Estradiol 17β-acetateのソースを表示

{{Short description|Chemical compound}}
{{Distinguish|Estradiol acetate}}
{{Drugbox
| Verifiedfields = 
| Watchedfields = 
| verifiedrevid = 
| IUPAC_name = [(8''R'',9''S'',13''S'',14''S'',17''S'')-3-hydroxy-13-methyl-6,7,8,9,11,12,14,15,16,17-decahydrocyclopenta[''a'']phenanthren-17-yl] acetate
| image = estradiol acetate.svg
| width = 

<!--Clinical data-->
| tradename = 
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X -->
| pregnancy_US = <!-- A / B / C / D / X -->
| pregnancy_category = 
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 -->
| legal_CA = 
| legal_UK = 
| legal_US = 
| legal_status = 
| routes_of_administration = 
| class = [[Estrogen (medication)|Estrogen]]; [[Estrogen ester]]

<!--Pharmacokinetic data-->
| bioavailability = 
| protein_bound = 
| metabolism = 
| elimination_half-life = 
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<!-- Identifiers -->
| CAS_number_Ref = 
| CAS_number = 1743-60-8
| CAS_supplemental = 
| ATC_prefix = 
| ATC_suffix = 
| ATC_supplemental = 
| PubChem = 6852404
| IUPHAR_ligand = 
| DrugBank_Ref = 
| DrugBank = 
| ChemSpiderID_Ref = 
| ChemSpiderID = 5254726
| UNII = 2VM9HO33RU
| KEGG = C15228
| ChEBI = 79735
| ChEMBL = 1611800
| synonyms = 

<!--Chemical data-->
| C=20 | H=26 | O=3
| SMILES = CC(=O)O[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=C3C=CC(=C4)O)C
| StdInChI_Ref = 
| StdInChI = 1S/C20H26O3/c1-12(21)23-19-8-7-18-17-5-3-13-11-14(22)4-6-15(13)16(17)9-10-20(18,19)2/h4,6,11,16-19,22H,3,5,7-10H2,1-2H3/t16-,17-,18+,19+,20+/m1/s1
| StdInChIKey_Ref = 
| StdInChIKey = QAHOQNJVHDHYRN-SLHNCBLASA-N
}}

'''Estradiol 17β-acetate''' is an [[estrogen (medication)|estrogen]] and an [[estrogen ester]]—specifically, the C17β [[acetate]] [[ester]] of [[estradiol (medication)|estradiol]]—which was never marketed.<ref name="pmid13531579">{{cite journal | vauthors = Junkmann K, Witzel H | title = Chemie und Pharmakologie von Steroidhormon-Estern | trans-title = Chemistry and pharmacology of steroid hormone esters | language = de | journal = Z Vitam Horm Fermentforsch | volume = 9 | issue = 1–2 | pages = 97–143 contd | date = 1957 | pmid = 13531579 }}</ref><ref name="pmid6705734">{{cite journal | vauthors = Janocko L, Larner JM, Hochberg RB | title = The interaction of C-17 esters of estradiol with the estrogen receptor | journal = Endocrinology | volume = 114 | issue = 4 | pages = 1180–6 | date = April 1984 | pmid = 6705734 | doi = 10.1210/endo-114-4-1180 }}</ref><ref name="pmid21038436">{{cite journal | vauthors = Mu Y, Peng S, Zhang A, Wang L | title = Role of pocket flexibility in the modulation of estrogen receptor alpha by key residue arginine 394 | journal = Environ. Toxicol. Chem. | volume = 30 | issue = 2 | pages = 330–6 | date = February 2011 | pmid = 21038436 | doi = 10.1002/etc.389 | bibcode = 2011EnvTC..30..330M | s2cid = 22116062 }}</ref> It is the C17β [[positional isomer]] of the better-known and clinically used [[estradiol ester]] [[estradiol acetate]] (estradiol 3-acetate; Femtrace).<ref name="pmid13531579" />

{{Affinities and estrogenic potencies of estrogen esters and ethers at the estrogen receptors}}

==See also==
* [[List of estrogen esters#Estradiol esters|List of estrogen esters § Estradiol esters]]

==References==
{{Reflist}}


{{Estrogen receptor modulators}}

[[Category:Abandoned drugs]]
[[Category:Acetate esters]]
[[Category:Estradiol esters]]
[[Category:Secondary alcohols]]
[[Category:Synthetic estrogens]]


{{Steroid-stub}}
{{Genito-urinary-drug-stub}}