テンプレート:PBB/1950のソースを表示

{{GNF_Protein_box
 | Name = Epidermal growth factor
 | image = 1a3p_egf.png
 | image_source = Rainbow colored [[protein nuclear magnetic resonance spectroscopy|NMR structure]] ([[N-terminus]] = blue, [[C-terminus]] = red) of the mouse epidermal growth factor<ref name="pmid10082370"><pubmed>10082370</pubmed></ref>.
 | PDB = {{PDB2|1IVO}}, {{PDB2|1JL9}}, {{PDB2|1NQL}}, {{PDB2|1P9J}}, {{PDB2|3NJP}}
 | HGNCid = 3229
 | MGIid = 95290
 | Symbol = EGF
 | AltSymbols =; HOMG4; URG
 | IUPHAR = 
 | ChEMBL = 5734
 | OMIM = 131530
 | ECnumber = 
 | Homologene = 1483
 | GeneAtlas_image1 = PBB_GE_EGF_206254_at_tn.png
 | GeneAtlas_image2 = 
 | GeneAtlas_image3 = 
 | Protein_domain_image = 
 | Function = {{GNF_GO|id=GO:0005154 |text = epidermal growth factor receptor binding}} {{GNF_GO|id=GO:0005509 |text = calcium ion binding}} {{GNF_GO|id=GO:0005515 |text = protein binding}} {{GNF_GO|id=GO:0008083 |text = growth factor activity}} {{GNF_GO|id=GO:0030297 |text = transmembrane receptor protein tyrosine kinase activator activity}}
 | Component = {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005576 |text = extracellular region}} {{GNF_GO|id=GO:0005615 |text = extracellular space}} {{GNF_GO|id=GO:0005625 |text = soluble fraction}} {{GNF_GO|id=GO:0005886 |text = plasma membrane}} {{GNF_GO|id=GO:0016021 |text = integral to membrane}} {{GNF_GO|id=GO:0031093 |text = platelet alpha granule lumen}}
 | Process = {{GNF_GO|id=GO:0000186 |text = activation of MAPKK activity}} {{GNF_GO|id=GO:0001525 |text = angiogenesis}} {{GNF_GO|id=GO:0002576 |text = platelet degranulation}} {{GNF_GO|id=GO:0006260 |text = DNA replication}} {{GNF_GO|id=GO:0007165 |text = signal transduction}} {{GNF_GO|id=GO:0007171 |text = activation of transmembrane receptor protein tyrosine kinase activity}} {{GNF_GO|id=GO:0007173 |text = epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0007262 |text = STAT protein import into nucleus}} {{GNF_GO|id=GO:0007596 |text = blood coagulation}} {{GNF_GO|id=GO:0008284 |text = positive regulation of cell proliferation}} {{GNF_GO|id=GO:0010800 |text = positive regulation of peptidyl-threonine phosphorylation}} {{GNF_GO|id=GO:0021940 |text = positive regulation of cerebellar granule cell precursor proliferation}} {{GNF_GO|id=GO:0030168 |text = platelet activation}} {{GNF_GO|id=GO:0035413 |text = positive regulation of catenin import into nucleus}} {{GNF_GO|id=GO:0042059 |text = negative regulation of epidermal growth factor receptor signaling pathway}} {{GNF_GO|id=GO:0042327 |text = positive regulation of phosphorylation}} {{GNF_GO|id=GO:0043388 |text = positive regulation of DNA binding}} {{GNF_GO|id=GO:0043406 |text = positive regulation of MAP kinase activity}} {{GNF_GO|id=GO:0045741 |text = positive regulation of epidermal growth factor-activated receptor activity}} {{GNF_GO|id=GO:0045741 |text = positive regulation of epidermal growth factor-activated receptor activity}} {{GNF_GO|id=GO:0045840 |text = positive regulation of mitosis}} {{GNF_GO|id=GO:0045893 |text = positive regulation of transcription, DNA-dependent}} {{GNF_GO|id=GO:0048754 |text = branching morphogenesis of a tube}} {{GNF_GO|id=GO:0050708 |text = regulation of protein secretion}} {{GNF_GO|id=GO:0050730 |text = regulation of peptidyl-tyrosine phosphorylation}} {{GNF_GO|id=GO:0051048 |text = negative regulation of secretion}} {{GNF_GO|id=GO:0060749 |text = mammary gland alveolus development}} {{GNF_GO|id=GO:0070371 |text = ERK1 and ERK2 cascade}} {{GNF_GO|id=GO:0090279 |text = regulation of calcium ion import}} {{GNF_GO|id=GO:0090370 |text = negative regulation of cholesterol efflux}} {{GNF_GO|id=GO:2000008 |text = regulation of protein localization at cell surface}} {{GNF_GO|id=GO:2000060 |text = positive regulation of protein ubiquitination involved in ubiquitin-dependent protein catabolic process}}
 | Hs_EntrezGene = 1950
 | Hs_Ensembl = ENSG00000138798
 | Hs_RefseqmRNA = NM_001178130.1
 | Hs_RefseqProtein = NP_001171601.1
 | Hs_GenLoc_db = hg19
 | Hs_GenLoc_chr = 4
 | Hs_GenLoc_start = 110834040
 | Hs_GenLoc_end = 110933422
 | Hs_Uniprot = P01133
 | Mm_EntrezGene = 13645
 | Mm_Ensembl = ENSMUSG00000028017
 | Mm_RefseqmRNA = NM_010113.3
 | Mm_RefseqProtein = NP_034243.2
 | Mm_GenLoc_db = mm9
 | Mm_GenLoc_chr = 3
 | Mm_GenLoc_start = 129380493
 | Mm_GenLoc_end = 129458240
 | Mm_Uniprot = P01132
 | path = PBB/1950
}}