmed></ref>
|-									
|	SAP3K	|| ||	2009	||	3-3	||	<ref><pubmed>19737916</pubmed></ref>
|-									
|	DAPK1	||DAPK1(334)-F40||	2011	||	3-1	||	<ref><pubmed>21506563</pubmed></ref>
|-									
|	ホスファターゼ	||	Calcineurin	||CaNAR1||	2008, 2013	||	3-1	||	<ref><pubmed>23602566</pubmed></ref><ref><pubmed> 18493642</pubmed></ref>
|-									
|rowspan="8" | Small GTPase	||	Ras	||Raichu-Ras, Fras||	2001, 2006	||	3-2,2	||	<ref><pubmed>16429133</pubmed></ref><ref name=ref11429608><pubmed> 11429608</pubmed></ref>
|-									
|	Rap	||Raichu-Rap||	2001	||	3-2	||	<ref name=ref11429608></ref>
|-									
|	Rac	||Raichu-Rac1||	2004	||	3-2	||	<ref><pubmed>14570905</pubmed></ref>
|-									
|	Rab5	||Raichu-Rab5||	2008	||	3-2	||	<ref><pubmed>18385674</pubmed></ref>
|-									
|	Rho	||Raichu-RhoA||	2003, 2011	||	3-2, 2	||	<ref><pubmed>21423166</pubmed></ref><ref><pubmed> 12860967</pubmed></ref>
|-									
|	Cdc42	||Raichu-cdc42||	2004, 2011	||	3-2, 2	||	<ref><pubmed>14570905</pubmed></ref><ref><pubmed> 21423166</pubmed></ref>
|-									
|	Ral	||Raichu-Ral||	2004	||	3-3	||	<ref><pubmed>15034142</pubmed></ref>
|-									
|	TC10	||Raichu-TC10||	2006	||	3-2	||	<ref><pubmed>16950130</pubmed></ref>
|-									
|rowspan="6" | Signal transduction	||	RCC1(GEF of Ran)	||CFP-RCC1-YFP||	2008	||	3-1	||	<ref><pubmed>18762580</pubmed></ref>
|-									
|	CrkII phosphorylation	||Picchu||	2001	||	3-1	||	<ref><pubmed>11406630</pubmed></ref>
|-									
|	N-WASP	||Stinger||	2004	||	3-1	||	<ref><pubmed>15084285</pubmed></ref><ref><pubmed> 14732696</pubmed></ref>
|-									
|	Adrenergic receptor	||α<sub>2A</sub>AR-cam||	2003	||	3-1	||	<ref name=ref12808462><pubmed>12808462</pubmed></ref>
|-									
|	Parathyroid hormone receptor	||PTHR-cam||	2003	||	3-1	||	<ref name=ref12808462></ref>
|-									
|	Plasma membrane Calcium pump	||BFP-PMCA-GFP||	2007	||	3-1	||	<ref><pubmed>17901055</pubmed></ref>
|-									
|	Acetylation	||	Histone acetylation	||Histac||	2004, 2009	||	3-3	||	<ref><pubmed>15137760</pubmed></ref><ref><pubmed> 19805290</pubmed></ref>
|-									
|rowspan="6" | Lipid	||	Phosphatidylinositol (3,4,5)-trisphosphate (PIP3)	||Fllip, FLIMPA||	2003	||	3-4	||	<ref><pubmed>14528311</pubmed></ref>
|-									
|	Phosphatidylinositol (4,5)-bisphosphate (PIP2)	||Pippi-PI(4,5)P<sub>2</sub>||	2008	||	3-4	||	<ref name=ref18685081><pubmed>18685081</pubmed></ref>
|-									
|	Phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P2) 	||Pippi-PI(3,4)P<sub>2</sub>||	2008	||	3-4	||	<ref name=ref18685081></ref>
|-									
|	Phosphatidylinositol 4-phosphate (PI4P)	||Pippi-PI(4)P||	2008	||	3-4	||	<ref name=ref18685081></ref>
|-									
|	Phosphatidic acid	||Pii||	2010	||	3-4	||	<ref><pubmed>20826779</pubmed></ref>
|-									
|	Diacylglycerol (DAG)	||Daglas, DIGDA||	2006, 2008	||	3-4	||	<ref><pubmed>18685081</pubmed></ref><ref><pubmed> 16990811</pubmed></ref>
|-									
|rowspan="6" | Protein interaction	||	Actin	||	||2004, 2008	||	2	||	<ref><pubmed>15361876</pubmed></ref><ref><pubmed> 18512154</pubmed></ref>
|-									
|	PDK1-Akt interaction	||	||2007	||	2	||	<ref><pubmed>17407381</pubmed></ref>
|-									
|	Protein tyrosine phosphatase 1B-receptor tyrosine kinases (PTP 1B-RTKs) interaction	|| ||	2002	||	2	||	<ref><pubmed>11872838</pubmed></ref>
|-									
|	Breast cancer resistance protein/ATP-binding cassette sub-family G member) BCRP/ABCG	||	||2010	||	2	||	<ref><pubmed>20622991</pubmed></ref>
|-									
|	Cofiin-actin interaction	||	||2008	||	2	||	<ref><pubmed>17993279</pubmed></ref>
|-									
|	PTEN-Myosin V interaction	||	||2009	||	2	||	<ref><pubmed>19767745</pubmed></ref>
|-									
|rowspan="8" | Protease	||	Caspase-3	||EGFP-DEVD-EBFP||	1998	||	1	||	<ref><pubmed>9518501</pubmed></ref>
|-									
|	Caspase-8	||CFP-c3-YFP-c6-mRFP||	2002	||	1	||	<ref><pubmed>12409609</pubmed></ref>
|-									
|	Caspase-9	||SCAT9||	2011	||	1	||	<ref><pubmed>21637712</pubmed></ref>
|-									
|	Caspase-7	||VDEVDc||	2006	||	1	||	<ref><pubmed>17946841</pubmed></ref>
|-									
|	Matrix Metalloproteinase (MMP)	||YFP-MSS-CFP<sup>display</sup>, MTI-MMP-FRET biosensor||	2007, 2008	||	1	||	<ref><pubmed>17187878</pubmed></ref><ref><pubmed> 18441011</pubmed></ref> 
|-									
|	Protease activity (Factor Xa)	||	||1996	||	1	||	<ref><pubmed>8707050</pubmed></ref>
|-									
|	Calpain activity	||pYSCS||	2000	||	1	||	<ref><pubmed>10688895</pubmed></ref>
|-									
|	Presenilin	||GFP-PSI-RFP||	2009	||	3-1	||	<ref><pubmed>19924286</pubmed></ref>
|-									
|rowspan="5" | Other	||	Strain sensor	||stFRET||	2008	||	3-1	||	<ref><pubmed>18479457</pubmed></ref>
|-									
|	Membrane potential	||VSFP, Mermaid, ArcLight, VSFP-Butterfly||	2001, 2008, 2012	||	3-1	||	<ref><pubmed>11454036</pubmed></ref><ref><pubmed> 18622396</pubmed></ref><ref><pubmed> 22958819</pubmed></ref>
|-									
|	Myosin II	||GSldCB||	1998, 2006	||	3-1	||	<ref><pubmed>9845076</pubmed></ref><ref><pubmed> 16939200</pubmed></ref>
|-									
|	HIV Rev protein	||YRGnC-11ad||	2005	||	3-1	||	<ref><pubmed>16013840</pubmed></ref>
|-									
||	Redox	||Redoxfluor, Gaskins||	2010, 2011	||	3-1	||	<ref><pubmed>20498274</pubmed></ref><ref><pubmed> 21606117</pubmed></ref>
|}

The numbers in the Probe Design column correspond to the section number in the “Strategies of probe design” chapter of the main text. See the webpage by Dr. Michiyuki Matsuda http://www.lif.kyoto-u.ac.jp/labs/fret/e-phogemon/unifret.htm for updated information. 				

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