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17α-Dihydroequilin - 版の履歴
2026-04-15T09:44:59Z
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2025-03-18T10:26:46Z
<p>1版 をインポートしました</p>
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bsd>OAbot: Open access bot: doi added to citation with #oabot.
2023-01-29T15:02:15Z
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<p><b>新規ページ</b></p><div>{{Short description|Chemical compound}}<br />
{{Distinguish|17β-Dihydroequilin|17α-Dihydroequilenin|17β-Dihydroequilenin}}<br />
{{Drugbox<br />
| Verifiedfields = <br />
| Watchedfields = <br />
| verifiedrevid = <br />
| IUPAC_name = (9''S'',13''S'',14''S'',17''R'')-13-methyl-6,9,11,12,14,15,16,17-octahydrocyclopenta[''a'']phenanthrene-3,17-diol<br />
| image = 17α Dihydroequilin.svg<br />
| width = 225px<br />
<br />
<!--Clinical data--><br />
| tradename = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| pregnancy_category = <br />
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
| legal_CA = <br />
| legal_UK = <br />
| legal_US = <br />
| legal_status = <br />
| routes_of_administration = [[Oral administration|By mouth]]<br />
| class = [[Estrogen (medication)|Estrogen]]<br />
<br />
<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion = <br />
<br />
<!--Identifiers--><br />
| CAS_number_Ref = <br />
| CAS_number = 651-55-8<br />
| CAS_supplemental = <br />
| ATC_prefix = G03<br />
| ATC_suffix = CA57<br />
| PubChem = 9547222<br />
| DrugBank_Ref = <br />
| DrugBank = <br />
| ChemSpiderID_Ref = <br />
| ChemSpiderID = 7826162<br />
| UNII = 48P73794OJ<br />
| synonyms = α-Dihydroequilin; 7-Dehydro-17α-estradiol; Estra-1,3,5(10),7-tetraen-3,17α-diol<br />
<br />
<!--Chemical data--><br />
| C=18 | H=22 | O=2<br />
| SMILES = CC12CCC3C(=CCC4=C3C=CC(=C4)O)C1CCC2O<br />
| StdInChI_Ref = <br />
| StdInChI = 1S/C18H22O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h3-5,10,14,16-17,19-20H,2,6-9H2,1H3/t14-,16+,17-,18+/m1/s1<br />
| StdInChIKey_Ref = <br />
| StdInChIKey = NLLMJANWPUQQTA-SPUZQDLCSA-N<br />
}}<br />
<br />
'''17α-Dihydroequilin''', or '''α-dihydroequilin''', also known as '''7-dehydro-17α-estradiol''', as well as '''estra-1,3,5(10),7-tetraene-3,17α-diol''', is a [[natural product|naturally occurring]] [[steroid]]al [[estrogen (medication)|estrogen]] found in [[equine|horse]]s which is closely related to [[equilin]], [[equilenin]], and [[17α-estradiol]].<ref name="FritzSperoff2012">{{cite book| vauthors = Fritz MA, Speroff L |title=Clinical Gynecologic Endocrinology and Infertility|url=https://books.google.com/books?id=KZLubBxJEwEC&pg=PA751|date=28 March 2012|publisher=Lippincott Williams & Wilkins|isbn=978-1-4511-4847-3|pages=751–}}</ref><ref name="HumansOrganization2007">{{cite book|author1=IARC Working Group on the Evaluation of Carcinogenic Risks to Humans|author2=World Health Organization|author3=International Agency for Research on Cancer|title=Combined Estrogen-progestogen Contraceptives and Combined Estrogen-progestogen Menopausal Therapy|url=https://books.google.com/books?id=aGDU5xibtNgC&pg=PA378|year=2007|publisher=World Health Organization|isbn=978-92-832-1291-1|pages=378–}}</ref> The compound, as the 3-[[sulfate]] [[ester]] [[sodium]] [[salt (chemistry)|salt]], is present in [[conjugated estrogens]] (Premarin), a [[pharmaceutical drug|pharmaceutical]] [[extract]] of the [[urine]] of [[pregnancy|pregnant]] [[mare]]s, and is the third highest quantity constituent in the formulation (13.8%).<ref name="FritzSperoff2012" /> The compound has been studied clinically.<ref name="WilcoxStanczyk1996">{{cite journal | vauthors = Wilcox JG, Stanczyk FZ, Morris RS, Gentzschein E, Lobo RA | title = Biologic effects of 17 alpha-dihydroequilin sulfate | journal = Fertility and Sterility | volume = 66 | issue = 5 | pages = 748–52 | date = November 1996 | pmid = 8893678 | doi = 10.1016/S0015-0282(16)58629-4 | doi-access = free }}</ref><br />
<br />
== See also ==<br />
* [[List of estrogens#Equine estrogens|List of estrogens § Equine estrogens]]<br />
<br />
== References ==<br />
{{Reflist}}<br />
<br />
{{Estrogens and antiestrogens}}<br />
{{Estrogen receptor modulators}}<br />
<br />
{{DEFAULTSORT:Dihydroequilin, 17α-}}<br />
<br />
[[Category:Secondary alcohols]]<br />
[[Category:Estranes]]<br />
[[Category:Estrogens]]<br />
<br />
{{Genito-urinary-drug-stub}}<br />
{{Steroid-stub}}</div>
bsd>OAbot