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Β-Zearalenol - 版の履歴
2026-04-12T11:39:23Z
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WikiSysop: 1版 をインポートしました
2025-03-18T10:35:26Z
<p>1版 をインポートしました</p>
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https://bsd.neuroinf.jp/w/index.php?title=%CE%92-Zearalenol&diff=49975&oldid=prev
2023年9月15日 (金) 21:20にbsd>Hyphenation Expertによる
2023-09-15T21:20:24Z
<p></p>
<p><b>新規ページ</b></p><div>{{Short description|Chemical compound}}<br />
{{lowercase title}}<br />
{{Drugbox<br />
| Verifiedfields = <br />
| Watchedfields = <br />
| verifiedrevid = <br />
| drug_name = β-Zearalenol<br />
| IUPAC_name = (2''E'',7''S'',11''S'')-7,15,17-trihydroxy-11-methyl-12-oxabicyclo[12.4.0]octadeca-1(18),2,14,16-tetraen-13-one<br />
| image = Beta Zearalenol.svg<br />
| width =<br />
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<!--Clinical data--><br />
| tradename = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| pregnancy_category = <br />
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
| legal_CA = <br />
| legal_UK = <br />
| legal_US = <br />
| legal_status = <br />
| routes_of_administration =<br />
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<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
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<!-- Identifiers --><br />
| CAS_number_Ref = <br />
| CAS_number = 71030-11-0<br />
| CAS_supplemental = <br />
| ATC_prefix = <br />
| ATC_suffix = <br />
| ATC_supplemental = <br />
| PubChem = 6437352<br />
| IUPHAR_ligand = <br />
| DrugBank_Ref = <br />
| DrugBank = <br />
| ChemSpiderID_Ref = <br />
| ChemSpiderID = 5908979<br />
| UNII = 35E809PP7O<br />
| KEGG = C14751<br />
| ChEBI = 35072<br />
| ChEMBL =<br />
<br />
<!--Chemical data--><br />
| C=18 | H=24 | O=5<br />
| SMILES = C[C@H]1CCC[C@H](CCC/C=C/C2=CC(=CC(=C2C(=O)O1)O)O)O<br />
| StdInChI_Ref = <br />
| StdInChI = 1S/C18H24O5/c1-12-6-5-9-14(19)8-4-2-3-7-13-10-15(20)11-16(21)17(13)18(22)23-12/h3,7,10-12,14,19-21H,2,4-6,8-9H2,1H3/b7-3+/t12-,14-/m0/s1<br />
| StdInChIKey_Ref = <br />
| StdInChIKey = FPQFYIAXQDXNOR-PMRAARRBSA-N<br />
| synonyms = beta-Zearalenol; beta-''trans''-Zearalenol<br />
}}<br />
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'''β-Zearalenol''' is a [[nonsteroidal]] [[estrogen]] of the [[resorcylic acid lactone]] group related to [[mycoestrogen]]s found in ''[[Fusarium|Fusarium spp]]''.<ref name="Chelkowski2014">{{cite book | vauthors = Bottalico A, Logrieco A, Visconti A | chapter = Fusarium species and their mycotoxins in infected cereals in the field and in stored grains | title = Fusarium: Mycotoxins, Taxonomy, Pathogenicity | date = January 1989 | pages = 85–119 | veditors = Chelkowski J | chapter-url=https://books.google.com/books?id=_1KeBQAAQBAJ&pg=PA85 |publisher=Elsevier Science |isbn=978-1-4832-9785-9 }}</ref> It is the β [[epimer]] of [[α-zearalenol]] and along with α-zearalenol is a major [[metabolite]] of [[zearalenone]] formed mainly in the [[liver]] but also to a lesser extent in the [[intestine]]s during [[first-pass metabolism]].<ref name="MaganOlsen2004">{{cite book | vauthors = Alldrick AJ, Hajšelová M | chapter = Zearalenone | title = Mycotoxins in Food: Detection and Control | date = January 2004 | pages = 353–366 | publisher = Woodhead Publishing | veditors = Magan N, Olsen M | chapter-url=https://books.google.com/books?id=CZ3iEhPeejoC&pg=PA356 |isbn=978-1-85573-733-4 }}</ref><ref name="Eriksen1998">{{cite book | chapter = Zearalenone | vauthors = Eriksen GS, Alexander J |title=Fusarium Toxins in Cereals: A Risk Assessment| chapter-url=https://books.google.com/books?id=jU5Wx8LkZHUC&pg=PA61|year=1998|publisher=Nordic Council of Ministers|isbn=978-92-893-0149-7|pages=61–}}</ref> A relatively high proportion of α-zearalenol is formed from zearalenone compared to β-zearalenol in humans.<ref name="Eriksen1998" /> β-Zearalenol is about the same or slightly less potent as an estrogen relative to zearalenone.<ref name="Chelkowski2014" /><br />
<br />
==See also==<br />
* [[Taleranol]] (β-zearalanol)<br />
* [[Zeranol]] (α-zearalanol)<br />
* [[Zearalanone]]<br />
<br />
==References==<br />
{{reflist|30em}}<br />
<br />
{{Estrogen receptor modulators}}<br />
<br />
{{DEFAULTSORT:Zearalenol, alpha-}}<br />
[[Category:Lactones]]<br />
[[Category:Mycoestrogens]]<br />
[[Category:Mycotoxins]]<br />
[[Category:Resorcinols]]</div>
bsd>Hyphenation Expert