Testのソースを表示

{| class="wikitable"
|+ 表1．
|-
|	分類||対象||プローブ名||年||プローブデザイン||参考文献
|-
|rowspan="21" | 生体内小分子||	[[カルシウム]]	||Cameleon||	1997	||	3-2	||	<ref><pubmed>9278050</pubmed></ref>
|-									
|[[サイクリックGMP]] ([[cGMP]])	||CGY, Cygnet, pGES-DE2, cGi||	2000, 2001, 2006	||	3-1	||	<ref><pubmed>11140757</pubmed></ref><ref><pubmed>11226257</pubmed></ref><ref><pubmed>16369548</pubmed></ref><ref><pubmed>23801067</pubmed></ref>  
|-									
|[[サイクリックAMP]] ([[cAMP]])	||Epac||	2000,2004	||	2, 3-1	||	<ref><pubmed>11872839</pubmed></ref><ref><pubmed> 15231839</pubmed></ref> 
|-									
|[[イノシトール3リン酸]] ([[IP3|IP<sub>3</sub>]])	||LIBRA, Fretino, FIRE||	2004, 2005, 2006	||	3-1	||	<ref><pubmed>15272011</pubmed></ref><ref><pubmed> 16053285</pubmed></ref><ref><pubmed> 16754959</pubmed></ref> 
|-									
|[[一酸化窒素]] ([[NO]])	||NOA-1, Piccell||	2005, 2006	||	3-1	||	<ref><pubmed>16176986</pubmed></ref><ref><pubmed> 17165805</pubmed></ref>
|-									
|[[アデノシン3リン酸]] ([[ATP]])	||A Team 1.03-nD/nA||	2012	||	3-1	||	<ref><pubmed>19720993</pubmed></ref>
|-									
|[[エストロゲン]]	||SCCoR||	2004	||	3-3	||	<ref><pubmed>15080726</pubmed></ref>
|-									
|[[アンドロゲン]]	||Ficaro||	2006	||	3-3	||	<ref><pubmed>16555356</pubmed></ref>
|-									
|[[グルココルチコイド受容体]]リガンド	||GLUCOCOR||	2007	||	3-3	||	<ref><pubmed>15163683</pubmed></ref><ref><pubmed>17897691</pubmed></ref>
|-									
|[[神経成長因子]]	||ECaus||	2008	||	3-3	||	<ref><pubmed>18510313</pubmed></ref>
|-									
|[[核内受容体]]	||conpro||	2007	||	3-2	||	<ref><pubmed>17387660</pubmed></ref>
|-									
|[[O-N-アセチルグルコサミン]] ([[O-GlcNAc]])	|| ||	2006	||	3-3	||	<ref><pubmed>17105262</pubmed></ref>
|-									
|[[ビタミンA]] ([[レチノイン酸]])	||GEPRAS||	2013	||	3-1	||	<ref><pubmed>23563268</pubmed></ref>
|-									
|[[wj:モリブデン酸|モリブデン酸]]	||MolyProbe||	2013	||	3-1	||	<ref><pubmed>23472155</pubmed></ref>
|-									
|[[グルタミン酸]]	||FLIPE||	2005	||	3-1	||	<ref><pubmed>15939876</pubmed></ref>
|-									
|[[wj:亜鉛|Zn<sup>2+</sup>]]	||eCALWY-1||	2009	||	2	||	<ref><pubmed>19718032</pubmed></ref>
|-									
|[[wj:塩素|Cl<sup>-</sup>]]	||Clomeleon||	2000	||	other	||	<ref><pubmed>11055428</pubmed></ref>
|-									
|[[wj:水素イオン濃度|水素イオン濃度]] (pH)	||GFpH, YFpH||	2001	||	other	||	<ref><pubmed>11716495</pubmed></ref>
|-									
|[[wj:グルコース|グルコース]]	||FLIPglu||	2003	||	3-1	||	<ref><pubmed>12649277</pubmed></ref>
|-									
|[[wj:マルトース|マルトース]]||FLIPmal||	2002	||	3-1	||	<ref><pubmed>12097642</pubmed></ref>
|-									
|[[wj:リボース|リボース]]||FLIPrib||	2003	||	3-1	||	<ref><pubmed>14550551</pubmed></ref>
|-									
|rowspan="25" | 	タンパク質リン酸化酵素	||	[[カルシウム/カルモジュリン依存性タンパク質リン酸化酵素II]] ([[CaMKII]])	||Camui α, green-Camui α, Camk2a reporter||	2005, 2009, 2011, 2013	||	3-1	||	<ref><pubmed>15788767</pubmed></ref><ref><pubmed> 19295602</pubmed></ref><ref name=ref23602566><pubmed> 23602566</pubmed></ref><ref name=ref21506563><pubmed> 21506563</pubmed></ref>
|-									
|	[[Src]]	||Srcus||	2005, 2005, 2007	||	3-3	||	<ref name=ref11752449><pubmed>11752449</pubmed></ref><ref><pubmed> 15846350</pubmed></ref><ref><pubmed> 17284441</pubmed></ref>
|-									
|	[[Ca2+／リン脂質依存性タンパク質リン酸化酵素|Ca<sup>2+</sup>／リン脂質依存性タンパク質リン酸化酵素]] ([[Cキナーゼ]], [[プロテインキナーゼC]], [[PKC]])	||CKAR, CY-PKCdelta||	2003, 2005	||	3-3, 3-1	||	<ref><pubmed>12782683</pubmed></ref><ref><pubmed> 15611119</pubmed></ref>
|-									
|	[[タンパク質リン酸化酵素D]] ([[Dキナーゼ]], [[プロテインキナーゼD]], [[PKD]])	||DKAR||	2007	||	3-3	||	<ref><pubmed>17189263</pubmed></ref>
|-									
|	[[cAMP依存性タンパク質リン酸化酵素]] ([[Aキナーゼ]], [[プロテインキナーゼA]], [[PKA]])	||ART, AKAR||	2000, 2001	||	3-3	||	<ref><pubmed>10700148</pubmed></ref><ref><pubmed>11752448</pubmed></ref>
|-								
|	[[Abl]]	||Picchu||	2001	||	3-3	||	<ref name=ref11752449 />
|-	 								
|	[[Bcr]]-Abl	||Bcr-Abl activity sensor||2010	||	3-3	||	<ref><pubmed>20817824</pubmed></ref>
|-				
|	[[c-Raf]]	||Prin-cRaf||	2005	||	3-1	||	<ref><pubmed>15711535</pubmed></ref>
|-									
|	[[P21 protein-activated kinase 1]] ([[PAK1]])	||Pakabi||	2009	||	3-1	||	<ref><pubmed>19574218</pubmed></ref>
|-									
|	[[B-raf]]	||Prin-Braf||	2006	||	3-1	||	<ref><pubmed>16858395</pubmed></ref>
|-									
|	[[Zeta-chain-associated protein kinase 70]] ([[ZAP-70]])	||ROZA||	2008	||	3-3	||	<ref><pubmed>18231606</pubmed></ref>
|-									
|	[[Akt]]	||Aktus, BKAR, Akind||	2003, 2005, 2007	||	3-3	||	<ref><pubmed>12773546</pubmed></ref><ref><pubmed> 15583002</pubmed></ref><ref name=ref17407381><pubmed> 17407381</pubmed></ref>
|-									
|	[[細胞外シグナル調節キナーゼ]] ([[Extracellular signal-regulated kinases]], [[ERK]])	||Miu2, Erkus, EKAR||	2006, 2007, 2008	||	3-1,3-3,3-3	||	<ref><pubmed>16418172</pubmed></ref><ref><pubmed> 17261026</pubmed></ref><ref><pubmed> 19033456</pubmed></ref>
|-									
|	[[インシュリン受容体]]	||Phocus||	2002	||	3-3	||	<ref><pubmed>11875431</pubmed></ref>
|-									
|	[[上皮成長因子受容体]] ([[EGFR]]) 	||	||2001	||	3-3	||	<ref name=ref11752449 />
|-									
|	[[Ataxia telangiectasia mutated]] ([[ATM]])	||	||	2007	||	3-3	||	<ref><pubmed>17428747</pubmed></ref>
|-									
|[[オーロラBキナーゼ]]	||	||	2008	||	3-3	||	<ref><pubmed>18463638</pubmed></ref>
|-									
|	[[サイクリンB1]]-[[サイクリン依存性キナーゼ1]]	||	||	2010	||	3-3	||	<ref><pubmed>20412769</pubmed></ref>
|-									
|	[[ミオシン軽鎖キナーゼ]]	||MLCK-FIP	||	2002	||	3-1	||	<ref><pubmed>11815633</pubmed></ref>
|-									
|	[[c-Jun N端末キナーゼ]] ([[JNK]])	||JNKAR1, JUNKAR1EV	||	2010, 2011	||	3-3	||	<ref><pubmed>20212108</pubmed></ref><ref name=ref21976697><pubmed> 21976697</pubmed></ref>
|-									
|	[[リボソームS6キナーゼ]] ([[RSK]], [[S6K]])	||Eevee-RSK, Eevee-S6K||	2011	||	3-3	||	<ref name=ref21976697></ref>
|-									
|	[[接着斑キナーゼ]] ([[Focal Adhesion Kinase]], [[FAK]])	||CYFAK413, FERM-sensor||	2008, 2009	||	2, 3-1	||	<ref><pubmed>17967873</pubmed></ref><ref><pubmed> 19208768</pubmed></ref>
|-									
|	[[Polo様キナーゼ1]] ([[polo-like kinase1]], [[PLK1]])	|| ||	2008	||	3-3	||	<ref><pubmed>18615013</pubmed></ref>
|-									
|	[[ストレス活性化プロテインキナーゼ3]] ([[Stress-Activated Protein Kinase Kinase Kinase]], [[stress-activated protein kinase 3]], [[SAP3K]])	|| ||	2009	||	3-3	||	<ref><pubmed>19737916</pubmed></ref>
|-									
|	[[細胞死関連タンパク質キナーゼ]] ([[death associated protein kinase 1]], [[DAPK1]])	||DAPK1(334)-F40||	2011	||	3-1	||	<ref name=ref21506563 />
|-									
|	[[ホスファターゼ]]	||	[[カルシニューリン]]	||CaNAR1||	2008, 2013	||	3-1	||	<ref name=ref23602566 /><ref><pubmed> 18493642</pubmed></ref>
|-									
|rowspan="8" | [[低分子量Gタンパク質]]	||	[[Ras]]	||Raichu-Ras, Fras||	2001, 2006	||	3-2,2	||	<ref><pubmed>16429133</pubmed></ref><ref name=ref11429608><pubmed> 11429608</pubmed></ref>
|-									
|	[[Rap]]	||Raichu-Rap||	2001	||	3-2	||	<ref name=ref11429608></ref>
|-									
|	[[Rac]]	||Raichu-Rac1||	2004	||	3-2	||	<ref name=ref14570905><pubmed>14570905</pubmed></ref>
|-									
|	[[Rab5]]	||Raichu-Rab5||	2008	||	3-2	||	<ref><pubmed>18385674</pubmed></ref>
|-									
|	[[Rho]]	||Raichu-RhoA||	2003, 2011	||	3-2, 2	||	<ref name=ref21423166><pubmed>21423166</pubmed></ref><ref><pubmed> 12860967</pubmed></ref>
|-									
|	[[Cdc42]]	||Raichu-cdc42||	2004, 2011	||	3-2, 2	||	<ref name=ref14570905 /><ref name=ref21423166 />
|-									
|	[[Ral]]	||Raichu-Ral||	2004	||	3-3	||	<ref><pubmed>15034142</pubmed></ref>
|-									
|	[[TC10]]	||Raichu-TC10||	2006	||	3-2	||	<ref><pubmed>16950130</pubmed></ref>
|-									
|rowspan="6" | [[シグナル伝達]]	||	RCC1(GEF of Ran)	||CFP-RCC1-YFP||	2008	||	3-1	||	<ref><pubmed>18762580</pubmed></ref>
|-									
|	CrkII phosphorylation	||Picchu||	2001	||	3-1	||	<ref><pubmed>11406630</pubmed></ref>
|-									
|	N-WASP	||Stinger||	2004	||	3-1	||	<ref><pubmed>15084285</pubmed></ref><ref><pubmed> 14732696</pubmed></ref>
|-									
|	アドレナリン受容体	||α<sub>2A</sub>AR-cam||	2003	||	3-1	||	<ref name=ref12808462><pubmed>12808462</pubmed></ref>
|-									
|	Parathyroid hormone receptor	||PTHR-cam||	2003	||	3-1	||	<ref name=ref12808462 />
|-									
|	細胞膜カルシウムポンプ 	||BFP-PMCA-GFP||	2007	||	3-1	||	<ref><pubmed>17901055</pubmed></ref>
|-									
|	アセチル化	||	ヒストンアセチル化	||Histac||	2004, 2009	||	3-3	||	<ref><pubmed>15137760</pubmed></ref><ref><pubmed> 19805290</pubmed></ref>
|-									
|rowspan="6" | 脂質	||	Phosphatidylinositol (3,4,5)-trisphosphate (PIP3)	||Fllip, FLIMPA||	2003	||	3-4	||	<ref><pubmed>14528311</pubmed></ref>
|-									
|	Phosphatidylinositol (4,5)-bisphosphate (PIP2)	||Pippi-PI(4,5)P<sub>2</sub>||	2008	||	3-4	||	<ref name=ref18685081><pubmed>18685081</pubmed></ref>
|-									
|	Phosphatidylinositol (3,4)-bisphosphate (PI(3,4)P2) 	||Pippi-PI(3,4)P<sub>2</sub>||	2008	||	3-4	||	<ref name=ref18685081 />
|-									
|	Phosphatidylinositol 4-phosphate (PI4P)	||Pippi-PI(4)P||	2008	||	3-4	||	<ref name=ref18685081 />
|-									
|	ホスファチジン酸	||Pii||	2010	||	3-4	||	<ref><pubmed>20826779</pubmed></ref>
|-									
|	ジアシルグリセロール (DAG)	||Daglas, DIGDA||	2006, 2008	||	3-4	||	<ref name=ref18685081 /><ref><pubmed> 16990811</pubmed></ref>
|-									
|rowspan="6" | タンパク質相互作用	||	アクチン	||	||2004, 2008	||	2	||	<ref><pubmed>15361876</pubmed></ref><ref><pubmed> 18512154</pubmed></ref>
|-									
|	PDK1-Akt interaction	||	||2007	||	2	||	<ref name=ref17407381 />
|-									
|	Protein tyrosine phosphatase 1B-receptor tyrosine kinases (PTP 1B-RTKs) interaction	|| ||	2002	||	2	||	<ref><pubmed>11872838</pubmed></ref>
|-									
|	Breast cancer resistance protein/ATP-binding cassette sub-family G member) BCRP/ABCG	||	||2010	||	2	||	<ref><pubmed>20622991</pubmed></ref>
|-									
|	Cofiin-actin interaction	||	||2008	||	2	||	<ref><pubmed>17993279</pubmed></ref>
|-									
|	PTEN-Myosin V interaction	||	||2009	||	2	||	<ref><pubmed>19767745</pubmed></ref>
|-									
|rowspan="8" | プロテアーゼ	||	カスパーゼ-3	||EGFP-DEVD-EBFP||	1998	||	1	||	<ref><pubmed>9518501</pubmed></ref>
|-									
|	カスパーゼ-8	||CFP-c3-YFP-c6-mRFP||	2002	||	1	||	<ref><pubmed>12409609</pubmed></ref>
|-									
|	カスパーゼ-9	||SCAT9||	2011	||	1	||	<ref><pubmed>21637712</pubmed></ref>
|-									
|	カスパーゼ-7	||VDEVDc||	2006	||	1	||	<ref><pubmed>17946841</pubmed></ref>
|-									
|	マトリックスメタロプロテアーゼ (MMP)	||YFP-MSS-CFP<sup>display</sup>, MTI-MMP-FRET biosensor||	2007, 2008	||	1	||	<ref><pubmed>17187878</pubmed></ref><ref><pubmed> 18441011</pubmed></ref> 
|-									
|	プロテアーゼ活性 (Factor Xa)	||	||1996	||	1	||	<ref><pubmed>8707050</pubmed></ref>
|-									
|カルパイン活性||pYSCS||	2000	||	1	||	<ref><pubmed>10688895</pubmed></ref>
|-									
|	プレセニリン	||GFP-PSI-RFP||	2009	||	3-1	||	<ref><pubmed>19924286</pubmed></ref>
|-									
|rowspan="5" | その他	||	Strain sensor	||stFRET||	2008	||	3-1	||	<ref><pubmed>18479457</pubmed></ref>
|-									
|	膜電位	||VSFP, Mermaid, ArcLight, VSFP-Butterfly||	2001, 2008, 2012	||	3-1	||	<ref><pubmed>11454036</pubmed></ref><ref><pubmed> 18622396</pubmed></ref><ref><pubmed> 22958819</pubmed></ref><ref><pubmed> 23868559</pubmed></ref>
|-									
|	ミオシン II	||GSldCB||	1998, 2006	||	3-1	||	<ref><pubmed>9845076</pubmed></ref><ref><pubmed> 16939200</pubmed></ref>
|-									
|	ヒト免疫不全ウイルスRevタンパク質	||YRGnC-11ad||	2005	||	3-1	||	<ref><pubmed>16013840</pubmed></ref>
|-									
||	レドックス	||Redoxfluor, Gaskins||	2010, 2011	||	3-1	||	<ref><pubmed>20498274</pubmed></ref><ref><pubmed> 21606117</pubmed></ref>
|}

The numbers in the Probe Design column correspond to the section number in the “Strategies of probe design” chapter of the main text. See the webpage by Dr. Michiyuki Matsuda http://www.lif.kyoto-u.ac.jp/labs/fret/e-phogemon/unifret.htm for updated information. 				

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