テンプレート:Selected biological properties of endogenous estrogens in ratsのソースを表示

{| class="wikitable sortable mw-collapsible" style="text-align:left; margin-left:auto; margin-right:auto; border:none;"
|+ class="nowrap" | {{Navbar|Selected biological properties of endogenous estrogens in rats|mini=y}} Selected biological properties of endogenous <noinclude>[[estrogen (medication)|estrogen]]s</noinclude><includeonly>estrogens</includeonly> in rats
|-
! {{No selflink|Estrogen (medication)|Estrogen}} !! {{abbrlink|ER|Estrogen receptor}} {{Abbrlink|RBA|relative binding affinity}} (%) !! [[Uterus|Uterine weight]] (%) !! [[Uterotrophy]] !! {{Abbrlink|LH|Luteinizing hormone}} levels (%) !! {{Abbrlink|SHBG|Sex hormone-binding globulin}} {{Abbrlink|RBA|relative binding affinity}} (%)
|-
| Control || – || 100 || – || 100 || –
|-
| {{No selflink|Estradiol (medication)|Estradiol (E2)}} || 100 || 506 ± 20 || +++ || 12–19 || 100
|-
| {{No selflink|Estrone (medication)|Estrone (E1)}} || 11 ± 8 || 490 ± 22 || +++ || ? || 20
|-
| {{No selflink|Estriol (medication)|Estriol (E3)}} || 10 ± 4 || 468 ± 30 || +++ || 8–18 || 3
|-
| {{No selflink|Estetrol (medication)|Estetrol (E4)}} || 0.5 ± 0.2 || ? || Inactive || ? || 1
|-
| {{No selflink|Alfatradiol|17α-Estradiol}} || 4.2 ± 0.8 || ? || ? || ? || ?
|-
| {{No selflink|2-Hydroxyestradiol}} || 24 ± 7 || 285 ± 8 || +<sup>b</sup> || 31–61 || 28
|-
| {{No selflink|2-Methoxyestradiol}} || 0.05 ± 0.04 || 101 || Inactive || ? || 130
|-
| {{No selflink|4-Hydroxyestradiol}} || 45 ± 12 || ? || ? || ? || ?
|-
| {{No selflink|4-Methoxyestradiol}} || 1.3 ± 0.2 || 260 || ++ || ? || 9
|-
| {{No selflink|4-Fluoroestradiol}}<sup>a</sup> || 180 ± 43 || ? || +++ || ? || ?
|-
| {{No selflink|2-Hydroxyestrone}} || 1.9 ± 0.8 || 130 ± 9 || Inactive || 110–142 || 8
|-
| {{No selflink|2-Methoxyestrone}} || 0.01 ± 0.00 || 103 ± 7 || Inactive || 95–100 || 120
|-
| {{No selflink|4-Hydroxyestrone}} || 11 ± 4 || 351 || ++ || 21–50 || 35
|-
| {{No selflink|4-Methoxyestrone}} || 0.13 ± 0.04 || 338 || ++ || 65–92 || 12
|-
| {{No selflink|16α-Hydroxyestrone}} || 2.8 ± 1.0 || 552 ± 42 || +++ || 7–24 || <0.5
|-
| {{No selflink|2-Hydroxyestriol}} || 0.9 ± 0.3 || 302 || +<sup>b</sup> || ? || ?
|-
| {{No selflink|2-Methoxyestriol}} || 0.01 ± 0.00 || ? || Inactive || ? || 4
|- class="sortbottom"
| colspan="6" style="width: 1px; background-color:#eaecf0; text-align: center;" | '''Notes:''' Values are mean ± SD or range. {{Abbr|ER|estrogen receptor}} {{abbr|RBA|Relative binding affinity}} = [[Relative binding affinity]] to [[estrogen receptor]]s of rat [[uterus|uterine]] [[cytosol]]. Uterine weight = Percentage change in uterine wet weight of [[ovariectomy|ovariectomized]] rats after 72&nbsp;hours with continuous administration of 1&nbsp;μg/hour via [[subcutaneous implant|subcutaneously implanted]] [[osmotic pump]]s. {{Abbr|LH|Luteinizing hormone}} levels = [[Luteinizing hormone]] levels relative to baseline of ovariectomized rats after 24 to 72&nbsp;hours of continuous administration via subcutaneous implant. '''Footnotes:''' <sup>a</sup> = [[Synthetic compound|Synthetic]] (i.e., not [[endogenous]]). <sup>b</sup> = Atypical uterotrophic effect which plateaus within 48&nbsp;hours (estradiol's uterotrophy continues linearly up to 72&nbsp;hours). '''Sources:''' <noinclude><ref name="pmid178074">{{cite journal | vauthors = Martucci C, Fishman J | title = Uterine estrogen receptor binding of catecholestrogens and of estetrol (1,3,5(10)-estratriene-3,15alpha,16alpha,17beta-tetrol) | journal = Steroids | volume = 27 | issue = 3 | pages = 325–333 | date = March 1976 | pmid = 178074 | doi = 10.1016/0039-128x(76)90054-4 | s2cid = 54412821 }}</ref><ref name="pmid590186">{{cite journal | vauthors = Martucci C, Fishman J | title = Direction of estradiol metabolism as a control of its hormonal action--uterotrophic activity of estradiol metabolites | journal = Endocrinology | volume = 101 | issue = 6 | pages = 1709–1715 | date = December 1977 | pmid = 590186 | doi = 10.1210/endo-101-6-1709 }}</ref><ref name="pmid724350">{{cite journal | vauthors = Fishman J, Martucci C | title = Differential biological activity of estradiol metabolites | journal = Pediatrics | volume = 62 | issue = 6 Pt 2 | pages = 1128–1133 | date = December 1978 | doi = 10.1542/peds.62.6.1128 | pmid = 724350 | s2cid = 29609115 | url = https://pediatrics.aappublications.org/content/62/6/1128 }}</ref><ref name="pmid499073">{{cite journal | vauthors = Martucci CP, Fishman J | title = Impact of continuously administered catechol estrogens on uterine growth and luteinizing hormone secretion | journal = Endocrinology | volume = 105 | issue = 6 | pages = 1288–1292 | date = December 1979 | pmid = 499073 | doi = 10.1210/endo-105-6-1288 }}</ref><ref name="FishmanMartucci1980a">{{cite book| vauthors = Fishman J, Martucci CP |chapter=New Concepts of Estrogenic Activity: the Role of Metabolites in the Expression of Hormone Action|pages=43–52|doi=10.1007/978-94-011-7230-1_5| veditors = Pasetto N, Paoletti R, Ambrus JL |title=The Menopause and Postmenopause|isbn=978-94-011-7232-5|year=1980}}</ref><ref name="pmid7190977">{{cite journal | vauthors = Fishman J, Martucci C | title = Biological properties of 16 alpha-hydroxyestrone: implications in estrogen physiology and pathophysiology | journal = The Journal of Clinical Endocrinology and Metabolism | volume = 51 | issue = 3 | pages = 611–615 | date = September 1980 | pmid = 7190977 | doi = 10.1210/jcem-51-3-611 }}</ref><ref name="pmid6310247">{{cite journal | vauthors = Martucci CP | title = The role of 2-methoxyestrone in estrogen action | journal = Journal of Steroid Biochemistry | volume = 19 | issue = 1B | pages = 635–638 | date = July 1983 | pmid = 6310247 | doi = 10.1016/0022-4731(83)90229-7 }}</ref><ref name="FishmanMartucci1980b">{{cite book | vauthors = Fishman J, Martucci C | chapter = Dissociation of biological activities in metabolites of estradiol | pages = 131–145 | veditors = McLachlan JA | title = Estrogens in the Environment: Proceedings of the Symposium on Estrogens in the Environment, Raleigh, North Carolina, U.S.A., September 10-12, 1979 | year = 1980 | isbn = 9780444003720 | publisher = Elsevier | url = https://books.google.com/books?id=eu5qAAAAMAAJ}}</ref><ref name="pmid16112947">{{cite journal | vauthors = Kuhl H | title = Pharmacology of estrogens and progestogens: influence of different routes of administration | journal = Climacteric | volume = 8 Suppl 1 | pages = 3–63 | date = August 2005 | pmid = 16112947 | doi = 10.1080/13697130500148875 | s2cid = 24616324 }}</ref></noinclude><includeonly>See template.</includeonly>
|}<!--

--><noinclude>{{Documentation|content=
== See also ==
* [[Estrogen (medication)#Pharmacology|Estrogen (medication) § Pharmacology]]
* [[Template:Affinities of estrogen receptor ligands for the ERα and ERβ]]
* [[Template:Relative affinities of estrogens for steroid hormone receptors and blood proteins]]

== References ==
{{Reflist}}
}}
[[Category:Estrogens]]
[[Category:Medication templates]]
[[Category:Templates that generate named references]]
</noinclude>