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{{Annotated image 4
| image = Estradiol metabolism structures.svg
| class = skin-invert
| image-width = 485
| width = 485
| height = 400
| image-left = 0
| image-top = 0
| link =
| align = {{{align|center}}}
| caption = {{{caption|'''Description:''' The [[metabolic pathway]]s involved in the [[metabolism]] of {{No selflink|estradiol}} and other [[natural product|natural]] {{No selflink|estrogen}}s (e.g., {{No selflink|estrone}}, {{No selflink|estriol}}) in humans. In addition to the [[biotransformation|metabolic transformation]]s shown in the diagram, [[conjugation (biochemistry)|conjugation]] (e.g., [[sulfation]] and [[glucuronidation]]) occurs in the case of estradiol and [[metabolite]]s of estradiol that have one or more available [[hydroxyl group|hydroxyl]] (–OH) [[functional group|group]]s. '''Sources:''' <noinclude><ref name="The Menopause">{{cite book | veditors=Buchsbaum HJ | title=The Menopause (Clinical Perspectives in Obstetrics and Gynecology) | date=2012 | publisher=Springer Science & Business Media | location=New York, NY | isbn=9781461255253 | page=64 | url=https://books.google.com/books?id=z0LuBwAAQBAJ&pg=PA64%7Cdate=6}}</ref><ref name="Pharmacology of estrogens and progestogens">{{cite journal | vauthors = Kuhl H | title = Pharmacology of estrogens and progestogens: influence of different routes of administration | journal = Climacteric : The Journal of the International Menopause Society | volume = 8 Suppl 1 | pages = 3–63 | date = August 2005 | pmid = 16112947 | doi = 10.1080/13697130500148875 | s2cid = 24616324 }}</ref><ref name="Dorfman1961">{{cite book|title=Radioactive Isotopes in Physiology Diagnostics and Therapy|last1=Dorfman|first1=Ralph I.|chapter=Steroid Hormone Metabolism|year=1961|pages=1223–1241|doi=10.1007/978-3-642-49761-2_39|isbn=978-3-642-49477-2 }}</ref><ref name="Estrone sulfotransferase">{{cite website|title=EC 2.4.1.17 – glucuronosyltransferase and Organism(s) Homo sapiens|url=https://www.brenda-enzymes.org/enzyme.php?ecno=2.4.1.17&Suchword=estrone&reference=&UniProtAcc=&organism%5B%5D=Homo+sapiens|website=BRENDA|publisher=Technische Universität Braunschweig|access-date=10 August 2018|date=January 2018}}</ref></noinclude><includeonly>See template page.</includeonly>}}}

| alt = Graphic of the metabolic pathways of estradiol in humans
| header = {{Navbar|Estradiol metabolism|mini=y}} {{{header|[[Metabolic pathway]]s of {{no selflink|estradiol}} in humans}}}
| header_background = light-dark(aliceblue,var(--background-color-neutral))
| annot-font-size = 13
| annotations =


{{Annotation|40|68|{{if pagename
|Estradiol='''Estradiol'''
|Pharmacology of estradiol='''[[Estradiol]]'''
|Estradiol (medication)='''[[Estradiol]]'''
|Estrogen='''[[Estradiol]]'''
|Estrogen (medication)='''[[Estradiol]]'''
|other=[[Estradiol]]
}}
}}
{{Annotation|186|68|{{if pagename
|Estrone sulfate='''Estrone sulfate'''
|Estrone sulfate (medication)='''[[Estrone sulfate]]'''
|other=[[Estrone sulfate]]
}}
}}
{{Annotation|338|83|{{if pagename
|Estrone glucuronide='''Estrone glucuronide'''
|other=[[Estrone glucuronide]]
}}
}}


{{Annotation|10|180|{{if pagename
|2-Hydroxyestrone='''2-Hydroxyestrone'''
|other=[[2-Hydroxyestrone]]
}}
}}
{{Annotation|210|180|{{if pagename
|Estrone='''Estrone'''
|Estrone (medication)='''[[Estrone]]'''
|Estrogen='''[[Estrone]]'''
|Estrogen (medication)='''[[Estrone]]'''
|other=[[Estrone]]
}}
}}
{{Annotation|365|186|{{if pagename
|4-Hydroxyestrone='''4-Hydroxyestrone'''
|other=[[4-Hydroxyestrone]]
}}
}}


{{Annotation|10|280|{{if pagename
|2-Methoxyestrone='''2-Methoxyestrone'''
|other=[[2-Methoxyestrone]]
}}
}}
{{Annotation|180|280|{{if pagename
|16α-Hydroxyestrone='''16α-Hydroxyestrone'''
|other=[[16α-Hydroxyestrone]]
}}
}}
{{Annotation|365|295|{{if pagename
|4-Methoxyestrone='''4-Methoxyestrone'''
|other=[[4-Methoxyestrone]]
}}
}}


{{Annotation|25|384|{{if pagename
|17-Epiestriol='''17-Epiestriol'''
|other=[[17-Epiestriol]]
}}
}}
{{Annotation|210|384|{{if pagename
|Estriol='''Estriol'''
|Estriol (medication)='''[[Estriol]]'''
|Estrogen='''[[Estriol]]'''
|Estrogen (medication)='''[[Estriol]]'''
|other=[[Estriol]]
}}
}}
{{Annotation|375|384|{{if pagename
|16-Epiestriol='''16-Epiestriol'''
|other=[[16-Epiestriol]]
}}
}}




{{Annotation|150|84|[[17β-Hydroxysteroid dehydrogenase#Overview|17β-HSD]]|font-size=12|text-align=left}}

{{Annotation|192|100|[[Estrone sulfotransferase#Types|EST]]|font-size=12|text-align=right}}

{{Annotation|225|100|[[Steroid sulfatase|STS]]|font-size=12}}

{{Annotation|272|76|[[UGT1A3|UGT1A3]] [[UGT1A9|UGT1A9]]|font-size=12}}




{{Annotation|130|134|[[CYP450|CYP450]]|font-size=12}}

{{Annotation|296|134|[[CYP450|CYP450]]|font-size=12}}




{{Annotation|16|206|[[Catechol-O-methyltransferase|COMT]]|font-size=12|text-align=right}}

{{Annotation|228|198|[[CYP450|CYP450]]|font-size=12|text-align=right}}

{{Annotation|364|206|[[Catechol-O-methyltransferase|COMT]]|font-size=12|text-align=right}}




{{Annotation|128|298|unidentified|font-size=12|text-align=left}}

{{Annotation|226|300|[[17β-Hydroxysteroid dehydrogenase|17β-HSD]]|font-size=12}}

{{Annotation|296|298|unidentified|font-size=12|text-align=right}}

}}
<noinclude>{{Documentation}}</noinclude>

テンプレート:Estradiol metabolism - 版の履歴

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bsd>Arthurfragoso: dark mode fix

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