Moxestrolのソースを表示

{{Short description|Chemical compound}}
{{Drugbox
| Verifiedfields = 
| Watchedfields = 
| verifiedrevid = 
| IUPAC_name = (8''S'',9''S'',11''S'',13''S'',14''S'',17''R'')-17-ethynyl-11-methoxy-13-methyl-7,8,9,11,12,14,15,16-octahydro-6''H''-cyclopenta[''a'']phenanthrene-3,17-diol
| image = Moxestrol_structure.svg
| width = 225px
| image2 = Moxestrol molecule ball.png
| width2 = 235px

<!--Clinical data-->
| tradename = Surestryl
| pregnancy_category = X (Contraindicated)
| legal_status = Rx-only
| routes_of_administration = [[Oral administration|By mouth]]
| class = [[Estrogen (medication)|Estrogen]]; [[Estrogen ether]]

<!--Pharmacokinetic data-->
| bioavailability = 33%<ref name="SalmonCoussediere1983" />
| protein_bound = Minimal<ref name="SalmonCoussediere1983" />
| metabolism = [[Liver]]<ref name="LiNandi2012" />
| elimination_half-life = 8.2 hours<ref name="SalmonCoussediere1983">{{cite journal | vauthors = Salmon J, Coussediere D, Cousty C, Raynaud JP | title = Pharmacokinetics and metabolism of moxestrol in animals--rat, dog and monkey | journal = Journal of Steroid Biochemistry | volume = 19 | issue = 2 | pages = 1223–1234 | date = August 1983 | pmid = 6887930 | doi = 10.1016/0022-4731(83)90421-1 }}</ref>
| excretion = 

<!--Identifiers-->
| CAS_number_Ref = 
| CAS_number = 34816-55-2
| CAS_supplemental = 
| ATC_prefix = G03
| ATC_suffix = CB04
| PubChem = 11954041
| DrugBank_Ref = 
| DrugBank = 
| ChemSpiderID_Ref = 
| ChemSpiderID = 10128336
| UNII = 6923NT44OW
| KEGG = C14757
| ChEBI = 34857
| ChEMBL = 1628161
| synonyms = R-2858, RU-2858, NSC-118191; 11β-Methoxy-17α-ethynylestradiol; 11β-MeO-EE 11β-Methoxy-17α-ethynylestra-1,3,5(10)-triene-3,17β-diol

<!--Chemical data-->
| C=21 | H=26 | O=3
| SMILES = CC12CC(C3C(C1CCC2(C#C)O)CCC4=C3C=CC(=C4)O)OC
| StdInChI = 1S/C21H26O3/c1-4-21(23)10-9-17-16-7-5-13-11-14(22)6-8-15(13)19(16)18(24-3)12-20(17,21)2/h1,6,8,11,16-19,22-23H,5,7,9-10,12H2,2-3H3/t16-,17-,18-,19+,20-,21-/m0/s1
| StdInChIKey = MTMZZIPTQITGCY-OLGWUGKESA-N
}}

'''Moxestrol''', sold under the brand name '''Surestryl''', is an [[estrogen (medication)|estrogen]] medication which has been used in [[Europe]] for the treatment of [[menopausal symptoms]] and [[menstrual disorder]]s.<ref name="Elks2014">{{cite book| vauthors = Elks J |title=The Dictionary of Drugs: Chemical Data: Chemical Data, Structures and Bibliographies|url=https://books.google.com/books?id=0vXTBwAAQBAJ&pg=PA841|date=14 November 2014|publisher=Springer|isbn=978-1-4757-2085-3|pages=841–}}</ref><ref name="MortonHall1999">{{cite book| vauthors = Morton IK, Hall JM |title=Concise Dictionary of Pharmacological Agents: Properties and Synonyms|url=https://books.google.com/books?id=mqaOMOtk61IC&pg=PA186|date=31 October 1999|publisher=Springer Science & Business Media|isbn=978-0-7514-0499-9|pages=186–}}</ref><ref name="LiNandi2012">{{cite book| vauthors = Li JJ, Nandi S, Li SA |title=Hormonal Carcinogenesis: Proceedings of the First International Symposium|url=https://books.google.com/books?id=oPgxBwAAQBAJ&pg=PT184|date=6 December 2012|publisher=Springer Science & Business Media|isbn=978-1-4613-9208-8|pages=184–}}</ref><ref name="Nunn1992">{{cite book| vauthors = Nunn AD |title=Radiopharmaceuticals: Chemistry and Pharmacology|url=https://books.google.com/books?id=iWrTdGUbjzEC&pg=PA342|date=19 June 1992|publisher=CRC Press|isbn=978-0-8247-8624-3|pages=342–}}</ref><ref name="MartindaleSciences1993">{{cite book|author1=William Martindale|author2=Royal Pharmaceutical Society of Great Britain. Dept. of Pharmaceutical Sciences|title=The Extra Pharmacopoeia|url=https://books.google.com/books?id=EGZWAAAAYAAJ|year=1993|publisher=Pharmaceutical Press|isbn=978-0-85369-300-0|page=1188|quote=Moxestrol is a synthetic oestrogen with actions and uses similar to thosre described for the oestrogens in general. Moxestrol is reponed to have a prolonged duration of action. It has been given by mouth in the treatment of menopausal, postmenopausal, and menstrual symptoms. Dose have ranged from 50 to 100 μg weekly for long-term therapy to 25 to 250 μg daily for short-term use.}}</ref> It is taken [[oral administration|by mouth]].<ref name="MartindaleSciences1993" /> In addition to its use as a medication, moxestrol has been used in [[scientific research]] as a [[radioligand]] of the [[estrogen receptor]].<ref name="pmid679210">{{cite journal | vauthors = Raynaud JP, Martin PM, Bouton MM, Ojasoo T | title = 11beta-Methoxy-17-ethynyl-1,3,5(10)-estratriene-3,17beta-diol (moxestrol), a tag for estrogen receptor binding sites in human tissues | journal = Cancer Research | volume = 38 | issue = 9 | pages = 3044–3050 | date = September 1978 | pmid = 679210 | url = http://cancerres.aacrjournals.org/content/38/9/3044.long }}</ref>