Alfatradiolのソースを表示

{{Short description|Medication}}
{{About|17α-estradiol as a medication|its role as a hormone|17α-Estradiol}}
{{Use dmy dates|date=April 2023}}
{{Infobox drug
| Watchedfields = changed
| verifiedrevid = 458276229
| IUPAC_name = (8''R'',9''S'',13''S'',14''S'',17''R'')-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[''a'']phenanthrene-3,17-diol
| image = Alfatradiol skeletal.svg
| alt = Skeletal formula of alfatradiol
| width = 225px
| image2 = Alfatradiol 3D ball.png
| alt2 = Ball-and-stick model of the alfatradiol molecule
| width2 = 225px

<!--Clinical data-->
| tradename = Avicis, Avixis, Ell-Cranell Alpha, Pantostin
| Drugs.com = {{drugs.com|international|alfatradiol}}
| pregnancy_AU = <!-- A, B1, B2, B3, C, D, X -->
| pregnancy_US = C 
| pregnancy_category = No studies
| legal_AU = <!-- S2, S3, S4, S5, S6, S7, S8, S9 or Unscheduled-->
| legal_CA = <!-- Schedule I, II, III, IV, V, VI, VII, VIII -->
| legal_UK = <!-- GSL, P, POM, CD, or Class A, B, C -->
| legal_US = Rx-only
| legal_status = 
| routes_of_administration = [[Topical]]
| class = [[Estrogen (medication)|Estrogen]]; [[5α-Reductase inhibitor]]

<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = 
| metabolism = 
| elimination_half-life = 
| excretion =

<!--Identifiers-->
| CAS_number_Ref = {{cascite|correct|??}}
| CAS_number = 57-91-0
| ATC_prefix = None
| ChEMBL_Ref = {{ebicite|correct|EBI}}
| ChEMBL = 286452
| ChEBI_Ref = {{ebicite|correct|EBI}}
| ChEBI = 17160
| PubChem = 68570
| ChemSpiderID_Ref = {{chemspidercite|correct|chemspider}}
| ChemSpiderID = 61840
| UNII_Ref = {{fdacite|correct|FDA}}
| UNII = 3VQ38D63M7
| synonyms = 17α-Estradiol; 17-Epiestradiol; MX-4509; Estra-1,3,5(10)-triene-3,17α-diol; β-Estradiol (obsolete, misleading)<ref name="Elks2014" />

<!--Chemical data-->
| C=18 | H=24 | O=2 
| SMILES = OC1CCC3C1(C)CCC(c2cc4)C3CCc2cc4O
| StdInChI_Ref = {{stdinchicite|correct|chemspider}}
| StdInChI = 1S/C18H24O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3,5,10,14-17,19-20H,2,4,6-9H2,1H3/t14-,15-,16+,17-,18+/m1/s1
| StdInChIKey_Ref = {{stdinchicite|correct|chemspider}}
| StdInChIKey = VOXZDWNPVJITMN-SFFUCWETSA-N
}}

'''Alfatradiol''', also known as '''17α-estradiol''' and sold under the brand names '''Avicis''', '''Avixis''', '''Ell-Cranell Alpha''', and '''Pantostin''', is a weak [[estrogen (medication)|estrogen]] and [[5α-reductase inhibitor]] medication which is used [[topical medication|topically]] in the treatment of [[pattern hair loss]] (androgenic alopecia or pattern baldness) in men and women.<ref name="Elks2014">{{cite book|author=J. Elks|title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA897|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|page=897}}</ref><ref name="Drugs.com">{{cite web | title = Alfatradiol | url = https://www.drugs.com/international/alfatradiol.html | work = Drugs.com International }}</ref><ref name="Hunnius" /><ref name="WHO" /> It is a [[stereoisomerism|stereoisomer]] of the [[endogeny (biology)|endogenous]] [[steroid hormone]] and estrogen [[17β-estradiol]] (or simply [[estradiol (medication)|estradiol]]).<ref name="Elks2014" />