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2-Methoxyestrone - 版の履歴
2026-04-12T15:03:32Z
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WikiSysop: 1版 をインポートしました
2025-03-18T10:27:03Z
<p>1版 をインポートしました</p>
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bsd>JWBE: removed Category:Phenols; added Category:Hydroxyarenes using HotCat
2024-10-21T16:26:16Z
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<p><b>新規ページ</b></p><div>{{Chembox<br />
<!-- Images --><br />
| ImageFile = 2-Methoxyestrone.svg<br />
| ImageSize = 200px<br />
| ImageAlt = <br />
<!-- Names --><br />
| IUPACName = 3-Hydroxy-2-methoxyestra-1,3,5(10)-trien-17-one<br />
| SystematicName = (3a''S'',3b''R'',9b''S'',11a''S'')-7-Hydroxy-8-methoxy-11a-methyl-2,3,3a,3b,4,5,9b,10,11,11a-decahydro-1''H''-cyclopenta[''a'']phenanthren-1-one<br />
| OtherNames = 2-ME1; 2-MeOE1; 2-MeO-E1; 2-Hydroxyestrone 2-methyl ether; 2-Methoxyestra-1,3,5(10)-trien-3-ol-17-one<br />
<!-- Sections --><br />
| Section1 = {{Chembox Identifiers<br />
| CASNo = 362-08-3<br />
| ChEBI = 1189<br />
| ChEMBL = 425194<br />
| ChemSpiderID = 389515<br />
| KEGG = C05299<br />
| PubChem = 440624<br />
| StdInChI = 1S/C19H24O3/c1-19-8-7-12-13(15(19)5-6-18(19)21)4-3-11-9-16(20)17(22-2)10-14(11)12/h9-10,12-13,15,20H,3-8H2,1-2H3/t12-,13+,15-,19-/m0/s1<br />
| StdInChIKey = WHEUWNKSCXYKBU-QPWUGHHJSA-N<br />
| SMILES = C[C@]12CC[C@H]3[C@H]([C@@H]1CCC2=O)CCC4=CC(=C(C=C34)OC)O<br />
| UNII = SJ5857RRL3<br />
}}<br />
| Section2 = {{Chembox Properties<br />
| C=19 | H=24 | O=3<br />
| MolarMass = <br />
| Appearance = <br />
| Density = <br />
| MeltingPt = <br />
| BoilingPt = <br />
| Solubility = <br />
}}<br />
| Section3 = {{Chembox Hazards<br />
| MainHazards =<br />
| FlashPt =<br />
| AutoignitionPt =<br />
}}<br />
}}<br />
<br />
'''2-Methoxyestrone''' ('''2-ME1''') is an [[endogenous]], [[natural product|naturally occurring]] [[methoxyl]]ated [[catechol estrogen]] and [[metabolite]] of [[estrone]] that is formed by [[catechol O-methyltransferase]] via the [[chemical intermediate|intermediate]] [[2-hydroxyestrone]].<ref name="HMDB">{{cite web | url=http://www.hmdb.ca/metabolites/hmdb00010 | title=Human Metabolome Database: Showing metabocard for 2-Methoxyestrone (HMDB0000010) }}</ref><ref name="Hemnes2015">{{cite book | first = Anna R. | last = Hemnes | name-list-style = vanc |title=Gender, Sex Hormones and Respiratory Disease: A Comprehensive Guide|url=https://books.google.com/books?id=4So3CwAAQBAJ&pg=PA32|date=16 December 2015|publisher=Humana Press|isbn=978-3-319-23998-9|pages=32–}}</ref><ref name="LauritzenStudd2005">{{cite book | first1 = Christian | last1 = Lauritzen | first2 = John W. W. | last2 = Studd | name-list-style = vanc |title=Current Management of the Menopause|url=https://books.google.com/books?id=WD7S7677xUUC&pg=PA378|date=22 June 2005|publisher=CRC Press|isbn=978-0-203-48612-2|pages=378–379}}</ref> Unlike estrone but similarly to 2-hydroxyestrone and [[2-methoxyestradiol]], 2-methoxyestrone has very low [[affinity (pharmacology)|affinity]] for the [[estrogen receptor]] and lacks significant estrogenic activity.<ref name="pmid10865186">{{cite journal | vauthors = Bhavnani BR, Nisker JA, Martin J, Aletebi F, Watson L, Milne JK | title = Comparison of pharmacokinetics of a conjugated equine estrogen preparation (premarin) and a synthetic mixture of estrogens (C.E.S.) in postmenopausal women | journal = Journal of the Society for Gynecologic Investigation | volume = 7 | issue = 3 | pages = 175–83 | year = 2000 | pmid = 10865186 | doi = 10.1016/s1071-5576(00)00049-6 }}</ref><br />
<br />
{{Selected biological properties of endogenous estrogens in rats}}<br />
<br />
==See also==<br />
* [[2-Methoxyestradiol]]<br />
* [[2-Methoxyestriol]]<br />
* [[4-Methoxyestradiol]]<br />
* [[4-Methoxyestrone]]<br />
<br />
==References==<br />
{{Reflist}}<br />
<br />
==External links==<br />
* [http://www.hmdb.ca/metabolites/hmdb00010 Metabocard for 2-Methoxyestrone - Human Metabolome Database]<br />
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{{Endogenous steroids}}<br />
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{{DEFAULTSORT:Methoxyestrone, 2-}}<br />
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[[Category:Estranes]]<br />
[[Category:Ethers]]<br />
[[Category:Human metabolites]]<br />
[[Category:Ketones]]<br />
[[Category:Hydroxyarenes]]<br />
<br />
<br />
{{Steroid-stub}}</div>
bsd>JWBE