https://bsd.neuroinf.jp/w/index.php?action=history&feed=atom&title=17%CE%B2-Dihydroequilenin
17β-Dihydroequilenin - 版の履歴
2026-04-15T06:05:14Z
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WikiSysop: 1版 をインポートしました
2025-03-18T10:26:47Z
<p>1版 をインポートしました</p>
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WikiSysop
https://bsd.neuroinf.jp/w/index.php?title=17%CE%B2-Dihydroequilenin&diff=49697&oldid=prev
2025年1月15日 (水) 16:38にbsd>Fswitzer4による
2025-01-15T16:38:10Z
<p></p>
<p><b>新規ページ</b></p><div>{{Short description|Chemical compound}}<br />
{{cs1 config|name-list-style=vanc}}<br />
{{Distinguish|17α-Dihydroequilin|17β-Dihydroequilin|17α-Dihydroequilenin}}<br />
{{Drugbox<br />
| Verifiedfields = <br />
| Watchedfields = <br />
| verifiedrevid = <br />
| IUPAC_name = (13''S'',14''S'',17''S'')-13-methyl-11,12,14,15,16,17-hexahydrocyclopenta[''a'']phenanthrene-3,17-diol<br />
| image = 17β-Dihydroequilenin.svg<br />
| width = 225px<br />
<br />
<!--Clinical data--><br />
| tradename = <br />
| pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --><br />
| pregnancy_US = <!-- A / B / C / D / X --><br />
| pregnancy_category = <br />
| legal_AU = <!-- Unscheduled / S2 / S3 / S4 / S5 / S6 / S7 / S8 / S9 --><br />
| legal_CA = <br />
| legal_UK = <br />
| legal_US = <br />
| legal_status = <br />
| routes_of_administration = [[Oral administration|By mouth]]<br />
| class = [[Estrogen (medication)|Estrogen]]<br />
<br />
<!--Pharmacokinetic data--><br />
| bioavailability = <br />
| protein_bound = <br />
| metabolism = <br />
| elimination_half-life = <br />
| excretion = <br />
<br />
<!-- Identifiers --><br />
| CAS_number_Ref = {{cascite|correct|CAS}}<br />
| CAS_number = 1423-97-8<br />
| UNII_Ref = {{fdacite|correct|FDA}}<br />
| UNII = ET2MK3VGB4<br />
| CAS_supplemental = <br />
| ATC_prefix = <br />
| ATC_suffix = <br />
| ATC_supplemental = <br />
| PubChem = 3032407<br />
| IUPHAR_ligand = <br />
| DrugBank_Ref = <br />
| DrugBank = <br />
| ChemSpiderID_Ref = <br />
| ChemSpiderID = 2297390 <br />
| KEGG = <br />
| ChEBI = <br />
| ChEMBL = 123405<br />
| synonyms = β-Dihydroequilenin; Δ<sup>6,8</sup>-17β-Estradiol; 6,8-Didehydro-17β-estradiol; Estra-1,3,5(10),6,8-pentaen-3,17β-diol<br />
<br />
<!--Chemical data--><br />
| C=18 | H=20 | O=2<br />
| SMILES = C[C@]12CCC3=C([C@@H]1CC[C@@H]2O)C=CC4=C3C=CC(=C4)O<br />
| StdInChI_Ref = <br />
| StdInChI = 1S/C18H20O2/c1-18-9-8-14-13-5-3-12(19)10-11(13)2-4-15(14)16(18)6-7-17(18)20/h2-5,10,16-17,19-20H,6-9H2,1H3/t16-,17-,18-/m0/s1<br />
| StdInChIKey_Ref = <br />
| StdInChIKey = RYWZPRVUQHMJFF-BZSNNMDCSA-N<br />
}}<br />
<br />
'''17β-Dihydroequilenin''', or '''β-dihydroequilenin''', also known as '''δ<sup>6,8</sup>-17β-estradiol''' or '''6,8-didehydro-17β-estradiol''', as well as '''estra-1,3,5(10),6,8-pentaen-3,17β-diol''', is a [[naturally occurring]] [[steroid]]al [[estrogen (medication)|estrogen]] found in [[equine|horse]]s which is closely related to [[equilin]], [[equilenin]], and [[estradiol (medication)|estradiol]], and, as the 3-[[sulfate]] [[ester]] [[sodium]] [[salt (chemistry)|salt]], is a minor constituent (0.5%) of [[conjugated estrogens]] (Premarin).<ref name="FritzSperoff2012">{{cite book| vauthors = Fritz MA, Speroff L | chapter = Postmenopausal Hormone Therapy |title=Clinical Gynecologic Endocrinology and Infertility |chapter-url=https://books.google.com/books?id=KZLubBxJEwEC&pg=PA751|date=28 March 2012|publisher=Lippincott Williams & Wilkins|isbn=978-1-4511-4847-3|pages=751–}}</ref> 17β-Dihydroequilenin has unexpectedly shown a [[selective estrogen receptor modulator]] (SERM)-like profile of estrogenic activity in studies with monkeys, in which beneficial effects on [[bone]] and the [[cardiovascular]] system were noted but [[cell proliferation|proliferative]] responses in [[breast]] and [[endometrium]] were not observed.<ref name="pmid17443713">{{cite journal | vauthors = Cline JM | title = Assessing the mammary gland of nonhuman primates: effects of endogenous hormones and exogenous hormonal agents and growth factors | journal = Birth Defects Research. Part B, Developmental and Reproductive Toxicology | volume = 80 | issue = 2 | pages = 126–146 | date = April 2007 | pmid = 17443713 | doi = 10.1002/bdrb.20112 }}</ref><br />
<br />
== See also ==<br />
* {{slink|List of estrogens|Equine estrogens}}<br />
<br />
== References ==<br />
{{Reflist}}<br />
<br />
{{Estrogens and antiestrogens}}<br />
{{Estrogen receptor modulators}}<br />
<br />
{{DEFAULTSORT:Dihydroequilenin, 17β-}}<br />
<br />
[[Category:Secondary alcohols]]<br />
[[Category:Estranes]]<br />
[[Category:Estrogens]]<br />
<br />
<br />
{{Steroid-stub}}<br />
{{Genito-urinary-drug-stub}}</div>
bsd>Fswitzer4