気分安定薬のソースを表示

<div align="right">  
<font size="+1">[http://researchmap.jp/tadafumikato 加藤 忠史]</font><br>
''独立行政法人理化学研究所　脳科学総合研究センター''<br>
DOI：<selfdoi />　原稿受付日：2013年3月16日　原稿完成日：2013年5月28日<br>
担当編集委員：[http://researchmap.jp/ryosuketakahashi 高橋 良輔]（京都大学大学院医学研究科）<br>
</div>

{{Drugbox
| drug_name         = Lithium
| IUPAC_name        = Lithium(1+)
| image             = Stylised Lithium Atom.svg
| width             = 220px
| alt               = 
| caption           = 

<!-- Clinical data -->
| tradename         = Eskalith, Lithobid and others
| Drugs.com         = {{Drugs.com|parent|lithium}}
| MedlinePlus       = a681039
| pregnancy_AU      = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US      = D
| pregnancy_category= 
| legal_AU = S4
| legal_CA = <!-- OTC, Rx-only, Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, CD Lic, CD POM, CD No Reg POM, CD (Benz) POM, CD (Anab) POM or CD Inv POM -->
| legal_US = Rx-only
| legal_status      = 
| routes_of_administration = Oral, [[parenteral]]

<!-- Pharmacokinetic data -->
| bioavailability   = depends on formulation
| protein_bound     = 
| metabolism        = 
| elimination_half-life = 24 hrs
| excretion         = >95% [[renal]]

<!-- Identifiers -->
| CAS_number        = 7439-93-2
| ATCvet            = 
| ATC_prefix        = N05
| ATC_suffix        = AN01
| [[PubChem]]           = 28486
| [[DrugBank]]          = DB01356

<!-- Chemical data -->
| chemical_formula  = Li<sup>+</sup>
| molecular_weight  = 6.941 g/mol
| smiles = [Li+]
| StdInChI = 1S/Li/q+1
| StdInChIKey = HBBGRARXTFLTSG-UHFFFAOYSA-N
}}
{{drugbox
|drug_name         =Lamotrigine
| Verifiedfields = changed
| verifiedrevid = 420280917
| IUPAC_name = 6-(2,3-dichlorophenyl)-1,2,4-triazine-3,5-diamine
| image = Lamotrigine.svg
| width = 220
| image2 = Lamotrigine_3d_structure.png

<!--Clinical data-->
| tradename = Lamictal
| Drugs.com = {{drugs.com|monograph|lamotrigine}}
| MedlinePlus = a695007
| pregnancy_US = C
| legal_UK = POM
| legal_US = Rx-only
| routes_of_administration = Oral

<!--Pharmacokinetic data-->
| bioavailability = 98%
| protein_bound = 55%
| metabolism = [[Liver|Hepatic]] (mostly [[UGT1A4]]-mediated)
| elimination_half-life = 24–34 hours (healthy adults)
| excretion = [[Kidney|Renal]]

<!--Identifiers-->
| CASNo_Ref = {{cascite|correct|CAS}}
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 84057-84-1
| ATC_prefix = N03
| ATC_suffix = AX09
| [[PubChem]] = 3878
| IUPHAR_ligand = 2622
| DrugBank_Ref = {{drugbankcite|changed|[[DrugBank|drugbank]]}}
| DrugBank = DB00555
| ChemSpiderID_Ref = {{chemspidercite|correct|[[ChemSpider|chemspider]]}}
| ChemSpiderID = 3741
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = U3H27498KS
| KEGG_Ref = {{keggcite|correct|[[KEGG|kegg]]}}
| [[KEGG]] = D00354
| ChEBI_Ref = {{ebicite|changed|EBI}}
| [[ChEBI]] = 6367
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| [[ChEMBL]] = 741

<!--Chemical data-->
| C=9 | H=7 | Cl=2 | N=5
| molecular_weight = 256.091 g/mol
| smiles = Clc2c(Cl)c(c1nnc(nc1N)N)ccc2
| InChI = 1/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C9H7Cl2N5/c10-5-3-1-2-4(6(5)11)7-8(12)14-9(13)16-15-7/h1-3H,(H4,12,13,14,16)
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = PYZRQGJRPPTADH-UHFFFAOYSA-N
}}
{{Drugbox
|drug_name=Sodium valproate
| verifiedrevid = 464404696
| IUPAC_name = sodium 2-propylpentanoate
| image = Sodium-valproate-2D-skeletal.png
| width = 220

<!--Clinical data-->
| tradename =  
| Drugs.com = {{drugs.com|monograph|valproate-sodium}}
| MedlinePlus = a682412
| pregnancy_AU = D
| pregnancy_US = D
| legal_status = rx-only
| routes_of_administration = Oral, [[Intravenous|i.v.]]

<!--Pharmacokinetic data-->
| bioavailability =  
| protein_bound = 90–95%
| metabolism = 75% by [[Cytochrome P450|CYP]] enzymes
| elimination_half-life = 9–18 hours
| excretion = 20% excreted as [[glucuronidation|glucuronide]]

<!--Identifiers-->
| CASNo_Ref = {{cascite|correct|CAS}}
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 1069-66-5
| ATC_prefix = N03
| ATC_suffix = AG01
| PubChem = 14047
| DrugBank_Ref = {{drugbankcite|correct|drugbank}}
| DrugBank =  
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 13428
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 5VOM6GYJ0D
| KEGG_Ref = {{keggcite|correct|kegg}}
| KEGG = D00710
| ChEBI_Ref = {{ebicite|correct|EBI}}
| [[ChEBI]] = 9925
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| [[ChEMBL]] = 433

<!--Chemical data-->
 | C=8 | H=15 | Na=1 | O=2 
| molecular_weight = 166.20 g/mol
| smiles = [Na+].[O-]C(=O)C(CCC)CCC
| InChI = 1/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
| InChIKey = AEQFSUDEHCCHBT-REWHXWOFAT
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C8H16O2.Na/c1-3-5-7(6-4-2)8(9)10;/h7H,3-6H2,1-2H3,(H,9,10);/q;+1/p-1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = AEQFSUDEHCCHBT-UHFFFAOYSA-M
}}
{{Drugbox
|drug_name=Carbamazepine
|verifiedrevid=451682337
|IUPAC_name=5''H''-dibenzo[''b'',''f'']azepine-5-carboxamide
|image=Carbamazepine Structural Formulae.png
|width=220
|image2=Carbamazepine 3D.png
|width2=220

<!--Clinical data-->
|tradename=Tegretol
|Drugs.com={{drugs.com|monograph|carbamazepine}}
|MedlinePlus=a682237
|pregnancy_US=D
|legal_UK=POM
|legal_US=Rx-only
|routes_of_administration=Oral

<!--Pharmacokinetic data-->
|bioavailability=80%
|protein_bound=76%
|metabolism=[[Liver|Hepatic]]—by [[CYP3A4]], to active [[epoxide]] form (carbamazepine-10,11 epoxide)
|elimination_half-life=25–65 hours (after several doses 12–17 hours)
|excretion=2–3% excreted unchanged in urine

<!--Identifiers-->
|CASNo_Ref={{cascite|correct|CAS}}
|CAS_number_Ref={{cascite|correct|??}}
|CAS_number=298-46-4
|CAS_supplemental={{CAS|85756-57-6}}
|ATC_prefix=N03
|ATC_suffix=AF01
|ChEBI_Ref={{ebicite|correct|EBI}}
|ChEBI=3387
|PubChem=2554
|DrugBank_Ref={{drugbankcite|correct|drugbank}}
|DrugBank=DB00564
|ChemSpiderID_Ref={{chemspidercite|correct|chemspider}}
|ChemSpiderID=2457
|UNII_Ref={{fdacite|correct|FDA}}
|UNII=33CM23913M
|KEGG_Ref={{keggcite|correct|kegg}}
|KEGG=D00252
|ChEMBL_Ref={{ebicite|correct|EBI}}
|ChEMBL=108

<!--Chemical data-->
|C=15 |H=12 |N=2 |O=1
|molecular_weight=236.269&nbsp;g/mol
|smiles=c1ccc2c(c1)C=Cc3ccccc3N2C(=O)N
|InChI=1/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)
|StdInChI_Ref={{stdinchicite|correct|chemspider}}
|StdInChI=1S/C15H12N2O/c16-15(18)17-13-7-3-1-5-11(13)9-10-12-6-2-4-8-14(12)17/h1-10H,(H2,16,18)
|StdInChIKey_Ref={{stdinchicite|correct|chemspider}}
|StdInChIKey=FFGPTBGBLSHEPO-UHFFFAOYSA-N}}

英語名：mood stabilizer　独：Phasenprophylaktikum、Stimmungsstabilisierer　仏：stabilisateur de l'humeur

{{box|text=
　気分安定薬とは[[躁病]]エピソードと[[うつ病]]エピソードに対する急性期の効果と予防効果を持つ薬剤である。[[リチウム]]（lithium）、[[ラモトリギン]]（lamotrigine）、[[バルプロ酸]]（valproic acid）と[[カルバマゼピン]]（carbamazepine）が含まれる。
}}